Search results for "Fracture"

Novel formulations of oral bisphosphonates in the treatment of osteoporosis

2022

AbstractOral bisphosphonates are a key intervention in the treatment of osteoporosis and in reducing the risk of fragility fractures. Their use is supported by over 3 decades of evidence; however, patient adherence to oral bisphosphonates remains poor in part due to complex dosing instructions and adverse events, including upper gastrointestinal symptoms. This problem has led to the development of novel oral bisphosphonate formulations. Buffered, effervescent alendronate is dissolved in water and so seeks to reduce upper gastro-intestinal adverse events, and gastro-resistant risedronate aims to reduce the complexity of dosing procedure (e.g. fasting prior to consumption) whilst still mainta…

Determination of the modulus of elasticity of bone material by an acoustical approach at the forearm distinguishes women with and without vertebral f…

2002

The modulus of elasticity is a parameter characterizing fracture stability of bone independent of bone mineral density. Measurement of acoustical properties of the forearm by determination of the resonant frequency of the ulna in longitudinal direction as a function of sound transmission velocity after adjustment of the measuring result by ulna length yields information about the modulus of elasticity. It was the aim of this study to investigate whether this parameter may distinguish between subjects with and without vertebral fractures independent of bone mineral density. Fifty females (61.1 +/- 9.1 years) were enrolled into the study, 25 with, and 25 age-matched without prevalent osteopor…

Erratum to: The burden of previuos fractures in hip fracture patients. The Break Study

2011

Does the association of therapeutic exercise and supplementation with sucrosomial magnesium improve posture and balance and prevent the risk of new f…

2021

Abstract Background Fracture of the proximal femur is the most feared complication of osteoporosis. Given the numerous physiological functions that magnesium performs in our body, in the literature there is a correlation between osteoporosis and low serum levels of magnesium. Aim Evaluate the incidence of hypomagnesemia in patients with lateral fragility fracture of the proximal femur, the possible correlation between serum magnesium levels and fractures, and the effectiveness of supplementing Sucrosomial® magnesium associated with therapeutic exercise on the outcome of these patients. Methods We divided the study into two parts. In the first part, we assessed the preoperative incidence of …

Endogenous Hormones, Muscle Strength, and Risk of Fall-Related Fractures in Older Women

2006

Background. Among older people, fracture-causing fall often leads to health deterioration. The role of endogenous hormone status and muscle strength on fall-related fracture risk is unclear. This study investigates if, after adjustment for bone density, endogenous hormones and muscle strength would predict fall-related limb fracture incidence in older community-dwelling women followed-up over 10 years. Methods. As a part of a prospective population-based study, 187 75-year-old women were investigated. Serum estradiol, testosterone, sex hormone binding globulin, and dehydroepiandrosterone sulfate concentrations were analyzed, and isometric muscle strength and bone mineral density were assess…

Combined resistance and balance-jumping exercise reduces older women's injurious falls and fractures: 5-year follow-up study

2014

BACKGROUND AND OBJECTIVE: previously, a randomised controlled exercise intervention study (RCT) showed that combined resistance and balance-jumping training (COMB) improved physical functioning and bone strength. The purpose of this follow-up study was to assess whether this exercise intervention had long-lasting effects in reducing injurious falls and fractures. DESIGN: five-year health-care register-based follow-up study after a 1-year, four-arm RCT. SETTING: community-dwelling older women in Finland. SUBJECTS: one hundred and forty-five of the original 149 RCT participants; women aged 70-78 years at the beginning. METHODS: participants' health-care visits were collected from computerised…

Estimation of the fatigue life of high strength steel under variable-amplitude tension with torsion: Use of the energy parameter in the critical plane

2003

Abstract The paper concerns application of the energy parameter, being a sum of the elastic and plastic strain energy density in the critical plane, for describing experimental data obtained in fatigue tests of 35NCD16 steel, subjected to constant amplitude tension-compression, torsion and variable amplitude tension-compression, torsion and combined proportional tension with torsion. It has been shown that the normal strain energy density in the critical plane is a suitable parameter for correlation of fatigue lives of 35NCD16 steel under considered kinds of loading. The critical plane is the plane where the normal strain energy density reaches its maximum value.

Hierarchical-ACA DBEM for Anisotropic Three-Dimensional Time-Harmonic Fracture Mechanics

2012

A hierarchical BEM solver for the analysis of three-dimensional anisotropic time-harmonic fracture mechanics problems is presented. A thorough investigation on the relations and interactions between the numerically computed anisotropic fundamental solutions and the algorithm used to approximate the blocks of the hierarchical matrix, namely Adaptive Cross Approximation, is carried out leading to the employed computational strategy. The use of the hierarchical matrices and iterative solvers is proved as an effective technique for speeding up the solution procedure and reducing the required memory storage in time-harmonic three-dimensional anisotropic fracture mechanics problems.

We are Still Learning from Death: After CPR, Balloon Expanding Valve (Intuity Aortic Valve) Revealed to be in Position

2021

Patients with high predicated risk undergo TAVI as an alternative treatment to surgical valve replacement...

Multidomain boundary integral formulation for piezoelectric materials fracture mechanics

2001

Abstract A boundary element method and its numerical implementation for the analysis of piezoelectric materials are presented with the aim to exploit their features in linear electroelastic fracture mechanics. The problem is formulated employing generalized displacements, that is displacements and electric potential, and generalized tractions, that is tractions and electric displacement. The generalized displacements boundary integral equation is obtained by using the closed form of the piezoelasticity fundamental solutions. These are derived through a displacement based modified Lekhnitskii’s functions approach. The multidomain boundary element technique is implemented to achieve the numer…