Search results for "Forensic"

Bortezomib Partially Improves Laminin α2 Chain–Deficient Muscular Dystrophy

2014

Congenital muscular dystrophy, caused by mutations in LAMA2 (the gene encoding laminin α2 chain), is a severe and incapacitating disease for which no therapy is yet available. We have recently demonstrated that proteasome activity is increased in laminin α2 chain-deficient muscle and that treatment with the nonpharmaceutical proteasome inhibitor MG-132 reduces muscle pathology in laminin α2 chain-deficient dy(3K)/dy(3K) mice. Here, we explore the use of the selective and therapeutic proteasome inhibitor bortezomib (currently used for treatment of relapsed multiple myeloma and mantle cell lymphoma) in dy(3K)/dy(3K) mice and in congenital muscular dystrophy type 1A muscle cells. Outcome measu…

�ber das Zwischenhirn-Hypophysensystem vonProtopterus annectens

1957

1. Das neurosekretorische Zwischenhirn-Hypophysensystem vonProtopterus annectens zeigt in bezug auf Ausdehnung und Anordnung seiner Anteile sehr starke Ahnlichkeit mit dem der anuren Amphibien. 2. Der Nucleus praeopticus liegt zu beiden Seiten des 3. Ventrikels. Er erstreckt sich dorsal bis unter das Ependym und ventral bis zum Chiasma opticum. Seine Ganglienzellen sind gros mit rundem glattrandigem Kern. Sie enthalten wenig peripher gelegene Kugeln und Granula von Neurosekret, das offenbar auf Kosten der Nissl-Substanz gebildet wird. 3. Der Tractus praeoptico-hypophyseus beginnt wie bei den Anuren mit 2 Teilen, einem rostro-ventral im Bogen verlaufenden und einem direkt schrag von dorsal n…

�ber den Feinbau der Paraphyse vonProtopterus annectens

1957

1. Die Paraphyse vonProtopterus annectens ist eine Aussackung des hautigen Zwischenhirndaches, in die hinein sich der 3. Ventrikel fortsetzt. 2. Ihre Wandung besteht aus einem einschichtigen Epithel, das besonders im medialen und rostralen Bereich des Organs stark gefaltet ist. Die Falten engen das Ventrikellumen ein. An der Basis des Epithels liegen Kapillaren. 3. Die kubischen Epithelzellen tragen an ihrer Oberflache einen Burstensaum. Sie enthalten Vakuolen und stark farbbare Tropfen; an der freien Zelloberflache liegen abgeschnurte Ballen von Sekret. Diese Erscheinungen werden als Zeichen fur eine lebhafte sekretorische Tatigkeit des Paraphysenepithels angesehen. 4. Zwischen dem Paraphy…

Criminal thinking: exploring its relationship whith prosocial behavior, emotional intelligence, and cultural dimensions

2023

This study explores the relationship between criminal thinking and other variables related to criminal cognition. Prosocial behavior, emotional intelligence, and cultural dimensions were chosen to check their predictive capacity for criminal thinking. The research sample comprised 695 young university students and adults, chosen by a non-probabilistic sampling method. The instruments used were the Criminal Sentiments Scales (CSS-M), the Prosociality Scale, the Emotional Intelligence Scale (EQI-C), and the Scale of Cultural Dimensions in its Spanish adaptation. A MANOVA, correlations, and lineal regressions were conducted using SPSS 26 and a SEM was proposed with the results obtained. Crimin…

The institutionalisation of young offenders

1993

Types of Offense among the Cleckley Psychopaths

1994

The Cleckley psychopath is superficially charming and convincing in his behavior but also unreliable and callous. These personality characteristics imply that he/she may be prone to deceive and manipulate others. In the area of criminality, this may mean apropensity to fraud-like offenses. The present paper tested the argument by comparing types of offense committed by psychopaths and nonpsychopaths. The Psychopathy Checklist was used for psychopathy assessments. In a sample of 92 male offenders, the percentage of the Cleckley psychopaths convicted for fraud-like offenses was higher than among the other offenders. The results were discussed with respect to the problem of circular conclusio…

Cognitive Insight, Clinical Insight, and Reasoning in Schizophrenia : A Pilot Study in a Forensic Setting

2016

This pilot study of 20 chronically ill male inpatients with schizophrenia and a history of violence investigates the relationships between cognitive insight, clinical insight, reasoning, and symptoms in a forensic setting. The majority (75%) of the patients with schizophrenia made hasty decisions based on a small amount of information (the jumping-to-conclusion bias, JTC). In addition, the data suggested that the more information patients gather, the more clinical insight they have and the less distressed they are by their symptoms. However, neither cognitive nor clinical insight were found to be statistically significantly associated with symptoms. The Beck Cognitive Insight Scale (BCIS) s…

Minimum cause--maximum effect: the travelogue of a bullet.

2010

This case report involves a 57-year-old male, accidentally shot in the chest with a small bore firearm. The bullet entered the left hemithorax, disrupting the left internal mammarian artery. It then penetrated the anterior wall of the right ventricle causing a pericardial tamponade. After leaving the base of the right heart it perforated the diaphragm, the liver, the spleen and the pancreas. Finally, it penetrated the abdominal aorta 3 cm proximally to the coeliac trunk and reached its final position paravertebrally. This case report illustrates that the management of even minimum gunshot wounds requires a maximum variety of surgical skills. Keywords: Thoracoabdominal injury; Shotgun wound;…

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach.

2005

Lung is a target organ for the toxicity of inhalated compounds. The respiratory tract is frequently exposed to elevated concentrations of these compounds and become the primary target site for toxicity. Occupational, accidental or prolonged exposure to a great variety of chemicals may result in acute or delayed injury to cells of the respiratory tract. Nevertheless, lung has a significant capability of biotransforming such compounds with the aim of reducing its potential toxicity. In some instances, the biotransformation of a given compound can result in the generation of more reactive, and frequently more toxic, metabolites. Indeed, lung tissue is known to activate pro-carcinogens (i.e. po…

Authoritarian exclusion and laissez‐faire inclusion: Comparing the punishment of men convicted of sex offenses in England & Wales and Norway*

2021

Abstract: Comparative penologists have described neoliberal and social democratic jurisdictions as though they exist at opposite ends of a continuum of inclusion and exclusion, and as though neoliberal states are inactive and social democratic states are invasive. This article, which is based on more than 129 interviews with men convicted of sex offenses in England & Wales and Norway, uses Cohen's work on inclusion and McNeill's typology of rehabilitative forms to complicate this simplistic binary. It argues that the punishment of men convicted of sex offenses in England & Wales was demanding but exclusionary; it imposed strict legal restrictions on these men during and after their imprison…