Search results for "Forming"
showing 10 items of 1719 documents
Les IAP au cœur de la signalisation NF-κB
2012
The function of IAP has long been limited to an inhibition of apoptosis through their capacity to bind some caspases. Since the expression of these proteins is altered in some tumor samples, IAPs are targets for anticancer therapy and many small molecules have been designed for their capacity to inhibit IAP-caspase interaction. Unexpectedly, these molecules appeared to significantly affect NF-κB activation. In this review, we will discuss the central role of cIAP1, cIAP2 and XIAP in the regulation of NF-κB activating signaling pathways.
Cutting Edge: Trans-Signaling via the Soluble IL-6R Abrogates the Induction of FoxP3 in Naive CD4+CD25− T Cells
2007
Abstract Chronic inflammatory diseases may develop when regulatory T cells (Tregs) fail to control the balance between tolerance and immunity. Alternatively, activated immune cells might prevent the induction or activation of Tregs in such diseases. In this study, we demonstrate that trans-signaling into T cells via the soluble IL-6 receptor completely abrogates the de novo induction of adaptive Tregs. Mechanistically, IL-6 trans-signaling augmented the expression of the TGF-β signaling inhibitor SMAD7. Consequently, SMAD7 overexpression in T cells using newly created transgenic mice rendered CD4+CD25− T cells resistant to the induction of FoxP3. Finally, IL-6 trans-signaling inhibited Treg…
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation
2005
The mechanisms through which regulatory T cells accumulate in lymphoid organs of tumor-bearing hosts remain elusive. Our experiments indicate that the accumulation of CD4+CD25+ regulatory T cells (T reg cells) expressing FoxP3 and exhibiting immunosuppressive function originates from the proliferation of naturally occurring CD25+ T cells and requires signaling through transforming growth factor (TGF)–β receptor II. During tumor progression, a subset of dendritic cells (DCs) exhibiting a myeloid immature phenotype is recruited to draining lymph nodes. This DC subset selectively promotes the proliferation of T reg cells in a TGF-β–dependent manner in mice and rats. Tumor cells are necessary a…
On Analytical vs . Schizophrenic Procedures for Computing Music
2009
The authors present a perspective on computer music, which is based on some particular definitions of music in relation to oral culture and cybernetics. They describe some experiments with different models of neural architectures which generate original music, and then suggest that if such neural systems are rich, effective and intuitive enough to produce ‘live’ music, the understanding of their behaviour may require the development of some ‘schizophrenic’ procedures, as well as analytical ones.
Tres pinturas valencianas inéditas de Joanes, Requena y Espinosa
2015
El objetivo de este breve estudio es dar a conocer tres pintu- ras pertenecientes a obradores valencianos de los siglos XVI y XVII que, dispersas y en el mercado del arte, muestran su relación con la órbita de Joan de Joanes, Gaspar Requena y Jerónimo Jacinto de Espinosa.
Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes.
2020
Background: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic Mboat7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2 hepatocytes. Findings: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammatio…
RESHAPING AS NOVEL CIRCULAR ECONOMY STRATEGY FOR SHEET METAL BASED END-OF-LIFE COMPONENTS
2022
Making materials consumes about 21% of the global energy demand a specifically metals production, it accounts for about 8% of total global energy consumption. In fact, in the past few decades, the use of lightweight alloys has become increasingly widespread in many major industrial sectors thanks to the weight reduction associated with their applications. Most lightweight materials like aluminum alloys are characterized by high-energy demands primary production cycles that are responsible for a relevant share of the global CO2 emissions. Circular economy strategies such us longer life, more intense use, repair, product upgrades, modularity, remanufacturing, component re-use and open/closed …
Mapping Art History in the Digital Era
2021
Just as for the rest of the humanities, a roadmap for the discipline of art history in the past few decades would show a tangle of unexpected turns. Art history has undergone the linguistic turn, the material turn, the pictorial turn, the global turn, and, of course, the spatial turn, to name a few; what is more, there is the discipline's recent convergence with digital technologies. Already in 2004, while reviewing two recent contributions to the field, Larry Silver could assert in The Art Bulletin that "art is created as much in place as in time, making some self-aware form of artistic geography essential to the future of the discipline."1 Much more recently, Paul Jaskot hailed spatial an…
Reflexiones sobre el pintor Lluís Dalmau a propósito de un retablo para Molins de Rei (1451)
2018
El presente texto plantea una serie de reflexiones sobre la figura del pintor Lluís Dalmau, uno de los introductores de la pintura gótica flamenca en la Corona de Aragón. El análisis surge a partir de la presentación de un nuevo documento inédito sobre un retablo contratado en 1451 por Isabel de Requesens, esposa del gobernador de Cataluña, Galceran de Requesens, para la baronía de Molins de Rei (Barcelona). El documento sitúa al pintor realizando este encargo en Valencia, lo que supone un regreso hasta ahora desconocido a su ciudad natal tras haber realizado la tabla de la Mare de Déu dels Consellers, de Barcelona (1443-1445), y el retablo de san Baudilio, de Sant Boi de Llobregat (1448). …
Influence of some relevant process parameters on the dimensional accuracy in incremental forming: a numerical and experimental investigation
2004
Abstract As known, incremental forming is a flexible and innovative sheet metal forming process which allows complex shape shells forming without the need for any die. For these reasons, incremental forming is nowadays suggested for rapid prototyping and customised products. The present paper is focused on material formability in incremental forming and, in particular, on the evaluation and compensation of elastic springback. The latter significantly modifies the imposed shape. For this purpose, a deeper assessment of the process was developed following three different approaches. First of all, a wide experimental investigation on the influence of some relevant process parameters was develo…