Search results for "GAM"
showing 10 items of 5334 documents
Transforming Experience: The Potential of Augmented Reality and Virtual Reality for Enhancing Personal and Clinical Change
2016
During life, many personal changes occur. These include changing house, school, work, and even friends and partners. However, the daily experience shows clearly that, in some situations, subjects are unable to change even if they want to. The recent advances in psychology and neuroscience are now providing a better view of personal change, the change affecting our assumptive world: (a) the focus of personal change is reducing the distance between self and reality (conflict); (b) this reduction is achieved through (1) an intense focus on the particular experience creating the conflict or (2) an internal or external reorganization of this experience; (c) personal change requires a progression…
Hepatitis C virus (HCV) and autoimmune liver diseases
1992
Anti-HCV tests were positive in 18–45% of sera from patients with autoimmune chronic active hepatitis. High gammaglobulin levels may result in false positive results, however, some sera show true positivity. PCR testing of such sera is necessary in order to determine whether HCV is directly involved in specific forms of the disease.
Measurement of CP asymmetry in Bs0 → Ds ∓K± decays
2014
Journal of high energy physics 2018(3), 59 (2018). doi:10.1007/JHEP03(2018)059
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
2022
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity. This research was funded by the National Na…
Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex
2004
Abstract Background We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen. Baclofen is an agonist of δ-aminobutyric acid type B receptors [GABAB], known to inhibit adenylyl cyclase via Gi. Because these agents have opposite effects on cAMP levels, the unexpected increase in cAMP synthesis when they are applied simultaneously has been intensively investigated. From previous reports, it appears that cyclase type II contributes most significantly to this phenomenon. Results We found that simultaneous application of isoproterenol and baclofen specifically influences the assoc…
Performance of QuantiFERON-TB Gold Plus for detection of latent tuberculosis infection in pregnant women living in a tuberculosis- and HIV-endemic se…
2017
We evaluated the performance of QuantiFERON-TB Gold Plus (QFT-Plus), which includes two Mycobacterium tuberculosis antigen formulations (TB1 and TB2), for detection of latent tuberculosis infection during pregnancy. Eight-hundred-twenty-nine Ethiopian pregnant women (5.9% HIV-positive) were tested with QFT-Plus, with bacteriological sputum analysis performed for women with clinically suspected tuberculosis and HIV-positive women irrespective of clinical presentation. QFT-Plus read-out was categorized according to the conventional cut-off (0.35 IU/ml) for both antigen formulations. In addition, we analysed the distribution of QFT-Plus results within a borderline zone (0.20–0.70 IU/ml), and i…
Factors affecting peak impact force during soccer headers and implications for the mitigation of head injuries
2020
It has been documented that up to 22% of all soccer injuries are concussions. This is in part due to players purposely using their head to direct the ball during play. To provide a more complete understanding of head trauma in soccer athletes, this study characterized the effects of four soccer ball characteristics (size, inflation pressure, mass, velocity) on the resulting peak impact force as it relates to the potential for incurring neurophysiological changes. A total of six hundred trials were performed on size 4 and 5 soccer balls as well as a novel lightweight soccer ball. Impact force was measured with a force plate and ball velocity was determined using motion capture. These data we…
The interpretation of Bach's gamba sonata BWV 1029 on the cello
2006
Masteroppgave i utøvende musikk 2006 - Høgskolen i Agder, Kristiansand The interpretation of Bach’s gamba sonata BWV 1029 on the cello deals with the interpretation of gamba sonatas on the cello from the modern perspective. It is written in the English language by Ana Marinkovic and it is 55 pages long. It is a master thesis from the Agder University College, the Conservatory of Music in Kristiansand Norway, the classical department. Key words in my thesis are: Baroque style, analysis, interpretation, gamba and cello. I am trying to explore the historical interpretation of Baroque music, through the sonata BWV1029 which was written in that period by Johan Sebastian Bach (1685- 1750). Accord…
First gas and thermal measurements at the frequently erupting Gamalama volcano (Indonesia) reveal a hydrothermally dominated magmatic system
2020
Abstract The first gas and thermal measurements at the summit of the Gamalama volcano indicate that the system is dominated by hydrothermal processes. This is highlighted by the prevalence of H2S over SO2 (H2S/SO2 = 2–8), a high CO2/SO2 ratio (76–201), and a low heat transfer (3.0 MW) to the surface. A relative variation in gas composition is observed along the degassing fracture zone, possibly due to partial S scrubbing. Despite this surface hydrothermal signature, the system exhibits high gas equilibrium temperatures (425–480 °C), indicating that fluids are not exclusively derived from a boiling hydrothermal aquifer, but also sourced by cooling and crystallizing basaltic magma at deep tha…
Non-thermal radiation from a pulsar wind interacting with an inhomogeneous stellar wind
2017
Binaries hosting a massive star and a non-accreting pulsar are powerful non-thermal emitters due to the interaction of the pulsar and the stellar wind. The winds of massive stars are thought to be inhomogeneous, which could have an impact on the non-thermal emission. We study numerically the impact of the presence of inhomogeneities or clumps in the stellar wind on the high-energy non-thermal radiation of high-mass binaries hosting a non-accreting pulsar. We compute the trajectories and physical properties of the streamlines in the shocked pulsar wind without clumps, with a small clump, and with a large one. This information is used to compute the synchrotron and inverse Compton emission fr…