Search results for "Forming"
showing 10 items of 1719 documents
Steroid-growth factor interaction in human prostate cancer. 1. Short-term effects of transforming growth factors on growth of human prostate cancer c…
1994
In order to better define potential mechanisms of growth regulation in human prostate cancer cells, we have compared biological responses (such as short-term response to both transforming growth factor alpha and beta; TFG alpha and TFG beta) in relation to hormone sensitivity of LNCaP, DU145, and PC3 cells. Androgen receptor (AR) and epidermal growth factor receptor (EGF-R) content of each cell line was also investigated. In addition, expression of EGF, TGF alpha, and TGF beta was evaluated through immunofluorescent staining. Growth of androgen non-responsive PC3 cells was stimulated by TGF alpha (about 35%) and inhibited by TGF beta (more than 50%), with respect to controls, after 48 h exp…
Microvascular effects of the inhibition of dipeptidylpeptidase IV by linagliptin in nondiabetic hypertensive patients
2015
Recent studies suggest vascular benefits of dipeptidylpeptidase IV (DPP-IV) inhibition in patients with diabetes mellitus. Only little is known about potential vascular effects of DPP-IV inhibitors in nondiabetic individuals. The aim of this study was to investigate the effect of DPP-IV inhibition in a nondiabetic hypertensive population.This was a double-blinded, randomized, placebo-controlled, mechanistic study, comparing microvascular effects of the DPP-IV inhibitor linagliptin with placebo in nondiabetic individuals with a history of arterial hypertension. Twenty-one patients received 5 mg linagliptin (5 women; age 67.6 ± 6.0 years; mean ± SD), whereas 22 patients were randomized to pla…
Steroid-growth factor interaction in human prostate cancer. 2. Effects of transforming growth factors on androgen metabolism of prostate cancer cells
1996
The ability of human prostate cancer cells to metabolize androgens was assessed through administration of physiological concentration (0.5-10 nM) of tritiated testosterone (T) as precursor and one-step analysis of both T degradation and products' formation by reverse-phase HPLC and on-line radioactive detection after either 24 h or 72 h incubation. Overall, different prostate cancer cells degraded T quite differently, favoring alternatively reductive or oxidative metabolic pathways. In particular, both LNCaP and DU145 cells retained high levels of unconverted T, with a limited production of androstenedione and its 17-keto derivatives and relatively high amounts of dihydrotestosterone (DHT) …
Rac1 GTPase, a multifunctional player in the regulation of genotoxic stress response
2013
The Ras-related C3 botulinum toxin substrate 1 (Rac1) belongs to the Ras-homologous (Rho) family of small GTPases, which transduce signals from the outside to the inside of a cell. Rac1 becomes activated upon ligand binding of a variety of receptors, including receptor tyrosine kinases and heterotrimeric G-protein-coupled receptors. After GTP loading by guanine exchange factors (GEFs), GTP-bound Rac1 engages numerous effector proteins, thereby eventually regulating cell motility and adhesion, cell cycle progression through G1, mitosis and meiosis, as well as cell death and metastasis.1 Besides, Rac1 adjusts cellular responses to genotoxic agents, such as UV light and alkylating agents, by r…
Information acquisition in SME's relationship lending and the cost of loans
2015
Abstract This study analyzes the effect of the reputation SMEs get in a relationship lending on the cost of next loans. A unique dataset of 734 Spanish SMEs' relationship lending provides information on a loan-by-loan basis about the ex post previous loan performance, which measures reputation. No prior empirical research differentiates the cost of loans following a defaulted loan from the costs of those following a successfully repaid loan. Results show that lenders obtain information about borrowers' risk-level during relationship lending and use this information. Loans granted after a successful one pledge significantly lower collateral and interest rate than loans granted after a defaul…
Marketing de l'Art et de la Culture
2009
2e édition; International audience; Les organisations culturelles modernes ont besoin d'une démarche et d'outils marketing rigoureux adaptés à leurs spécificités. Cet ouvrage de référence poursuit un double objectif : éclairer le lecteur sur les caractéristiques du secteur et définir les enjeux stratégiques et outils opérationnels du marketing dans les principaux domaines des arts et de la culture (spectacle vivant, patrimoine, industries culturelles). Dans le secteur des arts et de la culture le marketing souffre d'un fort déficit d'image. Pourtant qu'il s'agisse de lancer des projets, de nouer des relations avec des partenaires, d'attirer et de fidéliser des publics, de démocratiser l'acc…
Advanced numerical models for the thermo-mechanical-metallurgical analysis in hot forging processes
2013
In the paper a literature review of the numerical modeling of thermo-mechanical-metallurgical evolutions of a metal in hot forging operations is presented. In particular models of multiaxial loading tests are considered for carbon steels. The collected examples from literature regard phases transformations, also martensitic transformations, morphologies evolutions and transformation plasticity phenomena. The purpose of the tests is to show the correlation between the mechanical and the metallurgical behavior of a carbon steel during a combination of several types of loads. In particular a few mechanical tests with heat treatment are analyzed. Furthermore, Ti-6Al-4V titanium alloy is conside…
Numerical simulation of material failure in single point incremental forming process
2019
Abstract The sheet metal parts obtained through single point incremental forming process show a thinning and also there is a high possibility of material failure. In order to avoid the failure of the material during the process, it is a good practice to use numerical simulation through finite element method to prevent this phenomenon. The aim of this paper is to investigate the prediction of the failure moment of the aluminium sheet metal using various failure criteria. Commonly used failure criteria are: Tresca or maximum shear stress criterion, von Mises yield criterion, Hill yield criteria and various invariants of the Cauchy stress tensor. For the numerical simulation of the single poin…
Forming of aluminum foam sandwich panels: Numerical simulations and experimental tests
2006
Abstract The forming of the completed aluminium foam sandwich (AFS) panels would determine an improvement in the manufacturing of parts and panels. In this paper the authors have investigated the formability of AFS through experiments and numerical simulations. As far as the former are concerned, commercially prepared panels have been considered and bending and stamping processes have been taken into account. In addition, FEM analyses have been developed, utilizing a porous material model following the evolution of the material density throughout the forming processes.
MICRO-SCALE STUDY OF RESIDUAL STRESSES IN CR2O3 COATINGS SPRAYED BY APS
2020
International audience; Whichever the application field, every material forming process generates residual stresses on the surface. While they are likely to enhance the aimed properties of the final mechanical part, these stresses may also drastically reduce them and result in early failures. Therefore, understanding the residual stress state remains a major challenge when coating complex parts, especially as most characterization methods at the microscopic scale involve specific sample preparation procedures which may affect the residual stresses field. This work investigates the residual stress state that exists in chromium oxide coatings deposited via Atmospheric Plasma Spray (APS), usin…