Search results for "Forming."
showing 10 items of 1704 documents
Joaquín Sorolla, ideólogo del museo de arte de Alicante. Historia y fortuna crítica de un proyecto para una ciudad
2023
En 1919, el Ayuntamiento de Alicante, en reunión plenaria, admitió una propuesta través de la cual se exponía la idea de Joaquín Sorolla de crear un museo de arte para la ciudad. El proyecto, que fue acogido con gran entusiasmo, atravesó diferentes avatares que dificultaron su inauguración provocando el desánimo en la sociedad. Aun así, el pueblo alicantino no desistió en su empeño hasta pocos meses antes de la Guerra Civil y, gracias a distintas fuentes de archivos y hemerotecas, es posible reconstruir la historia y la fortuna crítica de esta iniciativa.
El testamento de la marquesa del Ràfol. Concepción Castellví (1783-1847), un testimonio desconocido del coleccionismo artístico a principios del sigl…
2021
María de la Concepción Castellví y Cardona, marquesa del Ràfol, falleció en 1847 dejando una gran fortuna: vínculos patrimoniales en explotación, junto a bienes muebles, plata, alhajas, su biblioteca y una importante colección pictórica. La marquesa pertenecía a la más antigua nobleza valenciana vinculada a los círculos ilustrados y a instituciones como la Real Academia de Bellas Artes de San Carlos de València. Ella misma fue gran aficionada a la pintura e ingresó como académica de mérito en la entidad a la que legó algunas obras. En su testamento nombró administrador a José María Vera dando orden de que a su muerte se formalizara «un escrupuloso inventario y justiprecio de todos sus biene…
Letting Art Teach Aesthetics, Math and Language
2020
This papers presents a practical work model as well as an educational theory discussion on the status and potential of art work in teaching and learning math in early childhood education. The central idea is to let the child’s free creative art activity reveal, or “teach”, whatever mathematical thinking was inherent in the creative process. Paying careful attention to art and math adequate language in “meta talks” with children about their art work, is found to be a rich tool in enhancing the young learner’s development of aesthetic, numeric and linguistic literacies in gainful interplay. A field study in preschool teacher education is reviewed, including a mapping of Alan Bishop’s [2] math…
Performers’ experienced emotions in the construction of expressive musical performance: An exploratory investigation
2010
Does a performer feel sad when s/he performs a sad piece of music, or does s/he perform sadness? Not much is known about the relationship between felt and performed emotions in performing musicians. Some studies emphasize the importance of feeling the emotions; others underline the idea of planned expressiveness. The purpose of this study was to investigate the relationship between a performer’s experienced emotions and the construction of a musically expressive performance. Eight music students (mean age: 20.9, SD: 1.13) completed an introductory, semi-structured interview; a monitoring period during which they filled out an Individual Playing Diary; and an in-depth, semi-structured inter…
Antithrombotics and new interventions for venous thromboembolism: Exploring possibilities beyond factor IIa and factor Xa inhibition.
2021
Abstract Direct oral anti–activated factor X and antithrombin agents have largely replaced vitamin K antagonists as the standard of care in treatment of venous thromboembolism. However, gaps in efficacy and safety persist, notably in end‐stage renal disease, implantable heart valves or assist devices, extracorporeal support of the circulation, and antiphospholipid syndrome. Inhibition of coagulation factor XI (FXI) emerges as a promising new therapeutic target. Antisense oligonucleotides offer potential advantages as a prophylactic or therapeutic modality, with one dose‐finding trial in orthopedic surgery already published. In addition, monoclonal antibodies blocking activation and/or activ…
INTEGRATED EFFICACY RESULTS FROM THE PHASE 2 AND PHASE 3 STUDIES WITH CAPLACIZUMAB IN PATIENTS WITH ACQUIRED THROMBOTIC THROMBOCYTOPENIC PURPURA
2021
Objective: An integrated analysis based on the Phase 2 TITAN (NCT01151423) and Phase 3 HERCULES (NCT02553317) studies with caplacizumab (CPLZ) in acquired thrombotic thrombocytopenic purpura (aTTP) was performed to assess treatment differences on efficacy and safety outcomes that may have been undetected in the individual trials. Methodology: In both trials, patients with an acute episode of aTTP were randomized to receive CPLZ or placebo (PBO) in addition to therapeutic plasma exchange (TPE) and immunosuppression. All randomized patients from both studies were included in the integrated efficacy analyses (CPLZ: n=108; PBO: n=112), and those who received at least 1 dose of the study drug we…
PLAYING-RELATED MUSCULOSKELETAL DISORDERS IN WOODWIND, BRASS AND PERCUSSION PLAYERS: A REVIEW
2010
Performing Arts Medicine is a broad field that includes the study of medical conditions and injuries incurred by dancers, instrument musicians and vocalists. Musicians' playing-related health problems have focused more and more the interest of scientists, researchers, physicians, physiotherapists and, in generally, of health care professionals during the last decades. The most relevant Performing Arts Medicine's literature of approximately the past twenty years has been summarized. Special attention has been given to studies concerning playing-related musculoskeletal conditions of musicians. Overuse syndrome is the most reported diagnosis among instrumental musicians suffering from playing-…
Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells
2012
Zoledronic acid (ZOL) is the most potent nitrogen-containing bisphosphonate (N-BPs) that strongly binds to bone mineral and acts as a powerful inhibitor of bone resorption, already clinically available for the treatment of patients with osteolytic metastases. Recent data also suggest that ZOL, used in breast cancer, may provide more than just supportive care modifying the course of the disease, though the possible molecular mechanism of action is still unclear. As breast cancer is one of the primary tumours with high propensity to metastasize to the bone, we investigated, for the first time, differential gene expression profile on Michigan Cancer Foundation-7 (MCF-7) breast cancer cells tre…
Control of murine hair follicle regression (catagen) by TGF‐β1in vivo
2000
The regression phase of the hair cycle (catagen) is an apoptosis-driven process accompanied by terminal differentiation, proteolysis, and matrix remodeling. As an inhibitor of keratinocyte proliferation and inductor of keratinocyte apoptosis, transforming growth factor beta1 (TGF-beta1) has been proposed to play an important role in catagen regulation. This is suggested, for example, by maximal expression of TGF-beta1 and its receptors during late anagen and the onset of catagen of the hair cycle. We examined the potential involvement of TGF-beta1 in catagen control. We compared the first spontaneous entry of hair follicles into catagen between TGF-beta1 null mice and age-matched wild-type …
Human Prostate Cancer: A Direct Role for Oestrogens
2007
We have studied the response to oestrogen and expression of oestrogen receptors in responsive LNCaP and androgen non-responsive PC3 human prostate cancer cell lines. Growth of LNCaP cells is significantly stimulated by physiological concentrations of oestradiol; this growth increase appears to be comparable to that induced by either testosterone or dihydrotestosterone. In contrast, oestradiol significantly inhibits the proliferation of PC3 cells. We also present novel evidence for functional oestrogen binding in LNCaP cells. This evidence was first obtained by means of radioligand binding assays and was further corroborated using: (a) immunocytochemical analysis of oestrogen and progesteron…