Search results for "Format"
showing 10 items of 24643 documents
Conceptualizing ecosystem tipping points within a physiological framework
2017
Connecting the nonlinear and often counterintuitive physiological effects of multiple environmental drivers to the emergent impacts on ecosystems is a fundamental challenge. Unfortunately, the disconnect between the way “stressors” (e.g., warming) is considered in organismal (physiological) and ecological (community) contexts continues to hamper progress. Environmental drivers typically elicit biphasic physiological responses, where performance declines at levels above and below some optimum. It is also well understood that species exhibit highly variable response surfaces to these changes so that the optimum level of any environmental driver can vary among interacting species. Thus, specie…
Highly-parallelized simulation of a pixelated LArTPC on a GPU
2023
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The alg…
Analysis of the psicometric properties of a multiplication and division processes assessment scale
2019
Esta comunicación se encuentra disponible en la siguiente URL: http://www.infad.eu/RevistaINFAD/OJS/index.php/IJODAEP/article/view/1464/1321 Este número está dedicado a la "Psicología de la Educación y Saberes Originarios". The domain of multiplication and division operations depends on both algorithm management and the ability to identify the semantic structure of the problem and to translate it into mathematical language. Many students present difficulties in identifying the semantic structure of the problem but not applying the algorithm when the problem is presented numericaly. The aim of the study is to validate an assessment tool of the processes involved in multiplication and divisio…
Informasjonsflyt ved mottak og respons på trygghetsalarmer : en casestudie for å undersøke hvilken betydning tilgang på informasjon og informasjonsfl…
2016
Masteroppgave i helse- og sosialinformatikk- Universitetet i Agder, 2016 The theme of this study is security alarms and information flow. The background for the study is estimates regarding an upcoming growing number of security alarms in municipal healthcare services, recommendations on the transition from analogue to digital security alarms, and reports on the current organization of the safety alarms of varying quality and low efficiency (Frantzen, 2014; Fensli, 2015 Kvernland-Berg, 2014). Purpose The aim of this study was to find what importance access to information and information flow had in the working process with security alarms for a future-oriented health services. Method The su…
Matkalla 3D-tulostettuun maailmaan
2018
3D-tulostus ei ole aivan uusi asia, mutta laajempaan tietoisuuteen ala on noussut vasta viime vuosina. Tällä hetkellä 3D-tulostusta hyödynnetään paljon teollisuuden eri aloilla, kuten esimerkiksi lääketieteessä ja teollisessa muotoilussa, mutta tulostimien hintojen laskettua merkittävästi viime vuosina on niiden pienimuotoinen käyttö lisääntynyt myös tavallisen kuluttajan harrastevälineenä. Mutta mitä 3D-tulostus käytännössä tarkoittaa ja millainen on alan tilanne nyt ja tulevaisuudessa? nonPeerReviewed
Hyperplastic callus formation in osteogenesis imperfecta: CT and MRI findings.
1998
Hyperplastic callus formation is a noteworthy condition in patients with osteogenesis imperfecta because it often mimicks osteosarcoma on radiography. The findings of CT and MRI in hyperplastic callus formation have not been reported. In the presented case, MRI demonstrated contrast enhancement and edema of the surrounding soft tisssue, consistent with benign as well as malignant disease. Computed tomography showed a calcified rim of the lesion which may be a useful feature to rule out osteosarcoma in this condition.
Phenotypic spectrum and genomics of undiagnosed arthrogryposis multiplex congenital
2022
BackgroundArthrogryposis multiplex congenita (AMC) is characterised by congenital joint contractures in two or more body areas. AMC exhibits wide phenotypic and genetic heterogeneity. Our goals were to improve the genetic diagnosis rates of AMC, to evaluate the added value of whole exome sequencing (WES) compared with targeted exome sequencing (TES) and to identify new genes in 315 unrelated undiagnosed AMC families.MethodsSeveral genomic approaches were used including genetic mapping of disease loci in multiplex or consanguineous families, TES then WES. Sanger sequencing was performed to identify or validate variants.ResultsWe achieved disease gene identification in 52.7% of AMC index pati…
Treatment of Knee Osteochondral Fractures.
2022
Osteochondral lesions (OCLs) that are frequently encountered in skeletally immature and adult patients are more common than once thought, and their incidence rate is rising. These lesions can appear in many synovial joints of the body, such as the shoulder, elbow, hip, and ankle, occurring most often in the knee. The term osteochondral lesion includes a vast spectrum of pathologies such as osteochondritis dissecans, osteochondral defects, osteochondral fractures, and osteonecrosis of the subchondral bone. When considering this, the term osteochondral fracture is preserved only for an osteochondral defect that combines disruption of the articular cartilage and subchondral bone. These fractur…
Modulation of type II collagen-induced arthritis in DBA/1 mice by intravenous application of a peptide from the C1q-A chain.
1992
In this report we are able to show that intravenous (i.v.) application (day 0) of a nonapeptide (residues 26-34) from the human C1q A-chain (designated peptide A-C1q) prior to intradermal (i.d.) administration of chicken type II collagen (CII) in arthritis-susceptible DBA/1 mice (H2q), leads to abrogation of polymorphonuclear neutrophil (PMN) invasion into the joints. This nonapeptide exhibits epitope characteristics and high homology to residues 137-147 of CB11 (a cyanogen bromide fragment of chicken CII, known to contain both arthritis inducing and suppressing determinants). Arthritis index was lowest in animals pretreated i.v. with CII (as internal control), though animals pretreated i.v…
IAP proteins as targets for drug development in oncology.
2013
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …