Search results for "Function"

Exploration of muscle–tendon biomechanics one year after Achilles tendon rupture and the compensatory role of flexor hallucis longus

2023

Achilles tendon (AT) rupture leads to long-term structural and functional impairments. Currently, the predictors of good recovery after rupture are poorly known. Thus, we aimed to explore the interconnections between structural, mechanical, and neuromuscular parameters and their associations with factors that could explain good recovery in patients with non-surgically treated AT rupture. A total of 35 patients with unilateral rupture (6 females) participated in this study. Muscle-tendon structural, mechanical, and neuromuscular parameters were measured 1-year after rupture. Interconnections between the inter-limb differences (Δ) were explored using partial correlations, followed by multivar…

Membrane Protein Complexes: Structure and Function

2018

This edited book contains a compilation of 14 advanced academic chapters dealing with the structure and function of membrane protein complexes. This rapidly advancing important field of study closely parallels those on soluble protein complexes, and viral protein and nucleoprotein complexes.Diverse topics are included in this book, ranging from membrane–bound enzymes to ion channels, proton pumps and photosystems. Data from X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are presented throughout the book. There is extensive use of colour figures of protein structures. Throughout the book structure and function are closely correlated.The two e…

Development and validation of an intrinsic capacity composite score in the Longitudinal Aging Study Amsterdam: a formative approach

2023

Abstract Background Intrinsic capacity (IC) defined by the WHO refers to the composite of five domains of capacities. So far, developing and validating a standardized overall score of the concept have been challenging partly because its conceptual framework has been unclear. We consider that a person’s IC is determined by its domain-specific indicators suggesting a formative measurement model. Aims To develop an IC score applying a formative approach and assess its validity. Methods The study sample (n = 1908) consisted of 57–88-year-old participants from the Longitudinal Aging Study Amsterdam (LASA). We used logistic regression models to select the indicators to the IC score with 6-year fu…

Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized cli…

2020

Background: Fibromyalgia (FM) is characterized by chronic pain and fatigue, among other manifestations, thus advising interventions that do not aggravate these symptoms. The main purpose of this study is to analyse the effect of low-pressure hyperbaric oxygen therapy (HBOT) on induced fatigue, pain, endurance and functional capacity, physical performance and cortical excitability when compared with a physical exercise program in women with FM. Methods: A total of 49 women with FM took part in this randomized controlled trial. They were randomly allocated to three groups: physical exercise group (PEG, n = 16), low-pressure hyperbaric oxygen therapy group (HBG, n = 17) and control group (CG, …

Family's role in long‐term care : A qualitative study of Finnish family members' experiences on supporting the functional ability of an older relative

2022

Family members are important providers of care for older people. In residential long-term care, however, their role is not always simple and straightforward: responsibility for care provision rests officially with staff members, but in practice family members often contribute to providing care. The main reason for admission to long-term care is functional decline. At the same time, the maintenance of functional ability is a central goal in long-term care. It is therefore reasonable to assume that functional ability is also an important factor in the relationship between family members and long-term care residents. This study aims to explore how family members experience their role in suppor…

"Semmonen siitä tuli Hitlerinki hommista" : ihmissuhteiden merkitykset skitsofreenistyyppisen psykoosin yhteydessä

2004

Local characteristics of functional marked point processes with applications to seismic data

2022

We present a family of local inhomogeneous mark-weighted summary statistics for general marked point processes. These capture various types of local dependence structures depending on the specified involved weight function. We use them to propose a local random labeling test. This procedure enables us to identify points and thus regions where the random labeling assumption does not hold, for example, when the (functional) marks are spatially dependent. We further present an application to a seismic point pattern with functional marks provided by seismic waveforms. Indeed, despite the relatively long history of point process theory, few approaches to analyzing spatial point patterns where th…

Functional principal component analysis of quantile curves

2017

Literature on functional data analysis is mainly focused on estimation of individuals curves and characterization of average dynamics. The idea underlying this proposal is to focus attention on other particular features of the distribution of the observed data, moving from mean functions towards functional quantiles. The motivating examples are functional data sets that are collections of high frequency data recorded along time. As quantiles provide information on various aspects of a time series, we propose a modelling framework for the joint estimation of functional quantiles, varying along time, and functional principal components, summarizing some common dynamics shared by the functiona…

Mushroom-Based Supplements in Italy: Let’s Open Pandora’s Box

2023

Mushrooms and derivates are well known to the scientific community for having different health benefits and exhibit a wide range of pharmacological activities, including lipid-lowering, antihypertensive, antidiabetic, antimicrobic, antiallergic, anti-inflammatory, anticancer, immunomodulating, neuroprotective and osteoprotective actions. In Europe, medical mushrooms are mainly marketed in the form of food supplements as single components or combined with other nutraceuticals. In this context, the first peculiarity that distinguishes it is the safety established through the “history of consumption” that characterizes that mushroom. However, the cultivation of medicinal mushrooms on a large s…

The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach

2022

For years it has been established that the only truly effective treatment of metabolic syndrome (MS) is lifestyle modification to prevent its cardiovascular (e.g., coronary artery disease and atherosclerosis), metabolic (e.g., diabetes mellitus), and hepatic (e.g., steatosis and non-alcoholic steatohepatitis) complications. The focal points of this approach are to increase physical activity and intake of a diet characterized by high quantities of fruits, vegetables, grains, fish, and low-fat dairy products, the so called mediterranean diet (MD); however, the added value of MD is the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids,…