Search results for "Forming."
showing 10 items of 1704 documents
Pre- and Post-translational Regulation of Lysyl Oxidase by Transforming Growth Factor-β1 in Osteoblastic MC3T3-E1 Cells
1995
The final enzymatic step required for collagen cross-linking is the extracellular oxidative deamination of peptidyl-lysine and -hydroxylysine residues by lysyl oxidase. A cross-linked collagenous extracellular matrix is required for bone formation. The goals of this study were to compare the transforming growth factor (TGF)-beta 1 regulation of lysyl oxidase enzyme activity and steady state mRNA levels to changes in COL1A1 mRNA levels in MC3T3-E1 osteoblastic cells. TGF-beta 1 increased steady state lysyl oxidase and COL1A1 mRNA levels in a dose- and time-dependent manner. The increase in lysyl oxidase mRNA levels was transient, peaking at 12 h and 8.8 times controls in cells treated with 4…
Influence of Geometrical Parameters, Wall Angle and Part Shape on Thickness Reduction of Single Point Incremental Forming
2014
Abstract The aim of this paper is to study the thickness reduction during the whole single point incremental forming process. The experimental setup is realized in such a way that the blank sheet is in the vertical position and forming is done using an anthropomorphic robot with six degrees of freedom. The vertical positioning of the blank sheet allows the on-line visualization using an optical measuring system of the major and minor strains and of the thickness reduction. The wall angle varied between values of 45 0 , 55 0 and 65 0 respectively. The logarithmic major strain and minor strains and logarithmic thickness reduction were analyzed in order to allow a comparison with values obtain…
Meshless Simulation of Friction Stir Welding
2007
This paper encompasses our first efforts towards the numerical simulation of friction stir welding by employing a Lagrangian approach. To this end, we have employed a meshless method, namely the Natural Element Method (NEM). Friction Stir welding is a welding process where the union between the work pieces is achieved through the extremely high deformation imposed by a rotating pin, which moves between the two pieces. This extremely high strain is the main responsible of the difficulties associated with the numerical simulation of this forming process. Eulerian and Arbitrary Lagrangian-Eulerian (ALE) frameworks encounter difficulties in some aspects of the simulation. For instance, these ap…
Les IAP au cœur de la signalisation NF-κB
2012
The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells
2007
Abstract Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control the balance between tolerance and immunity. Alternatively, activated immune cells might prevent the induction or activation of Tregs in such diseases. In this study, we demonstrate that trans-signaling into T cells via the soluble IL-6 receptor completely abrogates the de novo induction of adaptive Tregs. Mechanistically, IL-6 trans-signaling augmented the expression of the TGF-β signaling inhibitor SMAD7. Consequently, SMAD7 overexpression in T cells using newly created transgenic mice rendered CD4+CD25− T cells resistant to the induction of FoxP3. Finally, IL-6 trans-signaling inhibited Treg…
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation
2005
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferation of naturally occurring CD25+ T cells and requires signaling through transforming growth factor (TGF)–β receptor II. During tumor progression, a subset of dendritic cells (DCs) exhibiting a myeloid immature phenotype is recruited to draining lymph nodes. This DC subset selectively promotes the proliferation of T reg cells in a TGF-β–dependent manner in mice and rats. Tumor cells are necessary a…
On Analytical vs . Schizophrenic Procedures for Computing Music
2009
The authors present a perspective on computer music, which is based on some particular definitions of music in relation to oral culture and cybernetics. They describe some experiments with different models of neural architectures which generate original music, and then suggest that if such neural systems are rich, effective and intuitive enough to produce ‘live’ music, the understanding of their behaviour may require the development of some ‘schizophrenic’ procedures, as well as analytical ones.
Tres pinturas valencianas inéditas de Joanes, Requena y Espinosa
2015
El objetivo de este breve estudio es dar a conocer tres pintu- ras pertenecientes a obradores valencianos de los siglos XVI y XVII que, dispersas y en el mercado del arte, muestran su relación con la órbita de Joan de Joanes, Gaspar Requena y Jerónimo Jacinto de Espinosa.
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
RESHAPING AS NOVEL CIRCULAR ECONOMY STRATEGY FOR SHEET METAL BASED END-OF-LIFE COMPONENTS
2022
Making materials consumes about 21% of the global energy demand a specifically metals production, it accounts for about 8% of total global energy consumption. In fact, in the past few decades, the use of lightweight alloys has become increasingly widespread in many major industrial sectors thanks to the weight reduction associated with their applications. Most lightweight materials like aluminum alloys are characterized by high-energy demands primary production cycles that are responsible for a relevant share of the global CO2 emissions. Circular economy strategies such us longer life, more intense use, repair, product upgrades, modularity, remanufacturing, component re-use and open/closed …