Search results for "Functions"

showing 10 items of 1066 documents

Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain

2009

Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expr…

Malemedicine.medical_specialtyTime FactorsCentral nervous systemHippocampusCell CountSettore BIO/11 - Biologia MolecolareBiologySettore BIO/09 - Fisiologiachemistry.chemical_compoundSeizuresInternal medicineSettore BIO/10 - BiochimicaCaSRmedicineAnimalsRNA MessengerRats WistarIbotenic AcidMolecular BiologyIn Situ HybridizationNeuronsKainic AcidGeneral NeuroscienceDentate gyrusBrainColocalizationImmunohistochemistryRatsOligodendrogliamedicine.anatomical_structureEndocrinologynervous systemchemistryBrain InjuriesNeurogliaNeurology (clinical)Pyramidal cellCaSR; BrainCalcium sensing receptor (CaSR) isolated for the first time from bovine and human parathyroid is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expression in neurons and oligodendrocytes whereas it was not found expressed both in the microglia and in astrocytes. One week after kainate-induced seizure CaSR was found in the injured CA3 region of the hippocampus and very interestingly it was found up-regulated in the neurons of CA1-CA2 and dentate gyrus. Similarly 1 week following ibotenic acid injection in the hippocampus CaSR mRNA expression was increased in oligodendrocytes both in the lesioned area and in the contralateral CA1-CA3 pyramidal cell layers and dentate gyrus. One week after needle-induced mechanical lesion an increase of labeled cells expressing CaSR mRNA was observed along the needle track. In conclusion the present results contribute to extend available data on cell type-expressing CaSR in normal and injured brain and could spur to understand the role of CaSR in repairing processes of brain injury.Receptors Calcium-SensingIbotenic acidDevelopmental BiologyAstrocyte
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Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial

2021

Gait speed is a measure of health and functioning. Physical and cognitive determinants of gait are amenable to interventions, but best practices remain unclear. We investigated the effects of a 12-month physical and cognitive training (PTCT) on gait speed, dual-task cost in gait speed, and executive functions (EFs) compared with physical training (PT) (ISRCTN52388040). Community-dwelling older adults, who did not meet physical activity recommendations, were recruited (n = 314). PT included supervised walking/balance (once weekly) and resistance/balance training (once weekly), home exercises (2-3 times weekly), and moderate aerobic activity 150 min/week in bouts of >10 min. PTCT included the…

Malemedicine.medical_specialtyTime FactorsComputer User TrainingWalk TestPhysical Therapy Sports Therapy and RehabilitationWalking030204 cardiovascular system & hematologylaw.inventionExecutive Function03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationRandomized controlled triallawHumansMedicineAerobic exerciseOrthopedics and Sports MedicinePostural BalanceAgedBalance (ability)Aged 80 and overTrail Making Testbusiness.industryResistance TrainingCognition030229 sport sciencesExecutive functionsGaitCognitive trainingExercise TherapyWalking SpeedStroop TestFemaleIndependent Livingbusinesshuman activitiesStroop effectScandinavian Journal of Medicine & Science in Sports
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Sexual dysfunction in dialytic patients. A prospective cross-sectional observational study in two hemodialysis centers

2020

Objectives: Incidence and prevalence of patients in dialytic therapy increased considerably in recent years. The onset of new issues, once overshadowed, linked to a lower quality of life like sexual dysfunction became increasingly common. The first study in this area, dating back to the 1970s, shows the high prevalence of sexual dysfunction among patients in dialytic therapy of both sexes. Later studies proved an association of sexual dysfunction with psyche disorders, anxiety, depression and lack of self-confidence. The aim of this study is to describe the incidence of male and female sexual main dysfunctions, the latter not least in literature, in patients in hemodialytic therapy. With th…

