Search results for "GC"

showing 10 items of 606 documents

Pan-cancer analysis of whole genomes

2020

Publisher's version (útgefin grein)

Maletert promoter mutationsCancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2]DNA Mutational AnalysisNormal tissuesystematic analysisGermlineTranscriptome0302 clinical medicineAetiologyCàncerCellular SenescenceCancer0303 health sciencesdna-damageMassive parallel sequencingPan cancerREARRANGEMENTSHigh-Throughput Nucleotide SequencingGenomicsSciences bio-médicales et agricolesTelomereCOMPREHENSIVE3. Good healthTERT PROMOTER MUTATIONSsignatures030220 oncology & carcinogenesisScience & Technology - Other TopicsErfðarannsóknirHuman:Informàtica::Aplicacions de la informàtica::Bioinformàtica [Àrees temàtiques de la UPC]EvolutionRNA SplicingGenomicsArticleEvolution MolecularStructural variationRC025403 medical and health sciencesSDG 3 - Good Health and Well-beingGeneticgenomicsSYSTEMATIC ANALYSISGeneticsGenomics--Databases.HumansGenetic TestingMolecular BiologySIGNATURESWhole genome sequencing1000 MultidisciplinaryChromothripsisScience & TechnologyRC0254 Neoplasms. Tumors. Oncology (including Cancer)Information DisseminationResearchInstitutes_Networks_Beacons/mcrcPreventionBiology and Life SciencesMolecularOncogenesCloud Computingmedicine.diseaseGenòmicaCompute cloudsMutation570 Life sciences; biologyCOMPREHENSIVE CHARACTERIZATIONGenèticaWhole Genome Sequencing--methodsBackground informationDNA Mutational Analysis ; Evolution ; Genetic / genetics ; Genome ; Genomics ; Germ-Line Mutation / genetics ; High-Throughput Nucleotide Sequencing ; Human / genetics ; Humans ; ICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumMedizinGenomeWhole-genomeGenome mappingNeoplasms2.1 Biological and endogenous factorsPromoter Regions GeneticCàncer -- Aspectes genèticsTelomeraseGeneticsWomen's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17]MultidisciplinaryChromothripsisGenomeManchester Cancer Research Centregenomics cancer profiling3rd-DAS10124 Institute of Molecular Life SciencesWomen's cancers Radboud Institute for Health Sciences [Radboudumc 17]Multidisciplinary SciencesParallel sequencingICGC/TCGA Pan-Cancer Analysis of Whole Genomes ConsortiumFemaleprofilingMedical GeneticsEngineering sciences. TechnologyBiotechnologyGeneral Science & TechnologyThe Cancer Genome Atlas610 Medicine & healthComputational biologyQH426 GeneticsBiologyConsortium of the International Cancer Genome ConsortiumPromoter RegionsGermline mutationPan-cancer analysisKrabbameinsrannsóknirmedicinecancerddc:610QH426Germ-Line MutationMedicinsk genetikKrabbamein030304 developmental biologyCell ProliferationLANDSCAPEGenome Humancomprehensive characterizationPan-cancer analysis of whole genomesPoint mutationHuman GenomeCancerReproducibility of ResultsSOMATIC MUTATIONSEVOLUTIONCancer sequencing Chromothripsis telomereDNA-DAMAGEMutagenesisPATTERNS3111 BiomedicineCHARACTERIZATION
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Late Pleistocene (MIS 3-4) climate inferred from micromammal communities and δ18O of rodents from Les Pradelles, France.

