Search results for "Forced"
showing 10 items of 500 documents
Contexto editorial, cultural y socio-político de la edición príncipe de la «Historia de la doncella Teodor» (Toledo: Pedro Hagenbach, 1500-1501)
2021
The material analysis of the only surviving copy of the editio princeps of the Historia de la doncella Teodor allows us to date it back to the incunabula era and to attribute its printing to Pedro Hagenbach’s workshop. The close relationship amongst Hagenbach’s workshop, the reformist project of Archbishop Cisneros, and the interests of the Catholic Monarchs sets an editorial and cultural context that supports the adaptation of Teodor to the printing press. This work perfectly agreed with the thematic and ideological guidelines for the renewal of Christian customs and values. The forceful religious and intellectual imposition of the young and learned slave, turned into a “fijadalgo” in the …
Flexural behavior of external beam-column reinforced concrete assemblages externally strengthened with steel cages
2016
In this paper, an experimental study referring to the flexural behavior of full-scale external beam-column joints externally strengthened with steel angles and strips and subjected to cyclic reversal loading is presented. One control specimen and five other specimens having the same characteristics as the control specimen but strengthened with steel angles and strips along beams and columns, and characterized by different configurations of strengthening in the critical regions, were tested. The control specimen was designed with a weak column and strong beam to reproduce the most common cases of old frame structures in the Mediterranean area, which were designed only for gravity loads and a…
Influence of column shear failure on pushover based assessment of masonry infilled reinforced concrete framed structures: A case study
2017
Structural frames, constructed either of steel or reinforced concrete (RC), are often infilled with masonry panels. However, during the analysis of the structural frames, it has become common practice to disregard the existence of infills because of the complexity in modeling. This omission should not be allowed because the two contributions (of infills and of frames) complement each other in providing a so different structural system. The use of different modeling assumptions significantly affects the capacity as well as the inelastic demand and safety assessment. In specific, the adoption of equivalent diagonal pin-jointed struts leaves open the problem of the evaluation of the additional…
Analysis of a Collapsed Long-Span Reinforced Concrete Roof in South Italy: Design Mistakes and Material Degradation
2020
In 2004, during ordinary maintenance work, consisting of waterproofing a building located in the south of Italy, the long-span (14.5 m) in situ RC roof partially collapsed. The building, constructed in 1950, was in service as a cinema until 1967 and then utilized as a school until 1985. Lastly, it was a hotel until 2000. In 2004, when the building was not in service and was undergoing maintenance work, it partially collapsed under dead load. After the collapse, which involved a large portion of the roof, several beams, and two columns, the Italian court nominated an official technical consultant to investigate the direct and related causes of the failure. After the main causes were identifi…
Telomere Length in Circulating Leukocytes is Associated with Lung Function and Disease
2014
Several clinical studies suggest the involvement of premature ageing processes in chronic obstructive pulmonary disease (COPD). Using an epidemiological approach, we studied whether accelerated ageing indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the interindividual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15 846 controls defined according to the Global Lungs Initiative (GLI) criteria (or 1189 COPD cases according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria), 2834 asthma cases with 28 195 controls, and s…
Prognostic value of FEV1/FEV6 in elderly people
2010
BACKGROUND: The ratio of forced expiratory volume in 1 s and forced expiratory volume in 6 s (FEV1/FEV6) has been proposed as an alternative for FEV1/forced vital capacity (FVC) to diagnose obstructive diseases with less effort during spirometry; however, its prognostic value is unknown. We evaluated whether FEV1/FEV6 is a significant predictor of mortality in elderly subjects and compared its prognostic value with that of FEV1/FVC and FEV1. METHODS: One thousand nine hundred and seventy-one subjects, aged >65 years, participated in the population-based SA.R.A. study. During the baseline exam, a multidimensional assessment included spirometry. Vital status was determined during 6 years of f…
Prediction Equations for Out-of-Plane Capacity of Unreinforced Masonry Infill Walls Based on a Macroelement Model Parametric Analysis
2021
In the seismic performance assessment of reinforced concrete (RC) frames, a reliable estimation of the capacity of unreinforced masonry (URM) infill walls is of utmost importance to ensure structural safety conditions. With particular attention to the out- of-plane (OoP) capacity of URM infill walls after in-plane (IP) damage, the issue of defining reliable analytical prediction models for the assessment of the capacity is an ongoing study. In this paper, empirical equations are proposed for the evaluation of the infilled frame’s OoP capacity, with or without IP damage, based on an extensive numerical parametric analysis, focusing on the influence of the key parameters that govern the mecha…
Aging and disability affect misdiagnosis of COPD in elderly asthmatics: the SARA study
2003
STUDY OBJECTIVES: This study investigated to what extent a diagnosis of COPD is erroneously made or the disease remains unrecognized in elderly asthmatic patients, and identified factors leading to misdiagnosis and underdiagnosis of asthma in such patients. DESIGN: A multicenter study involving 24 Italian pulmonary or geriatric institutions. PATIENTS: One hundred twenty-eight asthmatic patients (98 women, 76.6%) aged 73 +/- 6.4 years (mean +/- SD) were selected from the cohort of the Salute Respiratoria nell'Anziano (respiratory health in the elderly) study. METHODS: All patients underwent a clinical evaluation that included clinical history and spirometry with a bronchodilator test. A diag…
Circadian rhythm of COPD symptoms in clinically based phenotypes. Results from the STORICO Italian observational study
2019
Abstract Background Chronic Obstructive Pulmonary Disease (COPD) encompasses various phenotypes that severely limit the applicability of precision respiratory medicine. The present investigation is aimed to assess the circadian rhythm of symptoms in pre-defined clinical COPD phenotypes and its association with health-related quality of life (HR-QoL), the quality of sleep and the level of depression/anxiety in each clinical phenotype. Methods The STORICO (NCT03105999) Italian observational prospective cohort study enrolled COPD subjects. A clinical diagnosis of either chronic bronchitis (CB), emphysema (EM) or mixed COPD-asthma (MCA) phenotype was made by clinicians at enrollment. Baseline e…
Effects of long-acting bronchodilators in COPD patients according to COPD severity and ICS use
2013
SummaryBackgroundIndacaterol is a once-daily, long-acting β2-agonist bronchodilator that improves dyspnoea and health status in patients with moderate-to-severe COPD. While its bronchodilator effects have been shown to be maintained in different patient subgroups, effects on clinical outcomes in certain subgroups are not yet defined.MethodsPost-hoc analysis of pooled clinical study data to investigate efficacy and safety of indacaterol compared with placebo and other long-acting bronchodilators (formoterol, salmeterol, open-label tiotropium) in patient subgroups defined by COPD severity (GOLD stage II or III; n = 4082) and ICS use at baseline (no/yes; n = 4088). Efficacy outcomes were troug…