Malemedicine.medical_specialtyUrologymedia_common.quotation_subjectEnd-Stage Renal DiseasePopulation030232 urology & nephrologyErectile disorderOrgasmEnd stage renal disease03 medical and health sciences0302 clinical medicineErectile DysfunctionRenal DialysisSurveys and QuestionnairesInternal medicinePremature ejaculationmedicineHumansProspective StudiesFemale sexual dysfunctionseducationDialysis End-Stage Renal Disease Sexual male dysfunction Erectile disorder Premature ejaculation Female sexual dysfunctions International Index of Erectile Function Premature EjaculationAgedmedia_commoneducation.field_of_studyPremature ejaculation030219 obstetrics & reproductive medicinebusiness.industryIncidence (epidemiology)Middle Agedmedicine.diseaseSexual male dysfunctionDiseases of the genitourinary system. UrologyCross-Sectional StudiesSexual dysfunctionErectile dysfunctionQuality of LifeFemaleRC870-923medicine.symptombusinessDialysisKidney disease
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Differential diagnosis of behavioral variant of fronto-temporal dementia (bvFTD)

2011

Background: The aim of the paper is the differential diagnosis of various types of Fronto-Temporal Dementia (FTD), with the focus on its behavioural variant (bvFTD). Material/Method: Material and Method. Screening was done in order to assess the depth of dementia with the short version of MMSE, while evaluation of various variants of FTD was performed with the use of such neuropsychological tests as Newcomb and Chicago Fluency Tests, Wechsler Memory Scale - III (WMS-III), Western Aphasia Battery (WAB-R), and the Boston Naming Test (BNT). Behaviour was evaluated with a Polish version of the Frontal Behavioral Inventory (FBInv). The inventory consists of 24 questions which enable an evaluatio…

Malemedicine.medical_specialtyexecutive functions disordersgenetic structuresdisinhibitionFronto temporal dementiabehavioral disciplines and activitiesDiagnosis DifferentialCognitionClinical ResearchAlzheimer DiseaseMemorymental disordersmedicineHumansDementiafrontal cortex dysfunctionsPsychiatryAgedDemographyLanguageIntelligence TestsBehaviornutritional and metabolic diseasesCognitionGeneral Medicinemedicine.diseasenervous system diseasesimpairments of cognitive functionsFrontotemporal DementiaFemaleAlzheimer's diseaseDifferential diagnosisPsychologyNeuroscienceFrontotemporal dementiaMedical Science Monitor
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Improving Children's Coordinative Skills and Executive Functions

2016

Recent studies have focused on the positive influence of regular physical activity on executive functioning in children. Coordinative skills (agility) and executive functions (updating, attention, inhibition and planning processes) were investigated in children before and after 6 months of a Football Exercise Program compared to a control group of sedentary peers. The participants were 44 children aged 8.8 years: Group 1 comprised 24 children in a football (i.e., soccer) exercise program and Group 2 comprised 20 sedentary children. At pre-test and post-test, coordinative skills and executive functions were measured. After the Football Exercise Program, there were significant differences be…

Malemedicine.medical_specialtymotor skillExperimental and Cognitive PsychologyFootball050105 experimental psychologyDevelopmental psychologyagilityExecutive Function03 medical and health sciencesChild Development0302 clinical medicineExercise programAerobic exercise; Agility; Football exercise program; Motor skills; Planning; Soccer; Working memory; Medicine (all); Experimental and Cognitive Psychology; Sensory SystemsmedicineHumansAerobic exercise0501 psychology and cognitive sciencesCognitive skillChildExerciseMotor skillfootball exercise programWorking memoryMedicine (all)05 social sciencesWorking memoryExecutive functionssoccerSensory SystemsPlanningMemory Short-Termaerobic exerciseMotor Skillssoccer; aerobic exercise; motor skills; agility; working memory; planning; football exercise programSedentary groupPhysical therapyPsychology030217 neurology & neurosurgeryPerceptual and Motor Skills
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Longitudinal Associations of Fitness, Motor Competence, and Adiposity with Cognition

