Search results for "GBM"
showing 8 items of 8 documents
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.
2019
Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose, we analyzed the status of EGFR and the somatic copy number alterations (CNAs) of a set of tumor suppressor genes and oncogenes. Thus, we found GBMs with high level of EGFR amplification, low level and with no EGFR amplification. Highly amplified tumors showed histological features of…
Reāllaika laikrindu analīze prognozēšanai un anomāliju detektēšanai
2021
Šajā darbā tiek aprakstīts laikrindu anomāliju noteikšanas modeļa izstrādes process un tā realizācija. Darbs tiek balstīts uz temperatūras mērījumu sensoru datiem. Anomāliju noteikšanas modeļa izstrādes ietvaros tiek apskatītas sekojošas tēmas - simulāciju veidošanda, laikrindu analīze, laikrindu priekšapstrāde, laikrindu klasterēšana, laikrindu prognozējošo modeļu izveide, anomāliju noteikšana un modeļu ansambļa izveide. Darba mērķis ir apskatīt dažāda tipa modeļus, metodes un to apvienojumus, lai izveidotu robustu anomāliju noteikšanas modeļu ansambli. Darba rezultātā tika izveidots laikrindu anomāliju noteikšanas modeļu ansamblis, kura pamatā ir četri modeļi - LightGBM, LSTM, Holt-Winter…
Absence of Anti-Glomerular Basement Membrane Antibodies in 200 Patients With Systemic Lupus Erythematosus With or Without Lupus Nephritis: Results of…
2020
IntroductionAnti-glomerular basement membrane (GBM) antibodies are pathogenic antibodies first detected in renal-limited anti-GBM disease and in Goodpasture disease, the latter characterized by rapidly progressive crescentic glomerulonephritis combined with intra-alveolar hemorrhage. Studies have suggested that anti-GBM antibody positivity may be of interest in lupus nephritis (LN). Moreover, severe anti-GBM vasculitis cases in patients with systemic lupus erythematosus (SLE) have been described in the literature, but few studies have assessed the incidence of anti-GBM antibodies in SLE patients.ObjectiveThe main study objective was to determine if positive anti-GBM antibodies were present …
Ecophysiological Modeling of Grapevine Water Stress in Burgundy Terroirs by a Machine-Learning Approach
2016
13 pages; International audience; In a climate change scenario, successful modeling of the relationships between plant-soil-meteorology is crucial for a sustainable agricultural production, especially for perennial crops. Grapevines (Vitis vinifera L. cv Chardonnay) located in eight experimental plots (Burgundy, France) along a hillslope were monitored weekly for 3 years for leaf water potentials, both at predawn (Ψpd) and at midday (Ψstem). The water stress experienced by grapevine was modeled as a function of meteorological data (minimum and maximum temperature, rainfall) and soil characteristics (soil texture, gravel content, slope) by a gradient boosting machine. Model performance was a…
The chaperone system in glioblastoma multiforme and derived cell lines: diagnostic and mechanistic implications.
2022
BACKGROUND: Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. Novel treatments are needed to counteract the molecular mechanisms of GBM growth and drug resistance. The chaperone system (CS) members are typically cytoprotective but some, termed Hsp, can become pathogenic and participate in carcinogenesis, along with the vascular endothelial growth factor (VEGF), and we investigated them in GBM biopsies and derived cell lines. The objectives were to identify diagnostic-prognostic biomarkers and gather information for developing chaperonotherapy. METHODS: Cell lines from GBMs were established, characterized (morphology, growth characteristics, and sp…
Liquid Biopsy in Diagnosis and Prognosis of High-Grade Gliomas; State-of-the-Art and Literature Review
2022
Gliomas, particularly high-grade gliomas, represent the most common and aggressive tumors of the CNS and are still burdened by high mortality and a very poor prognosis, regardless of the type of therapy. Their diagnosis and monitoring rely on imaging techniques and direct biopsy of the pathological tissue; however, both procedures have inherent limitations. To address these limitations, liquid biopsies have been proposed in this field. They could represent an innovative tool that could help clinicians in the early diagnosis, monitoring, and prognosis of these tumors. Furthermore, the rapid development of next-generation sequencing (NGS) technologies has led to a significant reduction in seq…
Gradientu pastiprināšanas algoritmu salīdzinājums un mainīgo būtiskuma analīze
2020
Šajā darbā tiek izpētīti un salīdzināti trīs no jaunākiem un plaši izmantotiem gradienta pastiprināšanas algoritmiem - XGBoost, LightGBM un CatBoost. Šie algoritmi tiek salīdzināti pēc to ātrdarbības, kā arī tendences uz pārpielāgošānos treniņa datiem. Tiek analizēta arī šo algoritmu spēja izmantot modelēšanā kategoriskus mainīgos. Papildus tiek izpētīti algoritmu hiperparametri un to ietekme uz algoritma pārpielāgošanos un modeļa precizitātes rādītājiem. Balstoties uz rezultātiem, tiek sniegti ieteikumi par hiperparametru skaņošanu. Otrajā eksperimenta daļā tiek izpētīta uz spēļu teorijas Šaplī vērtību balstītā metode mainīgo būtiskuma noteikšanai. Iegūtiem rādītājiem ar būtstrapa metodes …
A molecular hypothesis to explain direct and inverse co-morbidities between Alzheimer's Disease, Glioblastoma and Lung cancer.
2017
Epidemiological studies indicate that patients suffering from Alzheimer’s disease have a lower risk of developing lung cancer, and suggest a higher risk of developing glioblastoma. Here we explore the molecular scenarios that might underlie direct and inverse co-morbidities between these diseases. Transcriptomic meta-analyses reveal significant numbers of genes with inverse patterns of expression in Alzheimer’s disease and lung cancer, and with similar patterns of expression in Alzheimer’s disease and glioblastoma. These observations support the existence of molecular substrates that could at least partially account for these direct and inverse co-morbidity relationships. A functional analy…