Search results for "GDO"

Vectors of tick-borne diseases and epidemiological situation in Latvia in 1993-2002.

2004

During the period of 1993-2002 an increase and the remarkable changes in the incidence of tick-borne encephalitis (TBE) and Lyme borreliosis (LB) as well as annual activities of vector species were noticed. The highest increase of TBE morbidity in Latvia has been observed in 1994 and 1995, and less expressed also in 1998 which was followed by a significant decrease during subsequent years. Whereas the highest peak of LB morbidity has been noticed in 1998 with only a minor decrease during subsequent years. Two epidemiologically significant Ixodes tick species are common in Latvia. Ixodes ricinus L. spread in the western and central part of Latvia; but rarely and in small numbers also in the …

Global distribution of Mycobacterium tuberculosis spoligotypes.

2002

Since the publication of the second version of our spoligotypes database on Mycobacterium tuberculosis (1), the causative agent of tuberculosis (TB), the proportion of clustered isolates (shared types [STs]) increased from 84% (2,779/3,319) to 90% (11,708/13,008). Fifty percent of the clustered isolates were found in only 20 STs. Three of these isolates are M. bovis, including M. bovis BCG (ST 481, 482, and 683). The addition of the next 30 most frequent STs increased the total proportion of clustered isolates (65% instead of 50% initially). A total of 36 potential subfamilies or subclades of M. tuberculosis complex have been tentatively identified, leading to the definition of major and mi…

2021

Lyme borreliosis is a multisystemic disease caused by the pleomorphic bacteria of theBorrelia burgdorferi sensu latocomplex. The exact mechanisms for the infection to progress into a prolonged sequelae of the disease are currently unknown, although immune evasion and persistence of the bacteria in the host are thought to be major contributors. The current study investigatedB. burgdorferiinfection processes in two human cell lines, both non-immune and non-phagocytic, to further understand the mechanisms of infection of this bacterium. By utilizing light, confocal, helium ion, and transmission electron microscopy, borrelial infection of chondrosarcoma (SW1353) and dermal fibroblast (BJ) cells…

Structural and Functional Analysis of BBA03, Borrelia burgdorferi Competitive Advantage Promoting Outer Surface Lipoprotein

2020

BBA03 is a Borrelia burgdorferi outer surface lipoprotein encoded on one of the most conserved plasmids in Borrelia genome, linear plasmid 54 (lp54). Although many of its genes have been identified as contributing or essential for spirochete fitness in vivo, the majority of the proteins encoded on this plasmid have no known function and lack homologs in other organisms. In this paper, we report the solution NMR structure of the B. burgdorferi outer surface lipoprotein BBA03, which is known to provide a competitive advantage to the bacteria during the transmission from tick vector to mammalian host. BBA03 shows structural homology to other outer surface lipoproteins reflecting their genetic …

Identification of Three Clinically Relevant Borrelia burgdorferi Sensu Lato Genospecies by PCR-Restriction Fragment Length Polymorphism Analysis of 1…

2004

ABSTRACT We report the results of a study of the prevalences of three clinically relevant Borrelia burgdorferi sensu lato genospecies ( Borrelia burgdorferi sensu stricto, Borrelia afzelii , and Borrelia garinii ) in 1,040 questing Ixodes ticks from all regions of Latvia, where Lyme borreliosis is endemic. The prevalences of Borrelia in Ixodes ricinus and Ixodes persulcatus were 22.6 and 27.9%, respectively. Molecular typing of B. burgdorferi from infected ticks was performed by restriction fragment length polymorphism (RFLP) analysis of PCR-amplified fragments of the 16S-23S ( rrs-rrlA ) rRNA intergenic spacer by using species-specific primers and subsequent sequencing. The dominant Borrel…

Lyme neuroborreliosis with encephalitis; a systematic literature review and a Scandinavian cohort study

2022

Background Lyme neuroborreliosis (LNB) presenting with encephalitis is rare and scarcely described. Objectives To describe the available literature on LNB encephalitis and to characterize this patient group through a Scandinavian retrospective cohort study. Data sources Medline, Embase, Scopus, Cochrane library. Study eligibility criteria There was no discrimination on study type, time of publication or language. Participants Review: All articles with definite LNB and confirmed/possible encephalitis. Cohort: LNB cohorts from Denmark, Sweden and Norway 1990–2019 were screened for patients with encephalitis. Methods Review: Adhering to PRISMA guidelines; two authors extracted reviews and asse…

Minerali, piante, animali e uomini: indagine lessicale sul rapporto tra i regni naturali e l’ambiente nella Grecia antica

2021

L’articolo indaga il rapporto che sussiste nella Grecia antica tra la terra e i cosiddetti «regni naturali» (minerale, vegetale, animale, umano) alla luce del lessico utilizzato per indicarlo e mostra che, a differenza di quanto avviene presso di noi, esso è spesso analogo per tutti e quattro gli ambiti. L’azione della terra (o altri elementi eco-sistemici) nei confronti degli elementi che appartengono ai diversi regni, infatti, è tendenzialmente designata dagli stessi verbi (vengono presi in considerazione phýein, ghennán, bóskein, tréphein, phérein, anadidónai): la terra phýei (e ugualmente possono essere usati anche gli altri verbi) sia uomini, sia animali, sia piante, sia minerali. Th…

Gracia y gobierno en la administración valenciana del seiscientos. Hacia nuevos consensos

2015

Desde 1645 dos miembros de la nobleza local entraron a formar parte de la sala criminal de la Audiencia valenciana. Como consejeros de capa y espada asumieron competencias en materias de gracia y gobierno. Con esta medida se introdujo una moderación del arbitrio virreinal en tales ejercicios. Pero, sobre todo, la corona convirtió a la pequeña y mediana nobleza del reino en nueva colaboradora de su política de control estamental. From 1645 two members of the local nobility came to form part of the Criminal Chamber of the Valencian audience. As Ministers of «capa y espada» took powers in matters of Grace and Government. This measure was introduced a moderation of the Viceregal discretion in s…

The protection of minority shareholders during delisting in Germany and in the U.K.

2020

The thesis seeks to compare the protection of minority shareholders during delisting in Germany and in the UK. Delisting refers to a publicly traded company leaving the stock market. In order to compare the protection afforded by the relevant legislator the thesis first seeks to give an overview of the interests touched upon by delisting, finding the main risk for minority shareholders is unlike often assumed not a loss of value but the loss of the share’s tradability. The thesis then compares the approach taken towards the problem and the instruments utilized by both legislators. Here the thesis finds that the German law represents a stricter and inflexible solution, while the British law …

Structure of an outer surface lipoprotein BBA64 from the Lyme disease agent Borrelia burgdorferi which is critical to ensure infection after a tick b…

2013

Lyme disease is a tick-borne infection caused by the transmission of Borrelia burgdorferi from infected Ixodes ticks to a mammalian host during the blood meal. Previous studies have shown that the expression of B. burgdorferi surface-localized lipoproteins, which include BBA64, is up-regulated during the process of tick feeding. Although the exact function of BBA64 is not known, this lipoprotein is critical for the transmission of the spirochete from the tick salivary glands to the mammalian organism after a tick bite. Since the mechanism of development of the disease and the functions of the surface lipoproteins associated with borrel­iosis are still poorly understood, the crystal structur…