Search results for "Forming."

Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway …

2004

Several reports have stated the ability of gamma delta T cells to inhibit the growth of the asexual blood stages of Plasmodium falciparum in vitro. However, little information is available about the mechanisms involved. In this study, in vitro systems were used to study the role of the granule exocytosis-dependent cytotoxic pathway in the growth inhibition/killing of P. falciparum by human gamma delta T cells. Our results show that the inhibition requires cell-to-cell contact and that gamma delta T cells kill the asexual blood stages of P. falciparum through a granule exocytosis-dependent cytotoxic pathway after recognition of certain ligands or molecules expressed on the surface of infecte…

Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice.

2014

Polymorphonuclear neutrophils (PMN) are important for the control of invasive aspergillosis (IA), a major threat to immunocompromised individuals. For clearance of Aspergillus fumigatus infections, PMN employ their potent oxidative and non-oxidative mechanisms. To clarify the relative contribution of these mechanisms, we analyzed p47(phox-/-), gp91(phox-/-) and elastase (ELA) deficient mice (ELANE) after intratracheal infection with A. fumigatus. Infected p47(phox-/-) and gp91(phox-/-) mice died within 4 days and had a significant higher fungal burden in the lungs compared to wild-type controls. Interestingly, the survival of ELANE mice after infection was unimpaired suggesting that ELA is …

Resveratrol modulates the levels of microRNAs targeting genes encoding tumor-suppressors and effectors of TGFbeta signaling pathway in SW480 cells.

2010

International audience; Resveratrol (trans-3,4',5-trihydroxystilbene) is a natural antioxidant with cardiovascular and cancer preventive properties that is currently at the stage of pre-clinical studies for human cancer prevention. Beside its known effects on protein coding genes, one possible mechanism for resveratrol protective activities is by modulating the levels of non-coding RNAs. Here, we analyzed the effects of resveratrol on microRNA populations in human SW480 colon cancer cells. We establish that resveratrol treatment decreases the levels of several oncogenic microRNAs targeting genes encoding Dicer1, a cytoplasmic RNase III producing mature microRNAs from their immediate precurs…

Bax-derived membrane-active peptides act as potent and direct inducers of apoptosis in cancer cells.

2011

SUMMARYAlthough many cancer cells are primed for apoptosis, they usually develop resistance to cell death at multiple levels. Permeabilization of the outer mitochondrial membrane, which is mediated by proapoptotic Bcl-2 family members like Bax, is considered as a point-of-no-return for initiating apoptotic cell death. This crucial role has placed Bcl-2 family proteins as recurrent targets for anticancer drug development. Here, we propose and demonstrate a new concept based on using minimal active version of Bax to induce cell death independently of endogenous Bcl-2 proteins. We show that membrane-active segments of Bax can directly induce the release of mitochondria-residing apoptogenic fac…

Response by C. Aranegui Gascó to E. Papi’s review of Lixus 3 (JRA 26 [2013] 800-7)

2015

Coinage and images of the imperial family: local identity and Roman rule

2013

In his speech “About harmony between the cities”, Publius Aelius Aristides, the famous orator of the mid-2nd c. A.D., admonishes the three most eminent cities of Asia — Pergamum, Ephesus and Smyrna — to put an end to their rivalries. He regards as useless their envy and struggle to be first among the cities in the province of Asia. He cautions against such rivalries, which could lead to an unwanted intervention by Roman authorities. He continues (Or. 23 [Keil = 42 Dindorf] 62): Is there a child or an old man so much out of mind that he would ignore that this is our present situation and that this is thank heaven the ruling law: one city, the first and greatest, has the whole world under one…

L’évolution récente des expositions temporaires sur le Moyen Âge en Italie: Public, thèmes, finalités

2011

This article proposes a reflection about Italian art exhibitions on Middle Ages all over the twentieth century in order to understand the reception of medieval history in Italy. The Italian case is compared with the other European countries and their own relationships with Middle Ages. The articles studies also the important changes in the cultural offer and in the museum function during the last decade of the twentieth century and analyses their major consequences on the exhibitions. Lastly the ‘status’ of the exhibited objects and their mise-en-scene are examined.

The ‘grave of the Court Pit’, A rediscovered Bronze Age tomb from Carchemish

2014

This paper examines the British Museum unpublished records related to an Early Bronze (EB) Age pithos burial uncovered a century ago in the Inner Town at Carchemish. The grave, cursorily cited and variously dated (Chalcolithic, EB or even LBA) in the final reports, was described in some detail by Hogarth and Thompson; a precise dating is, however, possible today thanks to the information of paramount importance given by T. E. Lawrence who identified and took a picture of the associated finds, which was recently rediscovered in the Carchemish Archives. The pithos can be now ascribed to the third quarter of the third millennium BC and helps to confirm the recent theory according to which the …

S. Seelentag, DER PSEUDOVIRGILISCHE CULEX: TEXT-ÜBERSETZUNG-KOMMENTAR (Hermes Einzelschriften 105). Stuttgart: Franz Steiner, 2012. Pp. 260. isbn9783…

2013

Le motif du médecin tyran de Platon à Galien

2014

At various points in Method of medicine and in a passage in the Commentary on the Hippocratic Epidemics Galen takes up the image of the tyrant doctor employed by Plato in the famous passage in the Laws in which, to illustrate the role of the proem to the law, he introduces the contrast between doctors of freemen and doctors of slaves (Leg. IV 719e 8-720e 5) : this is an unexplored chapter of Galen’s Platonism.