Search results for "G1"
showing 10 items of 717 documents
Corrigendum to “Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans” [J. Neuroim…
2007
Transcriptomic autophagy-related gene signature investigation for type 2 diabetes in Mediterranean subjects
2021
Abstract Background Autophagy (involving degradation and clearance of damaged organelles and compounds) plays a role in type 2 diabetes (T2D). There are three main types of autophagy and several genes involved. These genes have been well studied in animal models, but there are few transcriptomic studies in humans. Our aim is to analyze the differential gene expression, and the functional enrichment of the main autophagy-related genes (ARG) in T2D subjects from a Mediterranean population Methods We analyzed 120 White-European subjects (mean age 61,4 years; 50% women; 24 T2D) from Valencia, Spain. Clinical and lifestyle data were obtained. ARN was isolated from blood. Transcriptome-wide gene …
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells
2012
Abstract Background Aneuploidy has been acknowledged as a major source of genomic instability in cancer, and it is often considered the result of chromosome segregation errors including those caused by defects in genes controlling the mitotic spindle assembly, centrosome duplication and cell-cycle checkpoints. Aneuploidy and chromosomal instability has been also correlated with epigenetic alteration, however the molecular basis of this correlation is poorly understood. Results To address the functional connection existing between epigenetic changes and aneuploidy, we used RNA-interference to silence the DNMT1 gene, encoding for a highly conserved member of the DNA methyl-transferases. DNMT1…
Construction of a webgis tool based on a gis semiautomated processing for the localization of p2g plants in sicily (Italy)
2021
The recent diffusion of RES (Renewable Energy Sources), considering the electric energy produced by photovoltaic and wind plants, brought to light the problem of the unpredictable nature of wind and solar energy. P2G (Power to Gas) implementation seems to be the right solution, transforming curtailed energy in hydrogen. The choice of the settlement of P2G plants is linked to many factors like the distances between the gas grid and the settlement of RES plants, the transportation networks, the energy production, and population distribution. In light of this, the implementation of a Multi-Criteria Analysis (MCA) into a Geographic Information System (GIS) processing represents a good strategy …
Análisis y tipología de brechas viarias dentro del palimpsesto urbano de València
2020
espanolEl palimpsesto urbano es el resultado de la superposicion y yuxtaposicion diacronica de una serie de modelos de desarrollo urbano que han determinado, en mayor o menor medida, la trama viaria actual. Resultado de esta dinamica, la trama urbana de muchas ciudades presenta una serie de brechas viarias singulares –por sus formas sinuosas, transversales u oblicuas– que dan caracter e identidad al paisaje urbano. En este articulo se analizan –mediante SIG y revision bibliografica– las brechas viarias del palimpsesto urbano, tomando como paradigma el plano de la ciudad de Valencia. Se lleva a cabo tambien una original categorizacion de las brechas viarias de acuerdo a una taxonomia derivad…
Representaciones escolares del Clima en el Paisaje fluvial del río Clariano
2020
Resumen:El conocimiento de la relación entre el clima y el paisaje convive con las dificultades propias del ámbito escolar. Para saber qué ocurre en su enseñanza, se analiza por medio del instrumento Evocation 2005 y los registros pictóricos, las representaciones sociales que tiene una parte del alumnado de 1º ESO. El estudio de caso sobre un paisaje fluvial en un ámbito local confirma la idealización del paisaje y la escasa presencia del clima en las representaciones del alumnado, esto junto con las dificultades de los docentes en su conocimiento disciplinar y su práctica nos conmina a quebrar las tradiciones y rutinas escolares para afrontar mejor las explicaciones de las transformaciones…
Cultura, innovación y desarrollo local
2002
Juan.M.Albertos@uv.es La Geografía Económica se enfrenta a la necesidad de integrar en sus planteamientos un «giro cultural» sin que ello suponga un debilitamiento de sus bases teóricas y de su potencial como disciplina aplicada. El presente artículo plantea una posible vía de integración de los factores culturales, considerando su papel en los procesos de innovación y en el desarrollo local. Para ello se trata el papel de la cultural local en la generación de relaciones de confianza o en la transmisión de información y conocimiento; asimismo se analiza específicamente el papel de la cultura técnica y de la cultura empresarial como componentes cualificados de la cultura local. Economic Geog…
Estudio sedimentológico de los depósitos de inundación en la Ribera del Xúqer (Valencia), en octubre de1982
2013
As a result of the sedimentological study of a series of deposits corresponding to the exceptional flood in the Xuquer River in October 1982, we analyze the behaviour of fluvial dynamics. The sedimentary response enables us lo perceive certain differences between the deposits analyzed, bUI these do not completely adjust to the genetic patterns considered in the classic Geomorphology as the producers ofthe traits ofvertical growth generated during floods.
Flash-flooding of Ephemeral Streams in the Context of Climate Change
2021
Ephemeral streams, which are more extended than expected, entail a significant flood risk. Historically they have been underestimated due to their intermittent flow and the lack of knowledge on their hydro-geomorphology. Currently, European legislation recognizes their associated risk and supports research into them, adapting the scale and methodology to their characteristics. Based on the compilation of various works carried out in four Valencian catchments (Eastern Spain), this paper approaches the key questions of rainfall-runoff conversion and flood generation in ephemeral streams, taking into account their hydro-geomorphological specificity. Moreover, the consequences which derive from…
Le due Algeri di Pontecorvo: spazi sociali nella lotta all’indipendenza
2021
Nel breve saggio si riflette sul ruolo del cinema come mezzo capace di mostrare lo spazio come luogo di lotta politica. Attraverso l’ascolto e la narrazione degli “attori” locali, nell’elaborazione dei loro pensieri, si è costruito il film ma anche una metodologia della ricerca. Pontecorvo affronta il tema della violenza mostrandone tutti i lati oscuri, ne ricostruisce l’escalation senza dimenticare che il centro della storia è la resistenza anticoloniale. Su queste basi, il saggio, mostra come lo spazio di Algeri sia frammentato in due (colonizzatori e colonizzati) e come la lotta sfrutti le caratteristiche topologiche della città