Search results for "Forms"

showing 10 items of 668 documents

Dscam1 Is Required for Normal Dendrite Growth and Branching But Not for Dendritic Spacing in Drosophila Motoneurons

2014

Down syndrome cell adhesion molecule, Dscam, serves diverse neurodevelopmental functions, including axon guidance and synaptic adhesion, as well as self-recognition and self-avoidance, depending on the neuron type, brain region, or species under investigation. InDrosophila, the extensive molecular diversity that results from alternative splicing of Dscam1 into >38,000 isoforms provides neurons with a unique molecular code for self-recognition in the nervous system. Each neuron produces only a small subset of Dscam1 isoforms, and distinct Dscam1 isoforms mediate homophilic interactions, which in turn, result in repulsion and even spacing of self-processes, while allowing contact with neig…

Nervous systemGreen Fluorescent ProteinsMuscle Fibers SkeletalBiologyAnimals Genetically ModifiedDSCAMDendrite (crystal)medicineAnimalsDrosophila ProteinsProtein IsoformsMotor NeuronsAnalysis of VarianceGeneral NeuroscienceMARCMfungiGene Expression Regulation DevelopmentalArticlesDendritesAlternative Splicingmedicine.anatomical_structurenervous systemMushroom bodiesAxon guidanceDrosophilaRNA InterferenceNeuronNeuroscienceCell Adhesion MoleculesDrosophila Protein
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New Families as an Educational Emergency

2017

One phenomenon typical of late-modern Western societies is the extreme pluralisation of family forms, a true and proper archipelago of families, so that: the family can no longer be reasonably discussed in the singular, just as well as each couple seems to form a «mixed couple» . Observing the data describing this phenomenon and any perceived trends, prompt a first general consideration, from an educational perspective: the aspects related to couple formation, the choice of whether to marry, the preferred family forms, all highlight a breakup between the older and the younger generations. In short, we are confronted with a new culture of human relationships: this new culture sets new symbol…

New couple relationships New family forms The couple's being a couple From couple to family The family's being a family The family as an existential The right to an aeducational safeguardSettore M-PED/01 - Pedagogia Generale E Sociale
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Prefazione

2014

In un contesto in continua evoluzione per effetto della globalizzazione e della rivoluzione tecnologica, la definizione del concetto di devianza e l’esplorazione dei suoi cambiamenti rendono necessaria una riflessione trasversale a diversi ambiti disciplinari, attraversando il confine tra sociologia della devianza e diritto. In a changing environment as a result of globalization and technological revolution, the definition of the concept of deviance and the exploration of its changes make necessary a cross-reflection in different disciplines, crossing the border between sociology of deviance and law.

New forms of deviance Internet and control digital nativesSettore SPS/11 - Sociologia Dei Fenomeni PoliticiSettore SPS/12 - Sociologia Giuridica Della Devianza E Mutamento SocialeNuove forme di devianza Internet e controllo nativi digitali
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Viaggi nell’immaginario: il turismo virtuale nel sito UNESCO di Tarragona

2023

Le nuove tecnologie hanno trasformato in modo radicale non solo la geografia come disciplina, ma anche le geografie del mondo. Il digitale ha assunto, infatti, un ruolo di mediazione sempre più pervasivo nella produzione dello spazio, come delle conoscenze e degli immaginari geografici. Le possibilità offerte dal virtuale, in particolare, offrono oggi un contributo decisivo nella comunicazione dei significati attribuiti ai luoghi e rispondono in modo sempre più efficace ai bisogni emergenti del settore turistico. Le esperienze di visita mediate dal digitale mirano a coinvolgere i sensi e risultano efficaci quando promuovono immersioni rigorosamente realistiche. Nel quadro di queste riflessi…

New technologies have radically transformed not only geography as a discipline but also the geographies of the world. Indeed the digital has assumed an increasingly pervasive mediating role in the production of space as of geographic knowledge and imaginaries. The possibilities offered by the virtual in particular now offer a decisive contribution in communicating the meanings attributed to places and respond increasingly effectively to the emerging needs of the tourism sector. Digitally mediated visitor experiences aim to engage the senses and are effective when they promote rigorously realistic immersions. Within the framework of these reflections the paper highlights the renewed relevance of authenticity both of the tourism experience and of cultural heritage in relation to its potential for attraction and proposes a contextualization of the theme in light of the unprecedented opportunities granted by technologies for the creation of virtual and augmented spaces. The proposed discussion is therefore also a journey aimed at exploring authenticity as a tool through which new technologies can effectively mediate a sense of place and foster brand communication of a destination. The case study is the UNESCO site of Tarragona whose most relevant image for urban policies is presented. This shared figuration spatially defined and rooted in a precise historical moment is reconstructed on the one hand through the analysis of functional documentation for the candidacy and on the other by means of a review of mobile applications developed for the promotion of the city's cultural heritage. The proposed journey and exploration of the place return in light of the research data and in conclusion the central role played by digital technologies in mediating the UNESCO imaginary. The forms of virtual tourism in Tarragona confirm that to travel is to experience a text enveloped in time and inscribed in space.Settore M-GGR/01 - Geografia
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Morpho-sedimentary setting and evolution of Marettimo Valley (Egadi Islands, Sicily) during middle-late Quaternary: interaction between sea level cha…

2017

We present morphological and stratigraphic results coming from surveys acquired in a NNW-SSE trending submarine depression (Marettimo Valley) located in the Egadi Islands (western Sicily offshore). In this area the seafloor is characterized by both depositional and erosional features generated under a variety of sedimentary processes. We identified two seismic facies units that are correlatable to: A) the progradation of shallow water (coastal to offshore) deposits during forced-regression sedimentary process, and B) contourite drifts emplaced by geostrophic currents through the Marettimo Valley. This unusual association of very shallow water contourites and shelf margin deposits originates…

