Search results for "G1"
showing 10 items of 717 documents
Three-dimensional structure of the anaphase-promoting complex.
2001
The anaphase-promoting complex (APC) is a cell cycle-regulated ubiquitin-protein ligase, composed of at least 11 subunits, that controls progression through mitosis and G1. Using cryo-electron microscopy and angular reconstitution, we have obtained a three-dimensional model of the human APC at a resolution of 24 A. The APC has a complex asymmetric structure 140 A x 140 A x 135 A in size, in which an outer protein wall surrounds a large inner cavity. We discuss the possibility that this cavity represents a reaction chamber in which ubiquitination reactions take place, analogous to the inner cavities formed by other protein machines such as the 26S proteasome and chaperone complexes. This cag…
The Abundant Tegument Protein pUL25 of Human Cytomegalovirus Prevents Proteasomal Degradation of pUL26 and Supports Its Suppression of ISGylation
2018
The tegument of human cytomegalovirus (HCMV) virions contains proteins that interfere with both the intrinsic and the innate immunity. One protein with a thus far unknown function is pUL25. The deletion of pUL25 in a viral mutant (Towne-ΔUL25) had no impact on the release of virions and subviral dense bodies or on virion morphogenesis. Proteomic analyses showed few alterations in the overall protein composition of extracellular particles. A surprising result, however, was the almost complete absence of pUL26 in virions and dense bodies of Towne-ΔUL25 and a reduction of the large isoform pUL26-p27 in mutant virus-infected cells. pUL26 had been shown to inhibit protein conjugation with the in…
Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantati…
2022
Abstract Background Successful implantation is dependent on coordination between maternal endometrium and embryo, and the role of EVs in the required cross-talk cell-to-cell has been recently established. In this regard, it has been reported that EVs secreted by the maternal endometrium can be internalized by human trophoblastic cells transferring their contents and enhancing their adhesive and invasive capacity. This is the first study to comprehensively evaluate three EV isolation methods on human endometrial epithelial cells in culture and to describe the proteomic content of EVs secreted by pHEECs from fertile women. Methods Ishikawa cells and pHEECs were in vitro cultured and hormonall…
A diversity of patterns: 10-year trajectories of men and women diagnosed with psychosis for the first time. A time-geographic approach
2020
People with severe mental illness face a different interventional landscape compared to some decades ago, when mental hospitals were dominant, in Sweden as well as in the rest of the Western world. The aim of the research reported in this article was to follow men and women diagnosed with psychosis for the first time over a 10-year period, and to explore what interventions they experienced. The interventions, here defined as "spheres", were either community-based or institutional. A third sphere represents no interventions. Based on data from registers and using a time-geographic approach, the individuals were visualised as 10-year trajectories where their transitions between the different …
Finitely fibered Rosenthal compacta and trees
2009
We study some topological properties of trees with the interval topology. In particular, we characterize trees which admit a 2-fibered compactification and we present two examples of trees whose one-point compactifications are Rosenthal compact with certain renorming properties of their spaces of continuous functions.
On the Oort conjecture for Shimura varieties of unitary and orthogonal types
2014
In this paper we study the Oort conjecture on Shimura subvarieties contained generically in the Torelli locus in the Siegel modular variety $\mathcal{A}_g$. Using the poly-stability of Higgs bundles on curves and the slope inequality of Xiao on fibred surfaces, we show that a Shimura curve $C$ is not contained generically in the Torelli locus if its canonical Higgs bundles contains a unitary Higgs subbundle of rank at least $(4g+2)/5$. From this we prove that a Shimura subvariety of $\mathbf{SU}(n,1)$-type is not contained generically in the Torelli locus when a numerical inequality holds, which involves the genus $g$, the dimension $n+1$, the degree $2d$ of CM field of the Hermitian space,…
Finite cyclicity of some center graphics through a nilpotent point inside quadratic systems
2015
In this paper we introduce new methods to prove the finite cyclicity of some graphics through a triple nilpotent point of saddle or elliptic type surrounding a center. After applying a blow-up of the family, yielding a singular 3-dimensional foliation, this amounts to proving the finite cyclicity of a family of limit periodic sets of the foliation. The boundary limit periodic sets of these families were the most challenging, but the new methods are quite general for treating such graphics. We apply these techniques to prove the finite cyclicity of the graphic $(I_{14}^1)$, which is part of the program started in 1994 by Dumortier, Roussarie and Rousseau (and called DRR program) to show that…
Modular Calabi-Yau threefolds of level eight
2005
In the studies on the modularity conjecture for rigid Calabi-Yau threefolds several examples with the unique level 8 cusp form were constructed. According to the Tate Conjecture correspondences inducing isomorphisms on the middle cohomologies should exist between these varieties. In the paper we construct several examples of such correspondences. In the constructions elliptic fibrations play a crucial role. In fact we show that all but three examples are in some sense built upon two modular curves from the Beauville list.
Deformations of Calabi-Yau manifolds in Fano toric varieties
2020
In this article, we investigate deformations of a Calabi-Yau manifold $Z$ in a toric variety $F$, possibly not smooth. In particular, we prove that the forgetful morphism from the Hilbert functor $H^F_Z$ of infinitesimal deformations of $Z$ in $F$ to the functor of infinitesimal deformations of $Z$ is smooth. This implies the smoothness of $H^F_Z $ at the corresponding point in the Hilbert scheme. Moreover, we give some examples and include some computations on the Hodge numbers of Calabi-Yau manifolds in Fano toric varieties.
Torsors for Difference Algebraic Groups
2016
We introduce a cohomology set for groups defined by algebraic difference equations and show that it classifies torsors under the group action. This allows us to compute all torsors for large classes of groups. We also develop some tools for difference algebraic geometry and present an application to the Galois theory of differential equations depending on a discrete parameter.