Search results for "Forming."

Is TGF-β1 a Biomarker of Huntington’s Disease Progression?

2021

Huntington’s disease (HD) is an autosomal dominant genetic disease that can be divided into preclinical and symptomatic stages. Due to the diverse HD phenotype, there is an urgent need to identify markers that would independently assess its severity. The aim of this study was to evaluate the use of plasma levels of TGF-β1 in the assessment of HD severity. One hundred HD patients and 40 healthy volunteers were included in the study. All HD patients underwent neurological and cognitive function assessment. TGF-β1 levels were determined in the plasma of all patients. The correlations between TGF-β1 levels and clinical profile and HD severity were also investigated. In symptomatic patients, cog…

Immunoistochemical expression of PD-1 and PD-L1 in bone marrow biopsies of patients with acute myeloid leukemia

2020

Background. Haematological and non-haematological malignancies are able to escape the host immune by the capacity to hijack the immune check-points. Several immune check-point molecules are known, such as T cell immunoglobulin mucin-3 (TIM-3), cytotoxic T-cell antigen-4 (CTLA-4), programmed death-1 (PD-1) with its ligand PD-L1 and others.1 The function of these immune check-points is to prevent the damage resulting from an excessive activation of the immune response in the setting of chronic antigenic stimulation, thus leading to autoimmune phenomena, as proved in knock-out mice models. PD-1 is normally present on activated T lymphocytes membrane, acting as a negative costimulatory receptor…

Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: Gender oriented diagn…

2020

Abstract Background and objectives The research of opportune strategies for facilitating the management of complex pathologies, such as ascending aorta aneurysm (AAA), currently represents the principal object of clinicians, clinical pathologists included. Herein, we propose genotyping of gene variants related to TGF-β pathway as useful strategy to improve the complex AAA management, exclusively based on imaging evaluations. Precisely, we investigated four functional SNPs in SMAD and VEGF genes, encoding molecules able to modulate functions and cross-talks of TGF-β pathway. Populations and methods Our study included 92 individuals (70 men (76%) and 22 (24%) women; mean age: 71.4 ± 2.6 years…

El diagnóstico de la crisis de la cultura en España: del recorte público a la crisis sistémica

2016

Since its invention in the fifties, cultural policy has been subject of analysis and reflection by Social Sciences. However, Spain, due to Franco period, has a number of distinguishing features as compared to Western European democracies. With the restoration of democracy, Spain acquires the dominant paradigm of a democratic cultural policy based on freedom, pluralism and the right to culture. However, after decades of democratic governments, diagnosis of cultural policy in Spain shows signs of systemic crisis, added to the impact of the global financial crisis at the beginning of the XXI century. In this context, scholars, using the Delphi method along with secondary sources, identify a se…

2019

Phobalysin P (PhlyP, for photobacterial lysin encoded on a plasmid) is a recently described small β-pore forming toxin of Photobacterium damselae subsp. damselae (Pdd). This organism, belonging to the family of Vibrionaceae, is an emerging pathogen of fish and various marine animals, which occasionally causes life-threatening soft tissue infections and septicemia in humans. By using genetically modified Pdd strains, PhlyP was found to be an important virulence factor. More recently, in vitro studies with purified PhlyP elucidated some basic consequences of pore formation. Being the first bacterial small β-pore forming toxin shown to trigger calcium-influx dependent membrane repair, PhlyP ha…

The magic of patriarchal oppression in Alan Moore and Eddie Campbell’s From Hell

2017

ABSTRACTIn From Hell, Alan Moore establishes systemic patriarchal sexual violence against the backdrop of Victorian London. While rape and other acts of physical repression are easily linked to the notion of sexual violence, Moore’s treatment is concentrated on the society as a whole. His anti-hero, physician Sir William Gull, justifies the serial murders and dissection rituals as a necessary continuation of Victorian inequality and as a symbolic manifestation of patriarchy’s counterattack. Linking ancient religion and mythology to a thousand years of British history, the sexual violence in From Hell is cast in the frame of a successful victory of patriarchy over matriarchy. Alan Moore’s pa…

Prácticas culturales y espacios públicos como lugares de interacción social y política. Un análisis de activismo y de crítica festiva en Barcelona y …

2021

espanolEl desarrollo de las grandes ciudades se ha constituido como un fenomeno global, reduciendo las posibilidades de generar convivencia en el espacio social. La busqueda actual por conectar la escala micropolitica de estos espacios con sus habitantes reconfigura el sentido de pertenencia a la ciudad. Esta aspiracion, muchas veces, desemboca en formas activas de desobediencia social en el espacio publico o, por contraposicion, de acciones que perpetuan la reproduccion de practicas culturales conservadoras. Desde esta mirada el presente trabajo se propone analizar algunas practicas culturales que ubican la participacion en el espacio publico como protagonista. Por un lado, acciones artivi…

Supplemental Material, Appendices_(1) - Is it me or the music? Stress reduction and the role of regulation strategies and music

2019

Supplemental Material, Appendices_(1) for Is it me or the music? Stress reduction and the role of regulation strategies and music by Margarida Baltazar, Daniel Västfjäll, Erkin Asutay, Lina Koppel and Suvi Saarikallio in Music & Science

Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells

2017

Spray-dried microparticles of a derivative of hyaluronic acid (HA) have been engineered to obtain a controlled aggregation with Human Mesenchymal Stem Cells (hMSCs) into 3D constructs. We demonstrated the utility of chemical functionalization of a native constituent of the extracellular matrix to improve processing performances and to control on stem cell adhesion and differentiation. Native hyaluronic acid (HA), cell adhesive peptides (RGD), transforming growth factor β3, dexamethasone are biological agents potentially suitable for chondrogenic stimulation of hMSCS. However unmodified HA suffers of drawbacks in terms of stability and versatility of processing. Functionalization strategies…

Musical training predicts cerebello-hippocampal coupling during music listening.

2018

Cerebello-hippocampal interactions occur during accurate spatiotemporal prediction of movements. In the context of music listening, differences in cerebello-hippocampal functional connectivity may result from differences in predictive listening accuracy. Using functional MRI, we studied differences in this network between 18 musicians and 18 nonmusicians while they listened to music. Musicians possess a predictive listening advantage over nonmusicians, facilitated by strengthened coupling between produced and heard sounds through lifelong musical experience. Thus, we hypothesized that musicians would exhibit greater functional connectivity than nonmusicians as a marker of accurate online pr…