Search results for "G.1.0"
showing 10 items of 111 documents
Vesiclepedia:A Compendium for Extracellular Vesicles with Continuous Community Annotation
2012
Vesiclepedia is a community-annotated compendium of molecular data on extracellular vesicles.
Discharges of past flood events based on historical river profiles
2008
Abstract. This paper presents a case study on the estimation of peak discharges of extreme flood events during the 19th century of the Neckar River located in south-western Germany. It was carried out as part of the BMBF (German Federal Ministry of Education and Research) research project RIMAX (Risk Management of Extreme Flood Events). The discharge estimations were made for the 1824 and 1882 flood events, and are based on historical cross profiles. The 1-D model Hydrologic Engineering Centers River Analysis System (HEC-RAS) was applied with different roughness coefficients to determine these estimations. The results are compared (i) with contemporary historical calculations for the 1824 a…
A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refract…
2018
ABSTRACT We assessed the tolerability and antitumor activity of solitomab, a bispecific T-cell engager (BiTE®) antibody construct targeting epithelial cell adhesion molecule (EpCAM). Patients with relapsed/refractory solid tumors not amenable to standard therapy received solitomab as continuous IV infusion in a phase 1 dose-escalation study with six different dosing schedules. The primary endpoint was frequency and severity of adverse events (AEs). Secondary endpoints included pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity. Sixty-five patients received solitomab at doses between 1 and 96 µg/day for ≥28 days. Fifteen patients had dose-limiting toxicities (DLTs): e…
High-resolution orthophoto map and digital surface models of the largest Argentine Islands (the Antarctic) from unmanned aerial vehicle photogrammetry
2020
This study presents the first high-resolution orthophoto maps and digital surface models (DSMs) of the largest Argentine Islands, West Antarctica. Aerial surveys with small unmanned aerial vehicle (UAV) were performed in Austral summer, 2018, taking 10,041 aerial photographs. Accuracy requirements were ensured using ground control points (GCPs). A resolution of 3.4 and 6.8 cm/px of orthomosaics and DSMs is reached on average, and the RMS reprojection error is 0.22 m on average. We report the morphometric parameters of surveyed islands and discuss issues related to accuracy and the usage of UAVs in polar conditions. This study demonstrates that small and low cost UAVs can be successfully use…
Geomorphology and surface geology of Mount St. Helens volcano
2020
Mount St. Helens is a stratovolcano of the Cascadia volcanic arc well known worldwide for its volcanic collapse and eruption in 1980, which caused considerable destruction and changed the geomorphology of the volcano and of a considerable portion of its surroundings. This paper presents a geomorphology and surface-geology map of both the wider Mount St. Helens, Washington (USA), at the 1:50,000 scale, and of its crater, at the 1:25,000 scale. The map is obtained from the interpretation of two high-resolution, air-borne acquired, digital terrain models, LiDAR dataset, combined with Google Earth imaging, geological information and field surveys. The geomorphology of the area is largely domina…
Geomorphology of the urban area of Palermo (Italy)
2020
The results of a geomorphological study carried out in the urban area of Palermo are summarized in a thematic map. Field survey, analysis of aerial photographs and topographic maps, consultation of historical documents and maps, stratigraphic and topographic reconstruction from numerous wells and subsoil data, and bibliographic search were performed, in order to display the geomorphological changes produced by man over time in a densely populated area and to define the Anthropocene of the study area. Palermo town rises along large marine terrace surfaces cut by small river valleys and bordered by wide degraded and abandoned coastal cliffs. Over the last 2700 years, this area was affected by…
We are the people and you are fake news: a social identity approach to populist citizens’ false consensus and hostile media perceptions
2018
This study aims to investigate the relationships between citizens’ populist attitudes, perceptions of public opinion, and perceptions of mainstream news media. Relying on social identity theory as an explanatory framework, this article argues that populist citizens assume that public opinion is congruent with their own opinion and that mainstream media reporting is hostile toward their own views. To date, only anecdotal evidence suggests that both assumptions are true. The relationships are investigated in a cross-sectional survey with samples drawn from four Western European countries ( N = 3,354). Multigroup regression analysis supports our hypotheses: False consensus and hostile media p…
Screening for inhibitors of HIV gp120-CD4 binding using an enzyme-linked immunoabsorbent assay.
1993
Binding of the HIV-1 major viral surface glycoprotein, gp120, to the major cell receptor, CD4, is essential for HIV infection of the target cell and syncytium formation. An enzyme-linked immunoassay using solid phase CD4 was used to quantitate the binding of HIV-1 gp120 to CD4, and to assess the activity and mechanism of action of putative inhibitors of that reaction. Monoclonal antibodies to the gp120 binding site on CD4 (e.g., Leu3a) blocked gp120 binding, while monoclonal antibodies to other portions of CD4 (e.g. OKT4) did not. Both aurintricarboxylic acid and sulfonated polysaccharides (e.g., dextran sulfate) blocked CD4-gp120 interactions by binding to the CD4 component. Human polyclon…
Failure mode and effects analysis of skin electronic brachytherapy using Esteya® unit
2016
Purpose: Esteya® (Nucletron, an Elekta company, Elekta AB, Stockholm, Sweden) is an electronic brachytherapy device used for skin cancer lesion treatment. In order to establish an adequate level of quality of treatment, a risk analysis of the Esteya treatment process has been done, following the methodology proposed by the TG-100 guidelines of the American Association of Physicists in Medicine (AAPM). Material and methods: A multidisciplinary team familiar with the treatment process was formed. This team developed a process map (PM) outlining the stages, through which a patient passed when subjected to the Esteya treatment. They identified potential failure modes (FM) and each individual FM…
A review of acute aerobic exercise and transcranial direct current stimulation effects on cognitive functions and their potential synergies
2018
Today, several pharmaceutic and non-pharmaceutic approaches exist to treat psychiatric and neurological diseases. Because of the lack of treatment procedures that are medication free and without severe side effects, transcranial direct current stimulation (tDCS) and aerobic exercise (AE) have been tested to explore the potential for initiating and modulating neuroplasticity in the human brain. Both tDCS and AE could support cognition and behavior in the clinical and non-clinical context to improve the recovery process within neurological or psychiatric conditions or to increase performance. As these techniques still lack meaningful effects, although they provide multiple beneficial opportun…