Ocean currentsLandformsSettore GEO/02 - Geologia Stratigrafica E SedimentologicaStratigraphyMechanical EngineeringSettore GEO/03 - Geologia StrutturaleDepositsSea levelAssociation reactionsElectrical and Electronic EngineeringInstrumentation
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Pro…

2017

Abstract Background The androgen receptor splice variant 7 (AR-V7) is associated with resistance to hormonal therapy in castration-resistant prostate cancer (CRPC). Due to limitations of the methods available for AR-V7 analysis, the identification of a reliable detection method may facilitate the use of this biomarker in clinical practice. Objective To confirm AR-V7 as a predictor of resistance to hormonal therapy and develop a new approach to assess AR-V7 by highly sensitive digital droplet polymerase chain reaction (ddPCR) in plasma-derived exosomal RNA. Design, setting, and participants Plasma samples were collected from 36 CRPC patients before they began second-line hormonal treatment. …

Oncology0301 basic medicineMaleResistanceExosomeschemistry.chemical_compoundProstate cancer0302 clinical medicineProtein IsoformsNeoplasm MetastasisReceptorAged 80 and overProstate cancerMiddle AgedProstatic Neoplasms Castration-ResistantReceptors Androgen030220 oncology & carcinogenesisBenzamidesAdenocarcinomaBiomarker (medicine)Hormonal therapyAR-V7; Digital droplet PCR; Exosomes; Hormonal therapy; Pharmacogenetics; Prostate cancer; Resistance; UrologyAndrostenesHormonal therapymedicine.medical_specialtyAntineoplastic Agents Hormonalmedicine.drug_classUrologyCastration resistantAdenocarcinomaDisease-Free Survival03 medical and health sciencesSDG 3 - Good Health and Well-beingInternal medicineNitrilesPhenylthiohydantoinmedicineEnzalutamideHumansAgedDigital droplet PCRPlasma derivedbusiness.industryRNAAndrogen Receptor Splice Variant 7medicine.diseaseAndrogenEndocrinology030104 developmental biologychemistryPharmacogeneticsDrug Resistance NeoplasmCancer cellCancer researchRNAAR-V7businessPharmacogenetics
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Germline loss-of-function variants in the BARD1 gene are associated with early-onset familial breast cancer but not ovarian cancer

2019

Background The role of the BARD1 gene in breast cancer (BC) and ovarian cancer (OC) predisposition remains elusive, as published case-control investigations have revealed controversial results. We aimed to assess the role of deleterious BARD1 germline variants in BC/OC predisposition in a sample of 4920 BRCA1/2-negative female BC/OC index patients of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC). Methods A total of 4469 female index patients with BC, 451 index patients with OC, and 2767 geographically matched female control individuals were screened for loss-of-function (LoF) mutations and potentially damaging rare missense variants in BARD1. All patients met the …

OncologyGermline0302 clinical medicineLoss of Function MutationSurgical oncologyOdds RatioPrevalenceMissense mutation030212 general & internal medicineAge of Onset10. No inequalityExomeEarly onset breast cancerAged 80 and overOvarian NeoplasmsBARD1 GeneHigh-Throughput Nucleotide SequencingMiddle Agedlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens3. Good health030220 oncology & carcinogenesisFemaleTechnology PlatformsResearch ArticleAdultmedicine.medical_specialtyAdolescentUbiquitin-Protein Ligases610Breast Neoplasmslcsh:RC254-282Young Adult03 medical and health sciencesGermline mutationBreast cancerOvarian cancerInternal medicinemedicineBARD1HumansGenetic Predisposition to DiseaseGermline mutationsGenetic Association StudiesGerm-Line MutationAgedbusiness.industryTumor Suppressor ProteinsOdds ratiomedicine.diseaseConfidence intervalBARD1; Early onset breast cancer; Germline mutations; Ovarian cancerOvarian cancerbusiness
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Evolution of coherent turbulent structures and relation with bed-forms formation in a straight flume

2008

The present paper describes some results of experimental work carried out in a rectilinear flume to investigate the interactions between flow turbulence and sediment motion. The analysis is conducted through the comparison between the periodicity of turbulent structures evolving along the channel and the wavelength of bed forms (alternate bars) forming on the bed. The occurrence of turbulent events (inward interaction, ejection, sweep and burst) has been verified through the conditioned quadrant analysis. The quantitative information about the spatial and temporal scale of the events has been obtained through the space-time correlations of the conditioned data. The analysis essentially high…

Open channel flow sediment transport bed-forms flow turbulence structureSettore ICAR/01 - Idraulica
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A survey on solvable sesquilinear forms

2018

The aim of this paper is to present a unified theory of many Kato type representation theorems in terms of solvable forms on a Hilbert space \((H,\langle\cdot,\cdot\rangle)\) In particular, for some sesquilinear forms Ω on a dense domain \(D\subseteq\mathcal {H}\) one looks for a representation \(\Omega(\xi,\eta)= \langle T\xi,\eta\rangle\) \((\xi\epsilon\mathcal{D}\mathcal(T),\eta\epsilon D)\) where T is a densely defined closed operator with domain \(D(\mathcal{T})\subseteq \mathcal{D}\). There are two characteristic aspects of a solvable form on H. One is that the domain of the form can be turned into a reexive Banach space that need not be a Hilbert space. The second one is that represe…

Operator (physics)Banach spaceHilbert spaceKato’s representation theoremType (model theory)Combinatoricssymbols.namesakeSettore MAT/05 - Analisi MatematicaProduct (mathematics)Bounded functionDomain (ring theory)symbolsQ-closed and solvable sesquilinear formsUnified field theoryMathematics
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