2013

The middle Paleolithic stratigraphic sequence of Les Pradelles (Charente, France) spans from the end of Marine Isotope Stage (MIS) 4 until the middle of MIS 3. Micromammal remains are present in all the stratigraphic levels, offering a rare opportunity to address the questions of both environmental and climatic fluctuations throughout this period. Climate modes were studied through the taphonomy, biodiversity and oxygen isotope compositions of phosphate (δ18O p ) from 66 samples of rodent tooth enamel. The δ18O p values from the lower sedimentary levels provide summer mean air temperatures of 19 ± 2°C (level 2/1) and of 16 ± 2°C (levels 2A, 2B and 4A). Within the middle of sequence (level 4…

Marine isotope stage010506 paleontologyTaphonomy010504 meteorology & atmospheric sciencesPleistoceneClimate[SDE.MCG]Environmental Sciences/Global ChangesPhosphate01 natural sciencesArts and Humanities (miscellaneous)[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/GeochemistryMiddle PaleolithicSmall mammalsDicrostonyx torquatusSequence stratigraphyMicrotus0105 earth and related environmental sciencesEarth-Surface Processes[ SDU.STU.PG ] Sciences of the Universe [physics]/Earth Sciences/PaleontologyRodentbiologyEcology15. Life on landbiology.organism_classification[ SDU.STU.GC ] Sciences of the Universe [physics]/Earth Sciences/GeochemistryLes PradellesOxygen isotopePleistocene[ SDE.MCG ] Environmental Sciences/Global Changes13. Climate actionPaleoecologyGeneral Earth and Planetary Sciences[SDU.STU.PG]Sciences of the Universe [physics]/Earth Sciences/Paleontology
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Exploring the challenges of remote work on Twitter users’ sentiments: From digital technology development to a post-pandemic era

2022

The boost in the use and development of technology, spurred by COVID-19 pandemic and its consequences, has sped up the adoption of new technologies and digital platforms in companies. Specifically, companies have been forced to change their organizational and work structures. In this context, the present study aims to identify the main opportunities and challenges for remote work through the use of digital technologies and platforms based on the analysis of user-generated content (UGC) in Twitter. Using computer-aided text analysis (CATA) and natural language processing (NLP), in this study, we conduct a sentiment analysis developed with Textblob, which works with machine learning. We then …

Marketingcomputer-aided text analysissentiment analysistopic modelingremote workingtwitterUNESCO::CIENCIAS ECONÓMICASUGC
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Différentes approches pour la datation U/Pb des tonsteins intercalés dans les séries continentales d’âge fini-carbonifère à permien de Lucenay-lès-Ai…

2018

International audience; D’une manière générale, la présence de niveaux volcaniques (cendres ou laves) intercalés dans les séries sédimentaires présente un avantage non négligeable pour dater la sédimentation de ces séries. Des datations précises peuvent même permettre d’estimer des taux de sédimentation, ou encore de proposer des corrélations à l’échelle de différents bassins.Les séries sédimentaires du Carbonifère-Permien de Lucenay-lès-Aix, étudiées par forage, sont géographiquement situées entre des séries de même âge connues à l’affleurement : Decize-La Machine (au nord), Aumance (à l’ouest) et Autun (à l’est). Ce (ou ces) bassin(s) sont consti- tués de dépôts continentaux dans lesquels…

Massif Centralcarbonifèrebassins[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistry[SDU.STU.GC] Sciences of the Universe [physics]/Earth Sciences/GeochemistrypermienvarisquehercynienU/Pbgéochronologie
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Caractérisation pétro-géochimique et datation U/Pb du volcanisme contemporain des bassins d’âge fini-Carbonifère à Permien du Nord du Massif Central

2018

International audience; La formation de la chaîne hercynienne, dont l’apogée a lieu au Carbonifère, participe à l’assemblage de la Pangée, qui se démantèlera par la suite à partir du Trias. La limite Carbonifère- Permien correspond donc à une période clé dans l’évolution géodynamique globale, à la transition entre une période orogénique et une période de rifting. Cependant, les reconstitutions paléogéographiques et paléoclimatiques pour cette époque sont assez peu contraintes, notamment du fait du manque de datations radiométriques et de corrélations stratigraphiques fiables entre les différents domaines sédimentaires. Plusieurs bassins sédimentaires fini-carbonifères à permiens sont préser…

Massif Centralcarbonifèrebassins[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistrypermien[SDU.STU.GC] Sciences of the Universe [physics]/Earth Sciences/GeochemistryvarisqueU/Pbhercyniengéochronologie
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A multi-technique characterisation of cronstedtite synthetized by iron-clay interaction in a step by step cooling procedure

