Search results for "Frame"
showing 10 items of 1767 documents
Exploring the catalytic performance of a series of bimetallic MIL-100(Fe, Ni) MOFs
2019
[EN] A series of mixed-metal Fe-III/Ni-II metal-organic frameworks (MOFs) of the MIL-100 type containing different metal ratios have been synthesized de novo, following an approach that requires tuning of the Fe-III/Ni-II reactivity. The resulting heterometallic MIL-100(Fe, Ni) materials maintain thermal, chemical and structural stability with respect to the parent MIL-100(Fe) MOF as can be deduced from various techniques. The nature and the oxidation state of the accessible metal cations have been evaluated by in situ infrared spectroscopy and extended X-ray absorption fine structure measurements. The obtained mixed-metal MOFs and the parent material have been evaluated as heterogeneous ca…
Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein.
2000
The DmX gene was recently isolated from the X chromosome of Drosophila melanogaster. TBLASTN searches of the dbEST databases revealed sequences with a high level of similarity to DmX in a variety of different species, including insects, nematodes, and mammals showing that DmX is an evolutionarily highly conserved gene. Here we describe the cloning of the cDNA and the chromosomal localization of one of the human homologues of DmX, Dmx-like 1 (DMXL1). The human DMXL1 gene codes for a large mRNA of 11 kb with an open reading frame of 3027 amino acids. The putative protein belongs to the superfamily of WD repeat proteins, which have mostly regulatory functions. The DMXL1 protein contains an exc…
Stimulation of protein (collagen) synthesis in sponge cells by a cardiac myotrophin‐related molecule from Suberites domuncula
2000
The body wall of sponges (Porifera), the lowest metazoan phylum, is formed by two epithelial cell layers of exopinacocytes and endopinacocytes, both of which are associated with collagen fibrils. Here we show that a myotrophin-like polypeptide from the sponge Suberites domuncula causes the expression of collagen in cells from the same sponge in vitro. The cDNA of the sponge myotrophin was isolated; the potential open reading frame of 360 nt encodes a 120 aa long protein (Mr of 12,837). The sequence SUBDOMYOL shares high similarity with the known metazoan myotrophin sequences. The expression of SUBDOMYOL is low in single cells but high after formation of primmorph aggregates as well as in in…
Performance-based research funding: Evidence from the largest natural experiment worldwide
2023
A performance-based research funding system (PRFS) is a nationwide incentive scheme that promotes and rewards university research performance through competition for government funding. The UK’s PRFS, currently the Research Excellence Framework (REF), is considered the oldest, largest and most developed payment-by-results system in academia worldwide. Surprisingly, and despite the strong criticisms, little has been done to quantitatively and casually evaluate the intended and unintended effects of the PRFSs. In this paper, we evaluate the incremental impact of the REF 2014 in the fields of Economics and Business. We use a synthetic control method to compare the performance of UK universitie…
Open Access & Research Assessment: Implementing OA for REF2021
2017
British Research Excellence Framework 2021 and it´s implications to deposit and access requirements of research publications.
Human Development from Middle Childhood to Middle Adulthood
2017
This seminal work focuses on human development from middle childhood to middle adulthood, through analysis of the research findings of the groundbreaking Jyvaskyla Longitudinal Study of Personality and Social Development (JYLS). The JYLS project, which began in 1968, has generated extensive publications over many years but this is the first comprehensive summary that presents the conceptual framework, the research design and methodology, and the findings. The study looks at the development over time of issues related to personality, identity, health, anti-social behavior, and well-being and is unparalleled in its duration, intensity, comprehensiveness and psychological richness. The thoroug…
Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: A European consensus position paper
2015
While they account for one-fifth of new cancer cases, rare cancers are difficult to study. A higher than average degree of uncertainty should be accommodated for clinical as well as for population-based decision making. Rules of rational decision making in conditions of uncertainty should be rigorously followed and would need widely informative clinical trials. In principle, any piece of new evidence would need to be exploited in rare cancers. Methodologies to explicitly weigh and combine all the available evidence should be refined, and the Bayesian logic can be instrumental to this end. Likewise, Bayesian-design trials may help optimize the low number of patients liable to be enrolled in …
Diagnoses as Selection Criteria in Drug Trials
1990
Drug trials are needed to establish the efficacy and safety of psychopharmacological agents in clearly defined indications. When the goal of treatment is more complex than removal of an isolated symptom (“difficulty in falling asleep” or “pain”) the syndrome or clinical entity to be treated is most easily classified by way of a diagnostic label (like “depression,” “schizophrenia,” or “panic disorder”). Dimensional models have many advantages: they often fit the data better and provide a conceptual framework for a continuum in the behavior from normal to abnormal. However, they have never reached the popularity of typological models (Strauss 1973, 1975, 1986) which reflect more the medical t…
Changes in group size during resource shifts reveal drivers of sociality across the tree of life
2020
ABSTRACTFrom biofilms to whale pods, organisms have repeatedly converged on sociality as a strategy to improve individual fitness. Yet, it remains challenging to identify the most important drivers—and by extension, the evolutionary mechanisms—of sociality for particular species. Here, we present a conceptual framework, literature review, and model demonstrating that the direction and magnitude of the response of group size to sudden resource shifts provides a strong indication of the underlying drivers of sociality. We catalog six functionally distinct mechanisms related to the acquisition of resources, and we model these mechanisms’ effects on the survival of individuals foraging in group…
Use and Identification of Components in Component-Based Software Development Methods
2000
New software systems are needed ever more but to keep up with this trend software developers must learn to create quality software more efficiently. One approach is to (re-)use components as building blocks of the new software. Recently there has been more interest to create component-based software development methods to support this. In this article we first set out requirements for reuse-based software development and then evaluate three component-based methods, namely Catalysis, OMT++, and Unified Process. As a conclusion we argue that evaluated methods produce prefabricated components and that component-based means that software developers can change better components to existing syste…