Search results for "GAF"
showing 10 items of 34 documents
The macro- and megabenthic fauna on the continental shelf of the eastern Amundsen Sea, Antarctica.
2013
11 pages; International audience; In 2008 the BIOPEARL II expedition on board of RRS James Clark Ross sailed to the eastern Amundsen Sea Embayment and Pine Island Bay, one of the least studied Antarctic continental shelf regions due to its remoteness and ice cover. A total of 37 Agassiz trawls were deployed at depth transects along the continental and trough slopes. A total of 5469 specimens, belonging to 32 higher taxonomic groups and more than 270 species, were collected. Species richness per station varied from 1 to 55. The benthic assemblages were dominated by echinoderms and clearly different to those in the Ross, Scotia and Weddell seas. Here we present the macro- and megafaunal assem…
Large herbivore population and vegetation dynamics 14,600–8300 years ago in central Latvia, northeastern Europe
2019
Abstract This study seeks to explain how the large herbivore (large vertebrate, megafauna – terrestrial taxa with adults > 45 kg) population density changed during abrupt postglacial climate and environmental change. The Lateglacial and Early Holocene (14,600–8300 years ago) were represented by various environmental and climate changes and a transition from a cold to a warm climate, with subsequent changes in flora and fauna. Using Lake Āraisi as a case study (Latvia, northeastern Europe), local to regional vegetation was reconstructed by analyzing plant macroremains and pollen from the lake sediment profile. Here, we present the first dung fungus spore-based qualitative reconstruction of l…
Modelling prey-predator interactions in Messina beachrock pools
2020
Abstract The Strait of Messina (Sicily, Italy) attracts the interest of marine ecologists for the presence of a large variety of habitat and mutually-interacting communities. Among them, beachrock formations, despite their wide geographic distribution, which also includes the Mediterranean area, have been poorly investigated from the biotic viewpoint. In this paper, the spatial and seasonal variability of benthic megafauna from the Messina microtidal beachrock is described. Combining in situ collected data (measurements of abiotic parameters and underwater visual census) with theoretical post-processing analyses (analysis of similarity percentages and cluster analysis), we deduced the possi…
Assessing the role of megafauna in tropical forest ecosystems and biogeochemical cycles - the potential of vegetation models
2018
21 pages; International audience; Megafauna (terrestrial vertebrate herbivores > 5 kg) can have disproportionate direct and indirect effects on forest structure, function, and biogeochemical cycles. We reviewed the literature investigating these effects on tropical forest dynamics and biogeochemical cycles in relation to ecology, paleoecology, and vegetation modelling. We highlight the limitations of field‐based studies in evaluating the long‐term consequences of loss of megafauna. These limitations are due to inherent space‐time restrictions of field‐studies and a research focus on seed dispersal services provided by large animals. We further present evidence of a research gap concerning t…
Doom of the elephant-dependent trees in a Congo tropical forest.
2013
9 pages; International audience; In an evergreen lowland rain forest of the Cuvette Centrale, DR Congo, at the LuiKotale Max-Planck research site, forest elephants (Loxodonta cyclotis) are close to extinction. Between January 2009 and June 2011 we investigated the influence of elephant decline on sustainability of elephant-dispersed tree populations. For this, we explored how trees with the megafaunal syndrome reproduce without seed dispersal by elephants and how does this affect the demography and spatial distribution of these tree species. We studied alternative partners for functional replacement of the elephant. Overall, 18 tree species presenting the megafaunal syndrome were identified…
Continuous wildlife monitoring using blimps as an aerial platform: a case study observing marine megafauna
2020
ABSTRACT Aerial surveys are a powerful means of collecting ecological data in terrestrial and marine systems that may otherwise be difficult to acquire. Increasingly aerial observations are made with Unmanned Aerial Vehicles (UAVs), such as drones. As this technology has improved in reliability and affordability it has replaced the traditional use of fixed-wing aircraft and helicopters. Drones do, however, have limitations; primarily in their limited flight duration, potential to disturb wildlife and concerns over safety. Here we introduce an aerostat, a ground tethered blimp, as a logistically simple and economical alternative to drones and other aircraft. Blimps differ from drones by usin…
Early cave art and ancient DNA record the origin of European bison
2016
The two living species of bison (European and American) are among the few terrestrial megafauna to have survived the late Pleistocene extinctions. Despite the extensive bovid fossil record in Eurasia, the evolutionary history of the European bison (or wisent, Bison bonasus) before the Holocene (<11.7 thousand years ago (kya)) remains a mystery. We use complete ancient mitochondrial genomes and genome-wide nuclear DNA surveys to reveal that the wisent is the product of hybridization between the extinct steppe bison (Bison priscus) and ancestors of modern cattle (aurochs, Bos primigenius) before 120 kya, and contains up to 10% aurochs genomic ancestry. Although undetected within the fossil re…
New Perspectives in the Treatment of Advanced Gastric Cancer: S-1 as a Novel Oral 5-FU Therapy in Combination with Cisplatin
2015
Oral fluoropyrimidines have been available for more than 10 years. Capecitabine is well established in treating solid tumors in Europe. S-1 (Teysuno®), an oral formulation containing the 5-fluorouracil (5-FU) prodrug tegafur and the two enzyme modulators gimeracil and oteracil, has not been available in non-Asia countries until recently. In Japan, S-1 in combination with cisplatin is the recommended first-line treatment in patients with gastric cancer. In Europe, the first trials with S-1 were disappointing due to high unacceptable incidences of adverse events. Pharmacokinetic studies showed differences in Asian and Caucasian patients; therefore, a new non-Asian study program was initiated,…
Oral tegafur in the treatment of gastrointestinal tract cancers: a phase II study.
1990
Fifty patients affected by histologically confirmed gastrointestinal tract cancer (GTC) were treated with oral tegafur (TG) 1,000 mg m-2 p.o. on days 1-14 repeated after a 14 day interval. Out of 42 evaluable patients seven patients had a partial response (PR. 17%) with a median duration of 20.5 weeks, three had a minimal response (7%) with a median duration of 23.7 weeks, nine showed a stabilisation which lasted a median of 31.3 weeks, and 23 progressed (55%). No response was obtained in patients affected by carcinoma of the pancreas and the hepatobiliary system. All PRs were achieved in patients with metastatic disease to the liver. No response was seen in patients with bone, lung or noda…
A phase I study of oral uracil-ftorafur plus folinic acid in combination with weekly paclitaxel in patients with solid tumors.
2002
Ftorafur is an orally available prodrug of 5-fluorouracil (5-FU). Its combination with uracil in a molar ratio of 1:4 (UFT) increases the 5-FU concentration in tumor cells compared with ftorafur alone. Paclitaxel has a broad spectrum of activity against solid tumors and synergic effects with UFT have been demonstrated in vitro. A phase I study was performed to determine the maximum tolerated dose of the combination of UFT and paclitaxel in patients with advanced solid tumors.UFT and folinic acid were applied at 300 mg/m2/day and 90 mg/day, respectively, on days 1-28, repeated on day 36. Paclitaxel was applied on days 1, 8, 15 and 22 of each cycle. The starting dose of paclitaxel was 50 mg/m…