2013

International audience; The cooling of steel containers in radioactive-waste storage was simulated in a step-by-step experiment from 90 to 40 degrees C. Among newly formed clay minerals observed in run products, cronstedtite was identified by a number of analytical techniques (powder X-ray diffraction, transmission electron microscopy, and scanning electron microscopy). Cronstedtite has not previously been recognized to be so abundant and so well crystallized in an iron-clay interaction experiment. The supersaturation of experimental solutions with respect to cronstedtite was due to the availability of Fe and Si in solution, as a result of the dissolution of iron metal powder, quartz, and m…

Materials scienceBase (chemistry)Analytical chemistry[SDU.STU]Sciences of the Universe [physics]/Earth SciencesSoil Science020101 civil engineering02 engineering and technology010502 geochemistry & geophysics01 natural sciencesCronstedtite; Experimental iron-clay interaction; MDO polytypes; Radioactive waste storage0201 civil engineeringDiffraction tomographyGeochemistry and Petrology[SDU.STU.GC]Sciences of the Universe [physics]/Earth Sciences/Geochemistryradioactive waste storageEarth and Planetary Sciences (miscellaneous)experimental iron-clay interactionDissolutionQuartz[SDU.STU.AG]Sciences of the Universe [physics]/Earth Sciences/Applied geologyMDO polytypes0105 earth and related environmental sciencesWater Science and Technologychemistry.chemical_classificationSupersaturationAtmospheric temperature rangeCronstedtiteCrystallographychemistrySelected area diffractionClay minerals[SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
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Detection of Irradiated Food and Evaluation of the Given Dose by Electron Spin Resonance, Thermoluminescence, and Gas Chromatographic/Mass Spectromet…

2018

Abstract The treatment of food with ionizing radiation, at doses lower than 10 kGy, is a preservation technology, which can be used to reduce food spoilage due to microorganisms and to decrease insect infestation, enhancing, in the same time, the hygienic quality, extending the shelf life of food itself. In order to increase the general consumer acceptance and accordingly to facilitate the commercialization and trade of irradiated food, the European Committee for Standardization (CEN) validated reliable analytical techniques to identify irradiated foodstuffs for legal control purposes, distinguished in Chemical, Physical, and Microbiological ones, depending on the characteristics of marker …

Materials scienceChromatographyFood spoilageShelf lifeMass spectrometricThermoluminescenceSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)law.inventionIonizing radiationlawFood irradiationIrradiationCellulose ESR signal Food spoilage GC/MS analysis Ionizing radiation. Irradiation Pathogenic bacteria Tl techniqueElectron paramagnetic resonance
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Cell and tissue response to nanotextured Ti6Al4V and Zr implants using high-speed femtosecond laser-induced periodic surface structures

2019

In this paper, the effect of femtosecond laser nanotexturing of surfaces of Ti6Al4V and Zr implants on their biological compatibility is presented and discussed. Highly regular and homogeneous nanostructures with sub-micrometer period were imprinted on implant surfaces. Surfaces were morphologically and chemically investigated by SEM and XPS. HDFa cell lines were used for toxicity and cell viability tests, and subcutaneous implantation was applied to characterize tissue response. HDFa proliferation and in vivo experiments evidenced the strong influence of the surface topography compared to the effect of the surface elemental composition (metal or alloy). The effect of protein adsorption fro…

