Search results for "Function"

Subclinical Cardiotoxicity: The Emerging Role of Myocardial Work and Other Imaging Techniques.

2021

In recent years, the cancer survival of patients has improved thanks to advances in the pharmacological field. In many guidelines, cardiotoxicity induced by anticancer drugs was defined as a reduction from baseline in the left ventricular ejection fraction (LVEF) assessed by echocardiography. It is known that LVEF is not a sensible parameter in the detection of cardiotoxicity. Therefore, a decrease from baseline in the global longitudinal strain (GLS) or troponins elevation is used to detect subclinical cardiotoxicity. LVEF and GLS as well as the increase in some biomarkers are influenced by loading conditions that are frequent during chemotherapy. Other parameters not influenced by loading…

Brain event-related potentials (ERPs) measured at birth predict later language development in children with and without familial risk for dyslexia.

2005

We report associations between brain event-related potentials (ERPs) measured from newborns with and without familial risk for dyslexia and these same children's later language and verbal memory skills at 2.5, 3.5, and 5 years of age. ERPs to synthetic consonant-vowel syllables (/ba/, /da/, /ga/; presented equiprobably with 3,910-7,285 msec interstimulus intervals) were recorded from 26 newborns at risk for familial dyslexia and 23 control infants participating in the Jyvaskyla Longitudinal Study of Dyslexia. The correlation and regression analyses showed that the at-risk type of response pattern at birth (a slower shift in polarity from positivity to negativity in responses to /ga/ at 540-…

Sauerstoffversorgung trotz Atemstillstandes

1994

Respiratory Mechanics and Gas Exchange in Thoracic Surgery: Changes in Classical Knowledge in Respiratory Physiology

2020

Respiratory mechanics describe the lung function through pressure and flow and the interplay between the two during the respiratory cycle. Derived indices are volume, compliance and resistance (Hess, Respir Care 59(11):1773–1794, 2014). Thoracic surgery in most cases requires the separation of the lungs in order to allow surgery of or near one lung and ventilation of the other lung, while the perfusion to the non-ventilated lung is continued. This has profound implications for the gas exchange and respiratory mechanics.

The nephroprotective effect of sacubitril/valsartan in heart failure: insights from the real-life clinical setting

2019

Real-life data confirming the favourable renal outcome in patients with heart failure (HF) treated with Sacubitril/Valsartan, previously found in several trials (RCTs), are still scant. We evaluated the renal effects of Sacubitril/Valsartan in a real-life sample of HF patients. Observational analysis of 54 consecutive outpatients affected by HF with reduced ejection fraction (HFrEF) and clinical indication for Sacubitril/Valsartan. Patients were evaluated at baseline (T0) and after six (T6) and twelve (T12) months after initiating Sacubitril/Valsartan and compared with a group of 30 historical controls. Mean age: 65.5 ± 11.7 years. Older patients: 29 (53.7%). Mean baseline estimated glomeru…

Magnetic Resonance Assessment of Left Ventricular Ejection Fraction at Any Time Post-Infarction for Prediction of Subsequent Events in a Large Multic…

2021

Background Magnetic resonance imaging (MRI) is the most accurate imaging technique for left ventricular ejection fraction (LVEF) quantification, but as yet the prognostic value of LVEF assessment at any time after ST-segment elevation myocardial infarction (STEMI) for subsequent major adverse cardiac event (MACE) prediction is uncertain. Purpose To explore the prognostic impact of MRI-derived LVEF at any time post-STEMI to predict subsequent MACE (cardiovascular death or re-admission for acute heart failure). Study Type Prospective. Population One thousand thirteen STEMI patients were included in a multicenter registry. Field Strength/Sequence 1.5-T. Balanced steady-state free precession (c…

The treatment of severe self-injurious behavior through sensory stimulation: A case report

2016

Self-injurious behavior of an institutionalized man with profound intellectual disability was treated with a daily 15-min sensory stimulation program, which consisted of moving the arms and hands of the participant, swinging his body, and massage. The frequency of self-injurious behavior was measured in 10-min sessions. Using a reversal design, it was shown that sensory stimulation decreased the participant’s self-hitting behavior significantly, both in intensity and in frequency. Sensory stimulation is recommended for use in those cases in which functional analysis has shown that self-injury may be reinforced by its sensory consequences.

Influence of the tear film on optical quality of the eye

1997

The optical quality of the tear film of the eye was tested by measuring the retinal image before and after the break-up time (BUT). An objective method was used based on the evaluation of the retinal image of a point test projected onto the fovea. The loss of an entire tear film would result in a decrease in the optical quality because of corneal irregularities and the formation of an irregular tear lens after the BUT. Our results confirm the expected loss both of non-contact lens wearers and contact lens wearers. Also, the fact that the optical deterioration found after the BUT is greater for contact lens wearers confirms that soft contact lens wear produces a disruption of the tears.

Plasma derived protein C in severe sepsis: report of two cases

2008

Severe sepsis is defined as sepsis-associated organ dysfunction, (arterial hypoxemia, acute oliguria, coagulation abnormalities, thrombocytopenia, hyperbilirubinemia), hypoperfusion (hyperlactatemia) and arterial hypotension (mean arterial pressure \70 mmHg, or a systolic blood pressure decrease[40 mmHg) [3, 4]. Septic shock [3, 4] is defined as acute circulatory failure induced by sepsis with hypotension despite adequate fluid resuscitation. A dysfunction of the protein C (PC) pathway is always present in severe sepsis and contributes to the development of coagulopathy and necrosis [12, 13]. This decrease is caused by consumption of protein C during systemic activation of blood coagulation…

Sodium-glucose cotransporter 2 inhibition : towards an indication to treat diabetic kidney disease

2020

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have clearly demonstrated their beneficial effect in diabetic kidney disease (DKD) on top of the standard of care [blood glucose control, renin–angiotensin system blockade, smoking cessation and blood pressure (BP) control], even in patients with overt DKD. However, the indication of this drug class is still blood glucose lowering in type 2 diabetic patients with estimated glomerular filtration rate >45mL/min/1.73m2. Based on the new evidence, several scientific societies have emphasized the preferential prescription of SGLT2i for patients at risk of heart failure or kidney disease, but still within the limits set by health authorities. A r…