2019

Purpose: The purpose of this study was to investigate the longitudinal associations of cardiorespiratory fitness (CRF), motor competence (MC), and body fat percentage (BF%) with cognition in children. Methods: Altogether, 371 children (188 boys and 183 girls) 6–9 yr of age at baseline participated in this 2-yr follow-up study. We assessed CRF by maximal cycle ergometer test, computed the MC score from the z-scores of the 50-m shuttle run, static balance, and box and block test results, measured BF% by dual-energy x-ray absorptiometry, and assessed cognition using the Raven’s Coloured Progressive Matrices (RCPM) score. The associations were studied by linear regression analysis and repeated-…

Maleobesitycognitive functionsCHILDRENBody fat percentageCognition0302 clinical medicinenuoretOrthopedics and Sports MedicineCOGNITIVE FUNCTIONSLongitudinal Studiesta315Childta515FinlandAdiposityyouthylipainoCognitionta3142MOTOR SKILLSfyysinen kuntoCardiorespiratory FitnessYOUTHMotor SkillsOBESITYFemaleCARDIORESPIRATORY FITNESSkognitiiviset taidotMulti-stage fitness testmedicine.medical_specialtyPhysical Therapy Sports Therapy and Rehabilitation03 medical and health sciencesRaven's Progressive MatriceschildrenInternal medicineLinear regressionmedicineHumansmotoriset taidotlapsetbusiness.industryCardiorespiratory fitness030229 sport sciencesmedicine.diseaseObesityConfidence intervallihavuusnuoruusbusinessFollow-Up Studies
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Physical activity, aerobic fitness, and brain white matter : Their role for executive functions in adolescence

2020

Highlights • Aerobic fitness level, but not physical activity, is related to white matter properties in the brain. • The relation between physical activity and working memory is moderated by fractional anisotropy (FA) of the corpus callosum. • The FA of the corpus callosum and superior corona radiata moderates the relation between aerobic fitness and working memory.

Malephysical activitySpatial memoryDevelopmental psychologyExecutive functionsExecutive Function0302 clinical medicinenuoretCOGNITIVE CONTROLDWI diffusion-weighted imagingFitnessdiffuusiotensorikuvaus315 Sport and fitness sciencesPLASTICITYFA fractional anisotropyChildOriginal ResearchTBSS Tract-Based Spatial Statisticslcsh:QP351-495White matterCognitionExecutive functionsdiffusion tensor imagingexecutive functionsmurrosikäRD radial diffusivityINTEGRITYfitnessfyysinen kuntomedicine.anatomical_structureDiffusion tensor imagingFemalePsychologyaivotRVP rapid visual information processingwhite matterNeurovetenskaperAD axial diffusivityfractional anisotropyfyysinen aktiivisuusMulti-stage fitness testendocrine systemtoiminnanohjaus (psykologia)AdolescentDISTORTION CORRECTIONMVPA moderate-to-vigorous intensity physical activityPhysical activityTFCE threshold-free cluster enhancementWhite matter03 medical and health sciencesWORKING-MEMORY030225 pediatricsmedicineAerobic exerciseHumansExerciseAgedOBJECTIVE MEASURESMD mean diffusivityWorking memoryPhysical activityNeurosciencesPUBERTAL CHANGESvalkea aineCORPUS-CALLOSUMlcsh:Neurophysiology and neuropsychologySWM patial working memoryVOLUMEMICROSTRUCTURECANTAB Cambridge Neuropsychological Automated Test BatteryMRI magnetic resonance imaging030217 neurology & neurosurgeryFractional anisotropy
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Male infertility: an obstacle to sexuality?

