Search results for "Forensic"
showing 10 items of 1701 documents
Cell of origin markers identify different prognostic subgroups of lung adenocarcinoma
2018
Strong prognostic markers able to stratify lung adenocarcinoma (ADC) patients are lacking. We evaluated whether a six-immunohistochemical markers panel (TTF1, SP-A, Napsin A, MUC5AC, CDX2 and CK5), defining the putative neoplastic “cell of origin,” allows to identify prognostic subgroups among lung ADC. We screened a large cohort of ADC specimens (2003–2013) from Torino Institutional Repository identifying: (i) marker positivity by immunohistochemistry, (ii) main morphological appearance by light microscopy, (iii) presence of “hotspot” mutations of candidate genes by Sequenom technology. To evaluate possible predictors of survival and time to recurrence, uni- and multivariable-adjusted comp…
Standardisierte pathoanatomische Befunddokumentation auf den ADT-Tumorb�gen f�r Malignome des Mundes, der Kiefer und des Gesichts (Version III)
1995
The documentation form for pathohistologic findings (version III) for tumors of the maxillofacial region is presented. It is part of the site-specific documentation of the German Association of Tumor Centers (ADT). Its handling is explained by instructions which are based on the ICD-O classification and the TNM system. The prognostic relevance of the standardized documentation has already been proven by various histomorphologic investigations concerning oral and oropharyngeal cancer. By means of a multicentric observational study the German Austrian Swiss co-operative group DOSAK will develop a new prognostic model for oral and oropharyngeal cancer.
The activation of ERK1/2 MAP kinases in glioblastoma pathobiology and its relationship with EGFR amplification.
2008
The ERK1/2 activated protein kinase (MAPK) pathway is a critical signaling system that mediates ligand-stimulated signals for the induction of cell proliferation, differentiation and survival, involved in malignant transformation. The purpose of this study was to determine the activation of ERK1/2 in this tumor, and to determine the relationship of ERK1/2 activation with the amplification/overexpression of EGFR as well as with 9p21 locus gene alterations, both of which are genetic factors frequently associated with glioblastoma. We used immunohistochemistry and Western blot analysis to analyze the activation of ERK1/2 in 22 patients with glioblastoma, and we studied the amplification/overex…
Evolution of osmosensing signal transduction in Metazoa: stress-activated protein kinases p38 and JNK.
2001
Sponges (Porifera) represent the most basal branch of the Metazoa alive today. We show that two central stress-activated protein kinases involved in the osmosensing pathway, p38 mitogen-activated protein kinase (MAPK) and JNK, can complement for the ancestral MAPK Hog1 in the yeast Saccharomyces cerevisiae. S. cerevisiae mutants lacking Hog1 (hog1-Delta 1) have been complemented with the sponge SDJNK and SDp38 genes. Western blotting has revealed that, after transformation, the hog1-Delta 1+ SDJNK(sense) and hog1-Delta 1+ SDp38(sense) clones express the sponge proteins. Functional studies have demonstrated that the complemented clones grow under hyperosmotic conditions (0.6 M NaCl). Further…
Betydningen av fysisk aktivitet i forhold til psykisk helse
2010
Masteroppgave i psykisk helsearbeid- Universitetet i Agder 2010 The purpose of this study is to gain knowledge, insight and a deeper understanding of how physical activity is apprehended. Also what kind of influence has in the prevention and treatment of mental health. The study aims to understand the participant’s subjective experience through their perspective. This master thesis is a qualitative study based on a phenomenological and hermeneutical tradition. The empirical material is based on the qualitative research interview. Five interviews have been conducted. The interview subjects have experience with physical activity in relation to mental health, both through work and personal exp…
Hva er egnethet? : en kvalitativ studie av gode møter i en akuttpsykiatrisk sykehuspost
2010
Masteroppgave i psykisk helsearbeid- Universitetet i Agder 2010 Title/subtitle: What is suitability? A quality study of good meetings in an acute psychiatric hospital ward. Purpose: The purpose of this study is to increase the knowledge about and to clarify the concept suitability in an acute psychiatric hospital ward. How are the gifted member of staff, and how do patients and employees wish to be met? The focus is the patients and employees descriptions of good meetings. The good examples are to be put in the front. By clarifying the important factors in the field, the knowledge of the good meetings will appear. Theoretical basis: This study is founded on a phenomenological-hermeneutic fr…
Alle kan bli syke" : en beskrivelse av hvordan språket bidrar til meningsdannelse for ansatte og brukere på et kommunalt treffsted for mennesker med …
2010
Masteroppgave i psykisk helsearbeid- Universitetet i Agder 2010 TITLE: "Anyone can get sick" - A description of how language contributes to the opinion of the employees and users at a local meeting place for people with mental disorders. In this study, my focus has been on the importance of language in mental health care, by examining how language can contribute to the opinion. I have been concerned with the task of looking at the truths involved, when we do not always say what we think about mental poor health, and expressed as self-evident truths. My understanding of language and people say something about what might be involved in maintaining self-evident truths that "all may be sick." I…
Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture
2021
AbstractSaccular intracranial aneurysm (sIA) rupture leads to a disabling subarachnoid hemorrhage. Chronic inflammation and lipid accumulation in the sIA wall contribute to wall degenerative remodeling that precedes its rupture. A better understanding of the pathobiological process is essential for improved future treatment of patients carrying sIAs. Serum amyloid A (SAA) is an acute-phase protein produced in response to acute and chronic inflammation and tissue damage. Here, we studied the presence and the potential role of SAA in 36 intraoperatively resected sIAs (16 unruptured and 20 ruptured), that had previously been studied by histology and immunohistochemistry. SAA was present in all…
Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 deficiency reduces leukocyte infiltration into adipose tissue and favors fat deposi…
2009
1525-2191 (Electronic) Journal Article; Obesity is associated with low-grade inflammation and leukocyte infiltration in white adipose tissue (WAT) and is linked to diabetic complications. Semicarbazide-sensitive amine oxidase, also known as vascular adhesion protein-1 (SSAO/VAP-1), is a membrane protein that is highly expressed in adipocytes and is also present on the endothelial cell surface where it is involved in leukocyte extravasation. We studied fat deposition and leukocyte infiltration in WAT of mice with a null mutation in the amine oxidase copper-containing-3 (AOC3) gene encoding SSAO/VAP-1. Both epididymal and inguinal WATs were larger in 6-month-old AOC3-KO males than in age-matc…
Unexpected identification and characterization of a cathinone precursor in the new psychoactive substance market: 3',4'-methylenedioxy-2,2-dibromobut…
2019
Abstract 3′,4′-methylenedioxy-2,2-dibromobutyrophenone has been identified and fully characterized in a sample obtained from an anonymous consumer acquired as ketamine through the Internet market. The substance has been deeply characterized by using standard and high performance analytical techniques such as: attenuated total reflectance-infrared spectroscopy, gas chromatography–mass spectrometry, high-resolution mass spectrometry, elemental analysis, and nuclear magnetic resonance, including 1H, 13C, distortionless enhancement by polarization transfer, two dimensional homonuclear 1H-1H correlation spectroscopy, and 1H-13C heteronuclear single-quantum correlation spectra. 3′,4′-methylenedio…