Search results for "GAMMA"
showing 10 items of 3093 documents
Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope
2012
The ANTARES telescope observes a full hemisphere of the sky all the time with a duty cycle close to 100%. This makes it well suited for an extensive observation of neutrinos produced in astrophysical transient sources. In the surrounding medium of blazars, i.e. active galactic nuclei with their jets pointing almost directly towards the observer, neutrinos may be produced together with gamma-rays by hadronic interactions, so a strong correlation between neutrinos and gamma-rays emissions is expected. The time variability information of the studied source can be obtained by the gamma-ray light curves measured by the LAT instrument on-board the Fermi satellite. If the expected neutrino flux ob…
Influence of gamma-aminobutyric acid on baclofen intestinal absorption.
1994
Since previous studies suggested that baclofen absorption in the rat middle intestine was inhibited by beta-alanine and therefore mediated, at least in part, by the beta-aminoacid carrier, we focused our new studies on the analysis of the possible inhibition of the drug by a gamma-aminoacid model compound, gamma-aminobutyric acid (GABA). A rat jejunum in situ study was undertaken in order to evaluate the effect of GABA on baclofen absorption and to establish the inhibition model. Assays using isotonic perfusion solutions of 0.5 mM baclofen with starting GABA concentrations ranging from 0 to 100 mM are reported. The results show that the absorption rate pseudoconstants of the drug decrease a…
Intestinal absorption pathway of gamma-aminobutyric acid in rat small intestine.
1994
Intestinal absorption of gamma-aminobutyric acid (GABA), as a model compound for gamma-aminoacids, has not been extensively studied from the kinetic viewpoint. Since data from our laboratory suggested that some competition arises between intestinal absorption of beta-alanine and GABA and since our intent was to maintain the aqueous stagnant diffusion layer in order to approach absorption tests to in vivo physiological conditions, a rat jejunum in situ study was undertaken in order to gain an insight into the mechanism of GABA absorption. In the present paper, results from assays using isotonic perfusion solutions with starting GABA concentrations ranging from 1 to 50 mM are reported. They s…
An in-depth evaluation of acalabrutinib for the treatment of mantle-cell lymphoma
2020
Introduction: Regimens involving intensive immuno-chemotherapy, followed by high-dose therapy and autologous stem cell transplant represent the standard treatment for younger fit patients with mantle cell lymphoma (MCL). Targeted approaches (i.e. ibrutinib, bortezomib, and lenalidomide) represent the backbone of therapy for relapsed cases. Areas covered: Acalabrutinib is a novel small molecule with a butynamide moiety specifically designed to irreversibly inhibit Bruton tyrosine kinase (BTK), which is more potent and selective than ibrutinib. Relevant publications have been identified through literature searches using the terms 'mantle cell lymphoma' and 'acalabrutinib'. Expert opinion: Aca…
International workshop on next generation gamma-ray source
2022
Journal of physics / G 49(1), 010502 (2022). doi:10.1088/1361-6471/ac2827
Accrétion et éjection dans les systèmes binaires X transitoires à trous noirs : le cas de GRS 1716-249
2020
I buchi neri transienti (BHT) sono tra le sorgenti con emissione ai raggi X più luminose della galassia. Grazie all’elevato flusso in banda X e alla loro alta variabilità temporale. queste sorgenti offrono un’opportunità unica per studiare la fisica dell’accrescimento in straordinareie condizioni fisiche. I BHT mostrano episodici outburst caratterizzati da diverse luminosità in banda X e γ, diverse forme spettrali e proprietà della variabilità temporale. L’obiettivo di questa tesi è lo studio della geometria, dei meccanismi e dei processi fisici coinvolti nell’emissione del buco nero transiente GRS 716-249. Di seguito presento l’analisi spettrale e temporale delle osservazioni della GRS 171…
A radiometric and petrographic approach to risk assessment at Alte Madonie Mounts region (Sicily, Italy)
2013
The main goal of this work was to assess the radiological hazard at Alte Madonie Mounts region (north-central Sicily, Italy) in response to rumours of an increase in the incidence of cancer in this area. A correlation between the natural radionuclide contents and the petrographic features of the soil and rock samples was also evaluated. A total of 41 samples of selected soils and rocks were collected, powdered, dried and sealed in 'Marinelli' beakers for 20 d prior to measurement to ensure that a radioactive equilibrium between (226)Ra and (214)Bi had been reached. A gamma-ray spectrometer was used to quantify the radioactivity concentrations. To determine (238)U and (232)Th activities, the…
Unsupervised low-key image segmentation using curve evolution approach
2013
Low-key images widely exist in imaging-based systems such as space telescopes, medical imaging equipment, machine vision systems. Unsupervised low-key image segmentation is an important process for image analysis or digital measurement in these applications. In this paper, a novel active contour model with the probability density function (PDF) of gamma distribution for image segmentation is proposed. The flexible gamma distribution is used to describe both of the heterogeneous foreground and dark background in a low-key image. Besides, an unsupervised curve initialization method is also designed in this paper, which helps to accelerate the convergence speed of curve evolution. The effectiv…
First Multi-wavelength Campaign on the Gamma-ray-loud Active Galaxy IC 310
2017
The extragalactic VHE gamma-ray sky is rich in blazars. These are jetted active galactic nuclei viewed at a small angle to the line-of-sight. Only a handful of objects viewed at a larger angle are known so far to emit above 100 GeV. Multi-wavelength studies of such objects up to the highest energies provide new insights into the particle and radiation processes of active galactic nuclei. We report the results from the first multi-wavelength campaign observing the TeV detected nucleus of the active galaxy IC 310, whose jet is observed at a moderate viewing angle of 10 deg - 20 deg. The multi-instrument campaign was conducted between 2012 Nov. and 2013 Jan., and involved observations with MAG…
Long-term monitoring of mrk 501 for its very high energy γ emission and a flare in 2011 october
2012
"As one of the brightest active blazars in both X-ray and very high energy γ -ray bands, Mrk 501, is very useful for" "physics associated with jets from active galactic nuclei. The ARGO-YBJ experiment has monitored Mrk 501 for γ - rays above 0.3 TeV since 2007 November. The largest flare since 2005 was observed from 2011 October and lasted until about 2012 April. In this paper, a detailed analysis of this event is reported. During the brightest γ -ray flaring episodes from 2011 October 17 to November 22, an excess of the event rate over 6σ is detected by ARGO-YBJ in the direction of Mrk 501, corresponding to an increase of the γ -ray flux above 1 TeV by a factor of 6.6 ± 2.2 from its steady…