2016

International audience; Interactions between infertility and sexuality are numerous and complex. Infertile men may suffer from sexual dysfunction (SD) when undergoing an assisted reproductive technology programme. We undertook a review both in French and English of the available data on male SD when being diagnosed with a fertility problem with a specific focus on azoospermic men. The review was performed over a 30-year time period using PubMed/Medline. The sexual concerns and needs of infertile/sterile men for whom potential parenting can be compromised were evaluated. When diagnosed with infertility, men usually go through a crisis that can have a deleterious effect on their sexuality wit…

Malereproductive technologiesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentSocial Stigma030232 urology & nephrologyHuman sexualityReproductive technologymale infertilityMale infertility0302 clinical medicineEndocrinologypsychological distressSexual Dysfunctions Psychologicaldisorders[ SDV.MHEP.GEO ] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetricsklinefelters-syndromemedia_commonReproductive health030219 obstetrics & reproductive medicineazoospermia3. Good healthsexual dysfunctionimpactcouple infertilitymedicine.symptomClinical psychologyInfertilitymedicine.medical_specialtyerectile dysfunctionSexual BehaviorUrologymedia_common.quotation_subjectsexual healthmenFertility[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics03 medical and health sciencesivfmedicineHumansInfertility MaleGynecologyAssisted reproductive technologybusiness.industrymedicine.diseaseSexual dysfunctionReproductive Medicinequality-of-lifebusinessAndrology
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The heritability of depressive symptoms: multiple informants and multiple measures

2002

Background: Earlier research suggests large rater differences in heritability estimates of children's depressive symptoms in the context of significant age and sex-limitation effects. Methods: With data from an ongoing, population-based twin-family study, we estimated genetic and environmental influences on children's depression with models allowing for sex-specific effects. Our assessments of twins included self-reports and ratings made by their classmate peers, their parents and their teachers, allowing estimates of genetic and environmental effects with data from different informants. Model-fitting used maximum likelihood estimation of log-transformed data from a sample of 1,366 11- and …

Malesex differencesMultivariate analysisCHILDHOODCHILDRENDevelopmental psychology0302 clinical medicineTwins DizygoticDevelopmental and Educational PsychologyANXIETYAdditive genetic effectsLongitudinal StudiesChildFinlandLikelihood Functionseducation.field_of_study05 social sciencesPSYCHOPATHOLOGYtwinsPsychiatry and Mental healthmultivariate analysisADOLESCENCEdepressionAnxietyFemalemedicine.symptomPsychologyBEHAVIOR050104 developmental & child psychologyPsychopathologyDISORDERSeducationPopulationTWINContext (language use)03 medical and health sciencesSex FactorsAGEGENETIC-ANALYSISDiseases in TwinsmedicineHumansGenetic Predisposition to Disease0501 psychology and cognitive scienceseducationModels GeneticSocial environmentTwins MonozygoticHeritabilityPediatrics Perinatology and Child Health030217 neurology & neurosurgeryJournal of Child Psychology and Psychiatry
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Weighted Least-Squares Likelihood Ratio Test for Branch Testing in Phylogenies Reconstructed from Distance Measures

2005

A variety of analytical methods is available for branch testing in distance-based phylogenies. However, these methods are rarely used, possibly because the estimation of some of their statistics, especially the covariances, is not always feasible. We show that these difficulties can be overcome if some simplifying assumptions are made, namely distance independence. The weighted least-squares likelihood ratio test (WLS-LRT) we propose is easy to perform, using only the distances and some of their associated variances. If no variances are known, the use of the Felsenstein F-test, also based on weighted least squares, is discussed. Using simulated data and a data set of 43 mammalian mitochondr…

MammalsLikelihood FunctionsModels GeneticReproducibility of ResultsGeneralized least squaresClassificationDNA MitochondrialDistance measuresEvolution MolecularData setData Interpretation StatisticalLikelihood-ratio testStatisticsHIV-1GeneticsAnimalsCluster AnalysisPoint (geometry)PhylogenyEcology Evolution Behavior and SystematicsIndependence (probability theory)Reliability (statistics)Selection (genetic algorithm)MathematicsSystematic Biology
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