Search results for "Furt"
showing 10 items of 84 documents
La importancia de lo que amamos: autorrealización y normatividad práctica en la obra de Harry G. Frankfurt
2015
La tesis pretende reconstruir críticamente la reflexión realizada por el filósofo estadounidense Harry G. Frankfurt a partir de los años 1960 sobre las fuentes de la normatividad práctica de los agentes humanos. No es descabellado caracterizar los múltiples caminos que ha recorrido la obra de Frankfurt desde sus comienzos como el cauce horadado en su incesante búsqueda de dar una respuesta a la pregunta: “¿qué es ser una persona?”. Los senderos seguidos, así como los trazados, permiten ubicar a Frankfurt como promotor o comentarista destacado en las discusiones filosóficas más relevantes sobre la libertad de la voluntad, la responsabilidad moral, la normatividad práctica, la teoría de la ac…
Identification In Silico and In Vitro of Novel Trypanosomicidal Drug-Like Compounds
2012
Atom-based bilinear indices and linear discriminant analysis are used to discover novel trypanosomicidal compounds. The obtained linear discriminant analysis-based quantitative structure–activity relationship models, using non-stochastic and stochastic indices, provide accuracies of 89.02% (85.11%) and 89.60% (88.30%) of the chemicals in the training (test) sets, respectively. Later, both models were applied to the virtual screening of 18 in-house synthesized compounds to find new pro-lead antitrypanosomal agents. The in vitro antitrypanosomal activity of this set against epimastigote forms of Trypanosoma cruzi is assayed. Predictions agree with experimental results to a great extent (16/18…
On the Very Idea of a Robust Alternative
2011
According to the Principle of Alternative Possibilities (PAP), an agent is morally responsible for an action of hers only if she could have done otherwise. The notion of a robust alternative plays a prominent role in recent attacks on PAP based on so-called Frankfurt cases. In this paper I defend the truth of PAP for blameworthy actions against Frankfurt cases recently proposed by Derk Pereboom and David Widerker. My defence rests on some intuitively plausible principles that yield a new understanding of the concept of a robust alternative. I will leave aside whether PAP also holds for praiseworthy actions.
Doing One’s Best, Alternative Possibilities, and Blameworthiness
2014
En este trabajo me propongo principalmente mejorar y dar un apoyo mas firme a una defensa del Principio de Posibilidades Alternativas (PPA) frente a los casos Frankfurt que propuse en trabajos anteriores. En el presente articulo concentro mi atencion en un reciente y famoso caso Frankfurt, �Evasion de impuestos�, disenado por Derk Pereboom. Tras presentar los aspectos esenciales de mi defensa del PPA y aplicarlos al caso de Pereboom, considero distintas objeciones que han sido (o podrian ser) planteadas a dicha defensa y sostengo que no tienen exito. Concluyo senalando que mi critica al ejemplo de Pereboom sugiere una estrategia general contra otros casos Frankfurt, tanto posibles como efec…
Aikalaiskritiikin mahdollisuus: Etiikka ja estetiikka Theodor W. Adornon kulttuurifilosofiassa
2015
Ajankohtaisten kulttuuristen ja yhteiskunnallisten teemojen käsittely sekä läheinen suhde estetiikkaan ovat olennainen osa mannermaiseksi kutsuttua filosofian perinnettä. Nämä teemat risteävät modernismissa, joka muodostaa monialaisen ongelmakentän aikalaiskriittiselle kulttuurifilosofialle. Tässä artikkelissa tarkastellaan, miltä modernismin filosofia näyttää saksalaisen idealismin perinteeseen nojaavan Theodor W. Adornon ajattelun valossa. peerReviewed
La Universidad Menéndez Pelayo rinde homenaje a José Vidal-Beneyto
2010
The cytosolic Arabidopsis thaliana cysteine desulfurase ABA3 delivers sulfur to the sulfurtransferase STR18
2020
ABSTRACTThe biosynthesis of many sulfur-containing molecules depends on cysteine as a sulfur source. Cysteine desulfurase (CD) and rhodanese (Rhd) domain-containing protein families participate in the trafficking of sulfur for various metabolic pathways in bacteria and human, but their connection is not yet described in plants. The existence of natural chimeric proteins, however, containing both CD and Rhd domains in specific bacterial genera suggests a general interaction between both proteins. We report here the biochemical relationships between two cytosolic proteins from Arabidopsis thaliana, a Rhd domain containing protein, the sulfurtransferase 18 (STR18), and a CD isoform referred to…
Urmylation and tRNA thiolation functions of ubiquitin-like Uba4·Urm1 systems are conserved from yeast to man
2015
AbstractThe ubiquitin-like protein Urm1 from budding yeast and its E1-like activator Uba4 have dual roles in protein urmylation and tRNA thiolation pathways. To study whether these are conserved among eukaryotes, we used gene shuffles to replace the yeast proteins by their human counterparts, hURM1 and hUBA4/MOCS3. As judged from biochemical and genetical assays, hURM1 and hUBA4 are functional in yeast, albeit at reduced efficiencies. They mediate urmylation of the peroxiredoxin Ahp1, a known urmylation target in yeast, and support tRNA thiolation. Similar to hUBA4, yeast Uba4 itself is modified by Urm1 and hURM1 suggesting target overlap between eukaryal urmylation pathways. In sum, our st…
FORMATION OF TEACHERS’ COMPETENCES IN FURTHER EDUCATION
2019
The interest of contemporary society in improving the quality of education is mainly reflected in the issue of educational results - competences - and their provision in the learning process. Introducing the 21st Century educational standards, the development of competencies required for teaching become more relevant. International documents indicate that a teacher should have the ability to teach, effectively use technologies in learning, help students gain transversal competencies. The teacher should be able to participate in research, use innovation, reflect on his/her work, collaborate with colleagues and parents. It is the teacher’s duty to direct the student's individual development.…