Search results for "Forms"
showing 10 items of 668 documents
Post-translational modifications in the survival motor neuron protein
2004
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by a progressive loss of the spinal motoneurons. The SMA-determining gene has been termed survival motor neuron (SMN) and is deleted or mutated in over 98% of patients. The encoded gene product is a protein expressed as different isoforms. In particular, we showed that the rat SMN cDNA produces two isoforms with Mr of 32 and 35 kDa, both localized in nuclear coiled bodies, but the 32 kDa form is also cytoplasmic, whereas the 35 kDa form is also microsomal. To determine the molecular relationship between these two isoforms and potential post-translational modifications, we performed transfection experiments with a …
La dimensione tecnologica del museo: forme, tecniche, "identità mutanti" tra storia e contemporaneità
2005
Nella cultura contemporanea il tema della conservazione dell’eredità storica, della rappresentazione e della trasmissibilità dell’arte è argomento ampiamente dibattuto. La forza culturale del museo, detentore dell’eredità, può essere interpretata secondo diverse traiettorie di forme. La memoria intende esprimersi sulle origini e sul significato della "macchina museale" attraverso l’analisi critica dell’oggetto, sia esso contenitore, palco di rappresentazione o scena interattiva. Sonda i processi di comunicazione relativamente alla forma architettonica, alla funzione ed alla fruizione del prodotto espositivo. Tenendo conto delle diverse scuole di pensiero sulla spettacolarizzazione dell’arte…
Automated simultaneous triple dissolution profiles of two drugs, sulphamethoxazole-trimethoprim and hydrochlorothiazide-captopril in solid oral dosag…
2003
This article deals with the simultaneous determination of three dissolution profiles with the aid of the new and emerging continuous-flow methodology known as multicommutation. This methodology is based on a flow network of a set of solenoid valves controlled by the computer and acting as independent multicommutators to allow the easy and automated control of flowing solutions. The obtained three dissolution profiles from one dosage form are the whole formulation profile or "global profile" recommended by pharmacopoeias, and, at same time, are recorded two "individual" profiles from two drugs present in the formulation. This is the second attempt to obtain simultaneously three dissolution p…
Spatial variability of channel changes in a mediterranean ephemeral stream in the last six decades (1946-2006)
2014
An analysis of morphological changes during the last six decades is presented for the Rambla de Cervera, a Mediterranean ephemeral stream located in the eastern sector of the Iberian Mountain Range. The studied channel (16.5 km) has two contrasted sectors: a horst confined sector (5.5 km) and a graben sector (11 km). Channel changes were analysed through the analysis of aerial photographs, with geographical information systems (GIS) and comparison of topographic surveys made with a GPS-RTK. Between 1946 and 2006 the Rambla de Cervera, underwent channel adjustments comparable to those observed in other Mediterranean rivers. The gravel channel markedly narrowed, losing width (68.5%) and chann…
Sequential injection analysis (SIA)-chemiluminescence determination of indomethacin using tris[(2,2'-bipyridyl)]ruthenium(III) as reagent and its app…
2006
Abstract Automated sequential injection (SIA) method for chemiluminescence (CL) determination of nonsteroidal anti-inflammatory drug indomethacin ( I ) was devised. The CL radiation was emitted in the reaction of I (dissolved in aqueous 50% v/v ethanol) with intermediate reagent tris(2,2′-bipyridyl)ruthenium(III) (Ru(bipy) 3 3+ ) in the presence of acetate. The Ru(bipy) 3 3+ was generated on-line in the SIA system by the oxidation of 0.5 mM tris(2,2′-bipyridyl)ruthenium(II) (Ru(bipy) 3 2+ ) with Ce(IV) ammonium sulphate in diluted sulphuric acid. The optimum sequence, concentrations, and aspirated volumes of reactant zones were: 15 mM Ce(IV) in 50 mM sulphuric acid 41 μL, 0.5 mM Ru(bipy) 3 …
Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
2022
AbstractAirway inflammation and remodelling are important pathophysiologic features in asthma and other respiratory conditions. An intact epithelial cell layer is crucial to maintain lung homoeostasis, and this depends on intercellular adhesion, whilst damaged respiratory epithelium is the primary instigator of airway inflammation. The Coxsackievirus Adenovirus Receptor (CAR) is highly expressed in the epithelium where it modulates cell-cell adhesion stability and facilitates immune cell transepithelial migration. However, the contribution of CAR to lung inflammation remains unclear. Here we investigate the mechanistic contribution of CAR in mediating responses to the common aeroallergen, H…
Designing a Multi‐Sided Platform business model assessment framework: a Dynamic Performance Management perspective
2019
The purpose of this research is to offer an assessment framework to validate multisided platform business models. For this aim, we propose a systemic perspective based on the dynamic performance management approach. This approach is particularly effective to make explicit the net of relationships between internal and external strategic resources, the value creation and capture drivers, and the way such drivers influence platform performances. The developed multisided platform business model assessment framework has been tested by using a success and a failure case, respectively, Airbnb and Take Eat Easy. Research originality results from the combination of multisided platform value creation…
Radon transform as a set of probability distributions
2009
It is proved that the Radon transform of the Wigner function gives the probability distributions related to measuring the observable operators obtained as linear combinations of position and momentum of the relevant particle. The generalization to an arbitrary number of degrees of freedom is given.
β1D Integrin Inhibits Cell Cycle Progression in Normal Myoblasts and Fibroblasts
1998
Integrins are alphabeta heterodimeric transmembrane receptors involved in the regulation of cell growth and differentiation. The beta1 integrin subunit is widely expressed in vivo and is represented by four alternatively spliced cytoplasmic domain isoforms. beta1D is a muscle-specific variant of beta1 integrin and a predominant beta1 isoform in striated muscles. In the present study we showed that expression of the exogenous beta1D integrin in C2C12 myoblasts and NIH 3T3 or REF 52 fibroblasts inhibited cell proliferation. Unlike the case of the common beta1A isoform, adhesion of beta1D-transfected C2C12 myoblasts specifically via the expressed integrin did not activate mitogen-activated pro…
Choosing Open Innovation Intermediaries through their web-based platforms
2016
This paper examines the services provided by Open Innovation Intermediaries (OIIs) through their web-based platforms, in order to understand how OIIs can effectively support innovation seekers in their innovation processes. Relying on the existing literature exploring the roles and functions of web-based OII platforms, we carried out an exploratory and comparative qualitative study to identify the services available, to classify them by the various phases of the innovation processes in which they can be beneficial, and to link them to general roles and functions. Our analysis of the services provided by OII platforms sheds light on the dynamics of innovation seekers’ choices, and gives mean…