Search results for "Function"

Role of Oxidative Stress in Aging of the Retina in the ApoB100,LDLR-/- Mouse, a Murine Model of Aging of the Human Retina

2009

The human OR1G1 olfactory receptor is differentially activated by various sandalwood odorants. A joint approach combining in silico and in vitro expe…

2013

International audience; Sandalwood is a highly valuable component in perfumery. The action mode of sandalwood odorant molecules remains to be addressed. In fact, olfactory receptors involved in their perception have not yet been identified. The interaction of a human olfactory receptor, hOR1G1, with sandalwood odorants has been investigated. By means of cellular biology and functional tests experiments, we provide an additional insight to our atomic model of OR1G1 and our olfactophore approach performed on various odorants. The studied odorants cover a wide range of structures and sandalwood intensities. We experimentally show that beta-santalol is a strong agonist of hOR1G1, contrarily to …

Technological innovation around protein and cell biochip for diagnosis: a translational research from nanoworld to patient

2009

International audience; A great challenge in biosensors and diagnosis devices relies on the way to reconstitute relevant biological mechanisms on surface of the biochips and which analytical tools are convenient to provide accurate and rapid information on the structures and function of molecules attached to this surface. A better control in the realization of biochips can be obtained in combining different complementary approaches while always keeping in mind the biological key point. Researches in CLIPP are focused towards this objective. Conception, realization and characterization of protein and cell chips are presented. We detail different strategies of materials engineering1,2,3, chem…

X-linked primary ciliary dyskinesia due to mutations in the cytoplasmic axonemal dynein assembly factor PIH1D3

2017

International audience; By moving essential body fluids and molecules, motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the transport of gametes and cerebrospinal fluid. Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder frequently caused by non-assembly of dynein arm motors into cilia and flagella axonemes. Before their import into cilia and flagella, multi-subunit axonemal dynein arms are thought to be stabilized and pre-assembled in the cytoplasm through a DNAAF2DNAAF4- HSP90 complex akin to the HSP90 co-chaperone R2TP complex. Here, we demonstrate that large genomic deletions as well as point mutations involving PIH1D3 are…

Radiolabeling for long term biodistribution of ultrasmall nanoparticles designed for radiotherapy guided by MRI

2016

International audience

Improved Estimation of Cardiac Function Parameters Using a Combination of Independent Automated Segmentation Results in Cardiovascular Magnetic Reson…

2015

International audience; This work aimed at combining different segmentation approaches to produce a robust and accurate segmentation result. Three to five segmentation results of the left ventricle were combined using the STAPLE algorithm and the reliability of the resulting segmentation was evaluated in comparison with the result of each individual segmentation method. This comparison was performed using a supervised approach based on a reference method. Then, we used an unsupervised statistical evaluation, the extended Regression Without Truth (eRWT) that ranks different methods according to their accuracy in estimating a specific bio-marker in a population. The segmentation accuracy was …

Intérêt d'aménagements paysagers pour la biodiversité : exemple d'ingénierie agroécologique sur le domaine expérimental d'Epoisses (Inra Dijon)

2013

The biodiversity conservation is one of the major agricultural issues of the XXIst century. The intensification of agriculture and the redesign of the agricultural landscape (grouping of fields, …) lead to huge decreases or damages of semi-naturals habitats, known to promote biodiversity at the farm and the landscape scale, and now recognised as “topographic surface equivalence” in France.In the experimental site of Epoisses (INRA of Dijon), a study to design the landscape elements in favour of the biodiversity has been initiated. Improving the management of existing habitats (woods, hedges, ditches, sown grass margin strips), establishing hedges, flower strips, redesigning the field organi…

Soil aggregates and humus systems

2016

The European Society for Soil Conservation Conference, organized by the Babes-Bolyai University will take place from 15th June to the 18th June 2016 at the Babes-Bolyai University of Cluj-Napoca in Cluj-Napoca, Romania. The conference will cover areas like Soils – Our Common Future” stresses the vital interconnection between soil and life, as well as its importance for the future of the human society.; International audience; The survey of few main morphological soil aggregates (with intrinsic biological, chemical and physical contents) reveals the existence of different humus systems. Recognizable by naked eyes in the field, each humus system is confined in an ecological frame (climate, ve…

Analyse multi-échelles des compromis entre services écosystémiques fournis par la flore adventice

2021

Weeds contribute to the provision of various ecosystem services, negative when linked to their harmfulness (disservices) and positive due to the provision of trophic resources (floral resources, seeds) to pollinators and pest natural enemies (services). In this PhD thesis, we analysed how crop management strategies (coherent crop sequences and associated farming practices) implemented by farmers within a small agricultural landscape modulate the weed contribution to (dis)services provision. We also assessed the relative contribution of field cores and field edges (narrow area between the 1st row of the crop and the boundary) to these services. At the annual scale, we show that crop type hig…

Etude dynamique et structurale de biomolécules par microscopie à force atomique HS-AFM : application à une petite protéine de choc thermique sHsp

2012

The atomic force microscopy (AFM) gives access to the topography of organic and inorganic samplesat the atomic scale. The latest innovations offer the possiblity to understand the sample nano-mechanicalproperties (elasticity, adhesion...). Its feature set allows overcoming the demands of nanotechnology,both in the fields of physics, chemistry and biology.However, understanding biological processes require faster acquisitions for the atomic forcemicroscopy, less than a second per frame. As conventional equipment does not offer the possibility toovercome the constraint of time for dynamical studies, a prototype of high-speed atomic forcemicroscope (HS-AFM) was developed in partnership with Pr…