Search results for "Fostamatinib"

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Spleen Tyrosine Kinase (SYK) in the Progression of Peritoneal Fibrosis Through Activation of the TGF-β1/Smad3 Signaling Pathway.

2019

BACKGROUND Long-term exposure to hypertonic and high glucose in peritoneal dialysis fluid can result in peritoneal fibrosis. Spleen tyrosine kinase (SYK) has a role in inflammation and fibrosis. This study aimed to investigate the role of SYK in an in vivo rat model of peritoneal fibrosis and in rat peritoneal mesothelial cells (PMCs) in vitro and to investigate the underlying mechanisms. MATERIAL AND METHODS Sprague-Dawley rats (N=24) were randomized into the sham control group (N=6); the peritoneal fibrosis group (N=6) treated with intraperitoneal chlorhexidine digluconate; the SYK inhibitor group (N=6), treated with chlorhexidine digluconate and fostamatinib; and the TGF-s inhibitor grou…

ChinaSykInflammation030204 cardiovascular system & hematologyPharmacologyFostamatinibRats Sprague-DawleyTransforming Growth Factor beta103 medical and health sciences0302 clinical medicineWestern blotIn vivoFibrosismedicineAnimalsSyk KinaseSmad3 ProteinPeritoneal Fibrosismedicine.diagnostic_testChemistryAnimal StudyChlorhexidinePeritoneal FibrosisGeneral Medicinemedicine.diseaseRatsDisease Models AnimalNephrology030220 oncology & carcinogenesisDisease Progressionmedicine.symptomPeritoneumPeritoneal DialysisTransforming growth factormedicine.drugSignal TransductionMedical science monitor : international medical journal of experimental and clinical research

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