Search results for "Forecast"
showing 10 items of 417 documents
In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration
2019
The availability of in vitro tools that are constructed on the basis of a detailed knowledge of key aspects of gastrointestinal (GI) physiology and their impact on formulation performance and subsequent drug release behaviour is fundamental to the success and efficiency of oral drug product development. Over the last six years, the development and optimization of improved, biorelevant in vitro tools has been a cornerstone of the IMI OrBiTo (Oral Biopharmaceutics Tools) project. By bringing together key industry and academic partners, and by linking tool development and optimization to human studies to understand behaviour at the formulation/GI tract interface, the collaboration has enabled …
Automated anaesthesia record systems, observations on future trends of development.
1995
The introduction of electronic anaesthesia documentation systems was attempted as early as in 1979, although their efficient application has become reality only in the past few years. Today, documentation technology is offered by most of the monitor manufacturers and new systems are being developed by various working groups. The advantages of the electronic protocol are apparent: Continuous high quality documentation, comparability of data due to the availability of a anaesthesia data bank, reduction of the workload of the anaesthesia staff and availability of new additional information. Disadvantages of the electronic protocol have also been discussed. Typically, by going through the proce…
Current and future pharmacologic therapy of exacerbations in chronic obstructive pulmonary disease and asthma.
2005
Exacerbations are an important cause of the morbidity and mortality associated with asthma and chronic obstructive pulmonary disease. Newer therapies include long-acting beta(2)-agonists, which are more effective than short-acting bronchodilators. Inhaled corticosteroids and, in asthma, leukotriene receptor antagonists may have roles in the early phase of exacerbation as an alternative to or added to oral prednisolone. In the future, combinations of long-acting beta(2)-agonists and anticholinergic bronchodilators may offer additive clinical benefits. However, although the treatment and prevention of exacerbations of chronic obstructive pulmonary disease and asthma have been improved by usin…
The future of aortic surgery in Europe
2017
At least every ten years, each specialty should reflect upon its past, its present and its future, in order to be able to reconfirm the direction in which it is headed, to adopt suggestions from inside and outside and, consequently, to improve. As such, the aim of this manuscript is to provide the interested reader with an overview of how aortic surgery and (perhaps more accurately) aortic medicine has evolved in Europe, and its present standing; also to provide a glimpse into the future, trying to disseminate the thoughts of a group of people actively involved in the development of aortic medicine in Europe, namely the Vascular Domain of the European Association of Cardio-Thoracic Surgery …
AGuIX® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine.
2019
International audience; AGuIX® are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been obser…
Automatic Generation of Land Surface Emissivity Maps
2011
The remote sensing measurement of the land surface temperature (LST) from satellites provides an overview of this magnitude on a continuous and regular basis. The study of its evolution in time and space is a critical factor in many scientific fields such as weather forecasting, detection of forest fires, climate change, etc. The main problem of making this measurement from satellite data is the need to correct the effects of the atmosphere and the land surface emissivity (LSE). Nowadays, these corrections are usually made using a split-window algorithm, which has an explicit dependence on land surface emissivity. Therefore, the aim of our work was to define an enhanced vegetation cover met…
The green roofs for reduction in the load on rainwater drainage in highly urbanised areas
2021
AbstractRapid weather phenomena, particularly sudden and intense rainfall, have become a problem in urban areas in recent years. During heavy rainfall, urban rainwater drainage systems are unable to discharge huge amounts of runoff into collecting reservoirs, which usually results in local flooding. This paper presents attempts to forecast a reduction in the load on the rainwater drainage system through the implementation of green roofs in a case study covering two selected districts of Opole (Poland)—the Old Town and the City Centre. Model tests of extensive and intensive roofs were carried out, in order to determine the reduction of rainwater runoff from the roof surface for the site unde…
Forecasts on the development of hydrogen refuelling infrastructures in Portugal
2021
In Portugal, the transition to new forms of mobility has begun in recent years, but there are still obstacles to overcome. Currently, hybrid vehicles (PHEVs) are the most widespread and accepted by the community and that is probably due to range anxiety, having in fact the possibility of double charging (both through the thermal engine and the electric battery). Furthermore, it must be considered that in addition to electric vehicles, another valid alternative to mobility in the near future is the hydrogen vehicles one. These appear to be even more sustainable from the point of view of air emissions, but on the other hand the costs for the production of hydrogen are still too high. Then, th…
Comparing Recurrent Neural Networks using Principal Component Analysis for Electrical Load Predictions
2021
Electrical demand forecasting is essential for power generation capacity planning and integrating environment-friendly energy sources. In addition, load predictions will help in developing demand-side management in coordination with renewable power generation. Meteorological conditions influence urban area load pattern; therefore, it is vital to include weather parameters for load predictions. Machine Learning algorithms can effectively be used for electrical load predictions considering impact of external parameters. This paper explores and compares the basic Recurrent Neural Networks (RNN); Simple Recurrent Neural Networks (Vanilla RNN), Gated Recurrent Units (GRU), and Long Short-Term Me…
Relative evaluation of regression tools for urban area electrical energy demand forecasting
2019
Abstract Load forecasting is the most fundamental application in Smart-Grid, which provides essential input to Demand Response, Topology Optimization and Abnormally Detection, facilitating the integration of intermittent clean energy sources. In this work, several regression tools are analyzed using larger datasets for urban area electrical load forecasting. The regression tools which are used are Random Forest Regressor, k-Nearest Neighbour Regressor and Linear Regressor. This work explores the use of regression tool for regional electric load forecasting by correlating lower distinctive categorical level (season, day of the week) and weather parameters. The regression analysis has been do…