Search results for "Forming"

Health Literate Child: Transforming Teaching in School Health Education

2015

<p><em>Health literacy and health education are reciprocally connected concepts in modern scientific discourse. Educational institutions, especially schools, are defined as one of the main arenas for the development and promotion of the child’s health literacy. Thus, health literacy, conceptualized as the outcome of school learning, becomes the aim of school health education. As concept of health literacy becomes more complicated its attainment requires more advanced and specific teaching methods, which, in its turn, demands transformations in teacher education and teachers’ professional development as well as to perceive the child as an active participant in the teaching/learni…

Political Performances: Theory and Practice. Edited by Susan C. Haedicke, Deirdre Heddon, Avraham Oz and E. J. Westlake. Amsterdam and New York: Rodo…

2010

An Interview with Giorgio Grassi

2007

In January 2007, Lucia Tozzi visited Giorgio Grassi's office in Milan. Their conversation touched on Grassi's recent work on Leon Battista Alberti, which is examined here in the context of Grassi's obliquely expressed views on contemporary architecture and the cult of personality. As perhaps the most intellectually rigorous and formally consistent Rationalist architect of his generation, Grassi's work and thinking retain a hermetic aspect, but one notable for its philosophical self-questioning and underlying political commitment. Copyright © 2007 John Wiley & Sons, Ltd.

Clostridium perfringens (Holland) as an indicator of human effluent in the sediment of Lake Tuomiojärvi, central Finland

1983

The horizontal and vertical distribution of the gram-positive, non-motile, spore-forming and rod-shaped bacterium Clostridium perfringens Holland was studied. The aim of the study was to estimate the quantity of C. perfringens at different depths of the sediment and evaluate the effect of human effluent which the lake received between 1940 and 1956. C. perfringens lives in the colon of man. Because it is spore forming and cannot multiply under a temperature of 20 °C and, according to the studies of Seppanen et al. (1979) it can be at least 300 years old, it may be a suitable paleolimnological indicator of pollution by human effluent.

A Comparison between Three Meta-Modeling Optimization Approaches to Design a Tube Hydroforming Process

2012

Computer aided procedures to design and optimize forming processes have become crucial research topics as the industrial interest in cost and time reduction has been increasing. A standalone numerical simulation approach could make the design too time consuming while meta-modeling techniques enables faster approximation of the investigated phenomena, reducing the simulation time. Many researchers are, nowadays, facing such research challenge by using various approaches. Response surface method (RSM) is probably the most known one, since its effectiveness was demonstrated in the past years. The effectiveness of RSM depends both on the definition of the Design of Experiments (DoE) and the acc…

FEM Simulation of Laminated Lightweight Materials Processed through Single Point Incremental Forming

2015

The aim of present paper is to realize the FEM simulation of laminated lightweight material processed through single point incremental forming. Thus a laminated material, aluminum - polypropylene - aluminum (Al-PP-Al), as sheet 1.2 mm thickness was used. For these material the hardening curve was determinate. These values were used to describe elastic-plastic behavior of the material during single point incremental forming process simulation. Single point incremental forming process simulation aimed to assess the distribution of values and maximum and minimum strains, the material thickness of the specimen and the technological force for the two strategies for obtaining the truncated cone s…

Zn-Enhanced Asp-Rich Antimicrobial Peptides N-Terminal Coordination by Zn(II) and Cu(II), Which Distinguishes Cu(II) Binding to Different Peptides

2021

The antimicrobial activity of surfactant-associated anionic peptides (SAAPs), which are isolated from the ovine pulmonary surfactant and are selective against the ovine pathogen Mannheimia haemolytica, is strongly enhanced in the presence of Zn(II) ions. Both calorimetry and ITC measurements show that the unique Asp-only peptide SAAP3 (DDDDDDD) and its analogs SAAP2 (GDDDDDD) and SAAP6 (GADDDDD) have a similar micromolar affinity for Zn(II), which binds to the N-terminal amine and Asp carboxylates in a net entropically-driven process. All three peptides also bind Cu(II) with a net entropically-driven process but with higher affinity than they bind Zn(II) and coordination that involves the N…

A lipocentric view of peptide-induced pores

2010

Although lipid membranes serve as effective sealing barriers for the passage of most polar solutes, nonmediated leakage is not completely improbable. A high activation energy normally keeps unassisted bilayer permeation at a very low frequency, but lipids are able to self-organize as pores even in peptide-free and protein-free membranes. The probability of leakage phenomena increases under conditions such as phase coexistence, external stress or perturbation associated to binding of nonlipidic molecules. Here, we argue that pore formation can be viewed as an intrinsic property of lipid bilayers, with strong similarities in the structure and mechanism between pores formed with participation …

Functional size of complement and perforin pores compared by confocal laser scanning microscopy and fluorescence microphotolysis

1991

Abstract Confocal laser scanning microscopy and fluorescence microphotolysis (also referred to as fluorescence photobleaching recovery) were employed to study the transport of hydrophilic fluorescent tracers through complement and perforin pores. By optimizing the confocal effect it was possible to determine the exclusion limit of the pores in situ, i.e. without separation of cells and tracer solution. Single-cell flux measurements by fluorescence microphotolysis yielded information on the sample population distribution of flux rates. By these means a direct comparison of complement and perforin pores was made in sheep erythrocyte membranes. In accordance with previous studies employing a v…

Pore-forming toxins activate MAPK p38 by causing loss of cellular potassium.

2009

Mitogen activated protein kinase (MAPK) p38 has emerged as a survival protein in cells that are attacked by bacterial toxins forming small membrane pores. Activation of p38 by pore forming toxins (PFT) has been attributed to osmotic stress, but here we show that loss of K+ is likely to be the critical parameter. Several lines of evidence support this conclusion: first, osmoprotection did not prevent p38-phosphorylation in alpha-toxin-loaded cells. Second, treatment of cells with a K+ ionophore, or simple incubation in K+-free medium sufficed to cause robust p38-phosphorylation. Third, media containing high [K+] prevented p38-activation by Staphylococcus aureus alpha-toxin, Vibrio cholerae c…