Search results for "Forecasting"

Genomics and the gene transcription kinetics in yeast.

2007

As an adaptive response to new conditions, mRNA concentrations in eukaryotes are readjusted after any environmental change. Although mRNA concentrations can be modified by altering synthesis and/or degradation rates, the rapidity of the transition to a new concentration depends on the regulation of mRNA stability. There are several plausible transcriptional strategies following environmental change, reflecting different degrees of compromise between speed of response and cost of synthesis. The recent development of genomic techniques now enables researchers to determine simultaneously (either directly or indirectly) the transcription rates and mRNA half-lifes, together with mRNA concentrati…

RNAi knock-down mice: an emerging technology for post-genomic functional genetics

2003

RNA interference (RNAi) has been extensively used for sequence-specific silencing of gene function in mammalian cells. The latest major breakthrough in the application of RNAi technology came from experiments demonstrating RNAi-mediated gene repression in mice and rats. After more than two decades of functional mouse research aimed at developing and continuously improving transgenic and knock-out technology, the advent of RNAi knock-down mice represents a valuable new alternative for studying gene function in vivo. In this review we provide some basic insight as to how RNAi can induce gene silencing to then focus on recent findings concerning the applicability of RNAi for regulating gene fu…

Real Options: an Application to RMS Investment Evaluation

2007

Uterus Transplantation

2018

Uterus transplantation (UTx) has been successfully introduced as a treatment option for women with absolute uterine factor infertility (AUFI). AUFI representing approximately 3% to 5% of the female general population is linked to either congenital uterine agenesis (Mayer-Rokitansky-Küster-Hauser syndrome), major congenital uterine malformation (hypoplastic uterus, fraction of bicornuate/unicornuate uterus), a surgically absent uterus, or an acquired condition (intrauterine adhesions, leiomyoma) linked to uterine malfunction that causes implantation failure or defect placentation. The world's first clinical uterus transplant was performed in 2000. However, a hysterectomy became necessary sho…

E-health progresses in Romania

2006

The paper is presenting the recent evolution of e-health aspects in Romania. Data presented are based on governmental reports. Surveys organized by the "Lucian Blaga" University of Sibiu and studies carried on by the national Institute for Research and Development in Informatics (I.C.I.) have shown that Romania has important health problems, from cardio vascular diseases (CVD) to cancer and infectious diseases, a high score on mortality and morbidity and a low one on natality. Poor management of the health sector did not help to solve all these problems. In the last 14 years there were several attempts to reform healthcare but none succeeded until now. The health insurance system is operati…

[The key role of public health medical resident education for future public health challenges].

2015

The Italian Committee of medical residents in Hygiene, Preventive Medicine and Public Health is a member of the Italian Society of Hygiene, Preventive Medicine and Public Health with the aim of developing a network among Italian resident in public health and promoting the educational path improvement through comparisons and debates between postgraduate medical schools. In this perspective, during last years account has been taken of some essential topics concerning education of public health medical residents, which represent future health-care and public health experts.Cross-sectional researches were conducted among Italian public health medical residents (PHMRs) through self-administered …

Do different models induce changes in mortality indicators? That is a key question for extending the Lee-Carter model

2021

[EN] The parametric model introduced by Lee and Carter in 1992 for modeling mortality rates in the USA was a seminal development in forecasting life expectancies and has been widely used since then. Different extensions of this model, using different hypotheses about the data, constraints on the parameters, and appropriate methods have led to improvements in the model's fit to historical data and the model's forecasting of the future. This paper's main objective is to evaluate if differences between models are reflected in different mortality indicators' forecasts. To this end, nine sets of indicator predictions were generated by crossing three models and three block-bootstrap samples with …

Evaluation of activated sludge model no.2 at high phosphorus concentrations

2001

This paper presents laboratory scale experimentation carried out to study enhanced biological phosphorus removal at high phosphorus concentrations in a sequencing batch reactor. Four series of data obtained in a sequencing batch reactor are examined in light of the Activated Sludge Model No. 2. This model was calibrated using data from the first and second series working at low phosphorus concentrations. The Activated Sludge Model No. 2 successfully characterised the enhanced biological phosphorus removal performance of the sequencing batch reactor at low phosphorus concentrations. The calibrated model was then used to adjust experimental results of the other series working at high phosphor…

Effects of initialization on response of a fully-distributed hydrologic model

2008

Summary Knowledge of initial conditions is very important to correctly model the basin response at the storm event scale. Of particular interest is the influence of topography and soil type on the principal hydrologic variables and runoff generation mechanisms as a function of antecedent wetness conditions. This study addresses the influence of initial states on the short-term hydrologic response and characterizes the effects of topography and soils on the dissipation of the influence of the initialization conditions. Two case studies are considered: a synthetic two-dimensional planar hillslope with various assumed slope magnitudes and soil types; and a real basin (∼800 km2) with actual lan…

Dominating Clasp of the Financial Sector Revealed by Partial Correlation Analysis of the Stock Market

2010

What are the dominant stocks which drive the correlations present among stocks traded in a stock market? Can a correlation analysis provide an answer to this question? In the past, correlation based networks have been proposed as a tool to uncover the underlying backbone of the market. Correlation based networks represent the stocks and their relationships, which are then investigated using different network theory methodologies. Here we introduce a new concept to tackle the above question--the partial correlation network. Partial correlation is a measure of how the correlation between two variables, e.g., stock returns, is affected by a third variable. By using it we define a proxy of stoc…