Materials scienceNanostructureSurface PropertiesBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)chemistry.chemical_elementBioengineering02 engineering and technologyOsseointegrationCell proliferation; Femtosecond laser; Fluorescence; HR-LIPSS; Nanotexturing; Cell Differentiation; Humans; Lasers; Nanostructures; Osseointegration; Osteoblasts; Osteogenesis; Surface Properties; Titanium; Zirconium; Prostheses and ImplantsFluorescencelaw.invention03 medical and health sciencesX-ray photoelectron spectroscopylawOsseointegrationOsteogenesisAlloysHumansGeneral Materials ScienceCell proliferation030304 developmental biologyTitanium0303 health sciencesOsteoblastsLasersTitanium alloyCell DifferentiationProstheses and Implants021001 nanoscience & nanotechnologyLaserNanotexturingNanostructuresFemtosecond laserchemistryFemtosecondBiophysicsMolecular MedicineHR-LIPSSZirconiumNanotexturingCell proliferationFluorescenceHR-LIPSSFemtosecond laser0210 nano-technologyTitaniumProtein adsorption
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Sejas un žokļu traumas Paula Stradiņa Klīniskajā Universitātes slimnīcā

2020

Sejas un žokļu traumu ietekme uz hospitalizācijas ilgumu un neiroloģisko simptomātiku Paula Stradiņā Klīniskajā Universitātes slimnīcā. Viena no plašākajām traumu kategorijām, kas tieši pieder pie jebkuras valsts galvenajām sociālekonomiskajām problēmām un skar visus pasaules iedzīvotāju slāņus, un ir galvaskausa, sejas un apakšžokļu traumas. Sejas traumas ir bieži izplatītas, jo seja ir visatklātākā un neaizsargātākā ķermeņa daļa ar nelielu aizsargpārklājumu. Mutes dobuma un augšžokļa sejas traumas, papildus sejas estētikai, ietekmē tādas funkcijas kā elpošana, košļāšanas, rīšanas un runas funkcijas. Darba mērķi: noskaidrot FISS skalas ietekmi uz pareģojošo pacientu hospitalizācijas ilgumu…

Maxillofacial fracture; Midface fractures; Management of frontal sinus fractures; Surgical treatment at midface trauma; History of LeFort classification and study;Corelation betwen FISS and GCS scales;FISS scale and hospitalisation timeNOE fractures; FISS scale; GCS scale;MedicīnaSurgycal treatment of mandibular fracture; ORIF
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Bayesian calibration of the nitrous oxide emission module of an agro-ecosystem model

2008

1. NitroEurope Open Science Conference on Reactive Nitrogen and the European Greenhouse Gas Balance ; Ghent (Belgique) - (2008-02-20 - 2008-02-21) / Conférence; Nitrous oxide (N2O) is the main biogenic greenhouse gas contributing to the global warming potential (GWP) of agro-ecosystems. Evaluating the impact of agriculture on climate therefore requires a capacity to predict N2O emissions in relation to environmental conditions and crop management. Biophysical models simulating the dynamics of carbon and nitrogen in agro-ecosystems have a unique potential to explore these relationships, but are fraught with high uncertainties in their parameters due to their variations over time and space. H…

Mean squared error[SDE.MCG]Environmental Sciences/Global ChangesBayesian probabilityparameter uncertainty010501 environmental sciencesAtmospheric sciences7. Clean energy01 natural sciencesEcology and Environment[ SDV.EE ] Life Sciences [q-bio]/Ecology environmentsymbols.namesake[STAT.AP] Statistics [stat]/Applications [stat.AP]Ecosystem modelgreenhouse gasesMarkov Chain Monte Carlo0105 earth and related environmental sciences2. Zero hunger[SDV.EE]Life Sciences [q-bio]/Ecology environment[STAT.AP]Statistics [stat]/Applications [stat.AP]EcologyMarkov chainnitrous oxideEcology[ STAT.AP ] Statistics [stat]/Applications [stat.AP]Global warmingMarkov chain Monte Carlo04 agricultural and veterinary sciences15. Life on land[ SDE.MCG ] Environmental Sciences/Global Changes[SDV.EE] Life Sciences [q-bio]/Ecology environment[SDE.MCG] Environmental Sciences/Global ChangesAgriculture and Soil Science13. Climate actionGreenhouse gas040103 agronomy & agriculturesymbols0401 agriculture forestry and fisheriesEnvironmental scienceProbability distributionAnimal Science and ZoologyCERES-EGCAgronomy and Crop Sciencebayesian calibration
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