Search results for "Function"
showing 10 items of 14432 documents
Density functional/molecular dynamics simulations of phase-change materials
2013
Applying fully tensorial ICA to fMRI data
2016
There are two aspects in functional magnetic resonance imaging (fMRI) data that make them awkward to analyse with traditional multivariate methods - high order and high dimension. The first of these refers to the tensorial nature of observations as array-valued elements instead of vectors. Although this can be circumvented by vectorizing the array, doing so simultaneously loses all the structural information in the original observations. The second aspect refers to the high dimensionality along each dimension making the concept of dimension reduction a valuable tool in the processing of fMRI data. Different methods of tensor dimension reduction are currently gaining popUlarity in literature…
Development of Computerized Adaptive Testing for Emotion Regulation
2020
Emotion regulation (ER) plays a vital role in individuals’ well-being and successful functioning. In this study, we attempted to develop a computerized adaptive testing (CAT) to efficiently evaluate ER, namely the CAT-ER. The initial CAT-ER item bank comprised 154 items from six commonly used ER scales, which were completed by 887 participants recruited in China. We conducted unidimensionality testing, item response theory (IRT) model comparison and selection, and IRT item analysis including local independence, item fit, differential item functioning, and item discrimination. Sixty-three items with good psychometric properties were retained in the final CAT-ER. Then, two CAT simulation stud…
Semi-parametric estimation of conditional intensity functions in inhomogeneous space-time point processes
2009
Dealing with data coming from a space-time inhomogeneous process, there is often the need of obtaining estimates of the conditional intensity function, without a complete defi nition of a parametric model and so nonparametric estimation is required: isotropic or anisotropic kernel estimates can be used. The properties of the intensities estimated are not always good, expecially in seismological field. We could try to choose the bandwidth in order to have good predictive properties of the estimated intensity function. Since a direct ML approach can not be followed, we use an estimation procedure based on the further increments of likelihood obtained adding a new observation. Similarly to cro…
Conformational investigation of α,β‐dehydropeptides. XV: N‐acetyl‐α,β‐dehydroamino acid N ′N ′‐dimethylamides: conformational properties from infrare…
2005
The FTIR spectra were analysed in the region of the nu(s)(N-H), AI(C=O) and nu(s)(Calpha=Cbeta) bands for a series of Ac-DeltaXaa-NMe2, where DeltaXaa = DeltaAla, (Z)-DeltaAbu, (Z)-DeltaLeu, (Z)-DeltaPhe and DeltaVal, to determine a predominant solution conformation of these alpha,beta-dehydropeptide-related molecules. Measurements were taken in CCl4, DCM and MeCN solutions. In the same way, spectra of saturated analogues Ac-Xaa-NMe2, where Xaa = Ala, Abu, Leu, Phe and Val, were investigated. To help interpret the spectroscopic results, conformational maps were calculated by the B3LYP/6-31+G** method. Also, the relative energies of all conformers of the dehydro compounds in vacuo as well as…
Questions and controversies in the study of time-varying functional connectivity in resting fMRI.
2020
The brain is a complex, multiscale dynamical system composed of many interacting regions. Knowledge of the spatiotemporal organization of these interactions is critical for establishing a solid understanding of the brain’s functional architecture and the relationship between neural dynamics and cognition in health and disease. The possibility of studying these dynamics through careful analysis of neuroimaging data has catalyzed substantial interest in methods that estimate time-resolved fluctuations in functional connectivity (often referred to as “dynamic” or time-varying functional connectivity; TVFC). At the same time, debates have emerged regarding the application of TVFC analyses to re…
Impact of Fragile X Syndrome on Their Families
2020
espanolEl objetivo del presente estudio es describir las alteraciones conductuales y emocionales en el sindrome de X fragil (SXF) y analizar las reperecusiones de tener un miembro con SXF en diferentes aspectos del funcionamiento familiar. Participaron 79 padres con un miembro con SXF y 80 padres con un miembro con desarrollo tipico. Los resultados mostraron que entre el 17% y el 66% de los ninos y adolescentes con SXF mostraron trastornos conductuales y emocionales significativos y menos comportamientos prosociales. Ademas, despues de controlar las dificultades emocionales y de comportamiento, nuestros resultados mostraron que las familias afectadas por SXF experimentaron un impacto mas ne…
Current development of CFTR potentiators in the last decade
2020
Cystic fibrosis (CF) is a genetic disorder produced by the loss of function of CFTR, a main chloride channel involved in transepithelial salt and water transport. CFTR function can be rescued by small molecules called "potentiators" which increase gating activity of CFTR on epithelial surfaces. High throughput screening (HTS) assays allowed the identification of new chemical entities endowed with potentiator properties, further improved through medicinal chemistry optimization. In this review, the most relevant classes of CFTR potentiators developed in the last decade were explored, focusing on structure-activity relationships (SAR) of the different chemical entities, as a useful tool for t…
A Uniform Conspiracy Mindset or Differentiated Reactions to Specific Conspiracy Beliefs? Evidence From Latent Profile Analyses
2021
Conspiracy theories arise for virtually any public event (e.g., pandemics, assassinations, disasters). In light of positively correlated endorsements of such beliefs, many have pointed to a more general mindset behind this. Others have argued against this notion of a consistent mindset. Applying Latent Profile Analyses, we examine the evidence for either uniform or differentiated response patterns to various items in five studies (reanalyzed datasets, total N = 7877). Overall, the results speak strongly to uniform reactions that could be summarized as a general mindset, but also revealed important qualifications. First, small parts of the samples show more differentiated patterns in relatio…
Reproducing pairs of measurable functions
2017
We analyze the notion of reproducing pair of weakly measurable functions, which generalizes that of continuous frame. We show, in particular, that each reproducing pair generates two Hilbert spaces, conjugate dual to each other. Several examples, both discrete and continuous, are presented.