Search results for "Forming."
showing 10 items of 1704 documents
Tactics of invisibility : How people in vulnerable positions make datafied everyday life livable
2022
Various data platforms force the individual into constant presence and visibility. However, the ways in which datafied environments relate to experienced vulnerabilities in our everyday lives remain unclear. Through diaries produced by and interviews with participants from three groups who occupy presumably vulnerable positions and who currently live in Finland, we explore the ways in which people challenge expectations and prior assumptions related to forced visibility. Using the concept of tactics developed by de Certeau, we aim to understand how individuals make everyday surveillance culture livable through what we call tactics of invisibility. Based on our analysis, we identify three k…
Latvijas Vēstures Institūta Žurnāls. 2022, Nr. 1 (115)
2022
LU Latvijas vēstures institūta LU ilgtermiņa saistību izpildei 2020.-2022. g. ("Latvijas Vēstures Institūta Žurnāls")
Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study.
2013
We previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036. These strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low pH. In the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy volunteers in three Spanish cities was carried out to evaluate the tolerance, safety, gut colonization and immunomodulatory effects of these three probiotics. Volunteers underwent a 15-day washout perio…
Tur e Iraj, Caín y Abel: Semejanzas iconográficas en la interminable lucha del mal y el bien.
2015
ABSTRACT: The duality between good and evil is a common topic in all civilizations regardless of chronology or geographical location. It is a conflict reflected in art history, and on the present occasion, through the iconographic types of Cain killing Abel as well as Tur murdering Iraj. The roots of these myths are deeply embedded in two highly relevant written sources, the Bible and the Shahnameh or The Book of Kings . The latter was written by the great Iranian poet Ferdowsi. The legends, despite having different origins, nevertheless have many similarities and they share a particular iconographic type. I analyze each of the myths along with their pictorial representations, which connec…
Combining gestures and vocalizations to imitate sounds
2015
International audience; Communicating about sounds is a difficult task without a technical language, and naïve speakers often rely on different kinds of non-linguistic vocalizations and body gestures (Lemaitre et al. 2014). Previous work has independently studied how effectively people describe sounds with gestures or vocalizations (Caramiaux, 2014, Lemaitre and Rocchesso, 2014). However, speech communication studies suggest a more intimate link between the two processes (Kendon, 2004). Our study thus focused on the combination of manual gestures and non-speech vocalizations in the communication of sounds. We first collected a large database of vocal and gestural imitations of a variety of …
Comparing identification of vocal imitations and computational sketches of everyday sounds
2016
International audience; Sounds are notably difficult to describe. It is thus not surprising that human speakers often use many imitative vocalizations to communicate about sounds. In practice,vocal imitations of non-speech everyday sounds (e.g. the sound of a car passing by) arevery effective: listeners identify sounds better with vocal imitations than with verbal descriptions, despite the fact that vocal imitations are often inaccurate, constrained by the human vocal apparatus. The present study investigated the semantic representations evoked by vocal imitations by experimentally quantifying how well listeners could match sounds to category labels. Itcompared two different types of sounds…
Genotypic and Phenotypic Characteristics of Acute Promyelocytic Leukemia Translocation Variants.
2020
Acute promyelocytic leukemia (APL) is a special disease entity of acute myeloid leukemia (AML). The clinical use of all-trans retinoic acid (ATRA) has transformed APL into the most curable form of AML. The majority of APL cases are characterized by the fusion gene PML-RARA. Although the PML-RARA fusion gene can be detected in almost all APL cases, translocation variants of APL have been reported. To date, this is the most comprehensive review of these translocations, discussing 15 different variants. Reviewed genes involved in APL variants include: ZBTB16, NPM, NuMA, STAT5b, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMDTS17, STAT3, and TFG. The genotypic and phenotypic …
Controversies on the role of Th17 in cancer: a TGF-β-dependent immunosuppressive activity?
2012
The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known, their roles in cancer remain ambiguous. Despite adoptive transfer studies indicating that mouse Th17 cells support anticancer immunity, the Th17 cells that naturally infiltrate experimental tumors appear to have a tumor-promoting effect. These contradictory properties can be related to the high degree of plasticity inherent in Th17 cells and their capacity to differentiate into tumoricidal Th1-like cells. Mouse Th17 cells induced by transfo…
Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression
2012
International audience; Although Th17 cells are known to promote tissue inflammation and autoimmunity, their role during cancer progression remains elusive. Here, we showed that in vitro Th17 cells generated with the cytokines IL-6 and TGF-β expressed CD39 and CD73 ectonucleotidases, leading to adenosine release and the subsequent suppression of CD4(+) and CD8(+) T cell effector functions. The IL-6-mediated activation of the transcription factor Stat3 and the TGF-β-driven downregulation of Gfi-1 transcription factor were both essential for the expression of ectonucleotidases during Th17 cell differentiation. Stat3 supported whereas Gfi-1 repressed CD39 and CD73 expression by binding to thei…
Coexpression of TGF-β1 and IL-10 Enables Regulatory T Cells to Completely Suppress Airway Hyperreactivity
2008
Abstract In allergic airway disease, Treg may play an important role in the modulation of airway hyperreactivity (AHR) and inflammation. We therefore investigated the therapeutic potential of Treg in an Ag-dependent murine asthma model. We here describe that AHR can be completely suppressed by adoptive transfer of Treg overexpressing active TGF-β1. Using mice with impaired TGF-β signaling in T cells, we could demonstrate that TGF-β signaling in recipient effector T cells or transferred Treg themselves is not required for the protective effects on AHR. However, the expression of IL-10 by Treg was found to be essential for the suppression of AHR, since Treg overexpressing active TGF-β1 but de…