Search results for "GELS"

Probing the Gelation Synergies and Anti-Escherichia coli Activity of Fmoc-Phenylalanine/Graphene Oxide Hybrid Hydrogel

2023

The N-fluorenyl-9-methyloxycarbonyl (Fmoc)-protected amino acids have shown high antimicrobial application potential, among which the phenylalanine derivative (Fmoc-F) is the most well-known representative. However, the activity spectrum of Fmoc-F is restricted to Gram-positive bacteria only. The demand for efficient antimicrobial materials expanded research into graphene and its derivatives, although the reported results are somewhat controversial. Herein, we combined graphene oxide (GO) flakes with Fmoc-F amino acid to form Fmoc-F/GO hybrid hydrogel for the first time. We studied the synergistic effect of each component on gelation and assessed the material’s bactericidal activity on Gram…

Incorporation of dynamic boronate links and Ag nanoparticles into PVA hydrogels for pH-Regulated and prolonged release of methotrexate

2021

Abstract In this study, pH-responsive hydrogels based on PVA-boronate crosslinks were prepared via a simple route and used for controlled and targeted delivery of anticancer drug methotrexate. A double network (DN) hydrogel composed of didiol-boronate/PVA complex as the first network and PVA crystallites generated by a freeze-thaw process as the second one was developed. The swelling of PVA-boronate DN hydrogels demonstrated high sensitivity to multiple stimuli including the pH, temperature, and ionic strength of the media thanks to the dynamic boronate links in the first network. Moreover, unlike previously reported hydrogels based on the boronate linkages, the new DN hydrogels preserved t…

Biodistribution of Insulin-Nanogels in Mouse: A Preliminary Study for the Treatment of Alzheimer's Disease

2017

A growing body of evidence shows that Insulin, Insulin Receptor (IR) and IR signaling are involved in brain cognitive functions and their dysfunction is implicated in Alzheimer's disease (AD) neurodegeneration. Thus, administration of insulin could be a strategy for AD treatment. For this aim we have designed, synthesized and characterized a nanogel system (NG) that has been conjugated to insulin molecules (NG-In) to deliver the protein into the brain, as a tool for the development of a new therapy against AD. In our preclinical study in mice, intraperitoneal injection of fluorescent-labeled NG has allowed to determine the biodistribution of NG vs time in the whole body and its clearance th…

Ionic liquids: a highway with many lanes

Ionogels formed by geminal imidazolium salts: a preliminary investigation

Rapid self-healing and anion selectivity in metallosupramolecular gels assisted by fluorine-fluorine interactions.

2017

Simple ML2 [M = Fe(II), Co(II), Ni(II)] complexes obtained from a perfluoroalkylamide derivative of 4-aminophenyl-2,2′,6,2′-terpyridine spontaneously, yet anion selectively, self-assemble into gels, which manifest an unprecedented rapid gel strength recovery, viz. self-healing, and thermal rearrangement in aqueous dimethyl sulfoxide. The key factor for gelation and rheological properties emerges from the fluorine–fluorine interactions between the perfluorinated chains, as the corresponding hydrocarbon derivative did not form metallogels. The perfluoro-terpyridine ligand alone formed single crystals, while its Fe(II), Co(II) or Ni(II) complexes underwent rapid gelation leading to highly enta…

Tradisjonalisme og faktaorientering blant historielærere? Utvelgelsesprosesser for læreverk i historie i videregående skole: en pilotundersøkelse

2012

Denne artikkelen rapporterer fra en pilotstudie av utvelgelsesprosesser og kriterier som benyttes i valg av læreverk i historie i videregående skole. Problemstillingene som belyses er følgende: Hvilke prosesser settes i gang når nye læreverk skal velges i de 18 videregående skolene på Agder? Hvilke kriterier benyttes for dette valget? Hvorfor ble det foretrukne læreverket valgt? Materialet som er brukt i artikkelen er tilbakemeldinger fra de 18 videregående skolene på Agder som har historie som studieforberedende fag. En sammenligning med landet for øvrig gjøres med utgangspunkt i Cappelen Damms oversikt over de ulike historieverks markedsandeler. På landsplan er det eldste verket fra Cappe…

Engelska lånord i datortidningarna PC För Alla och MikroBitti

2009

Formulation of Different Chitosan Hydrogels for Cartilage Tissue Repair

2014

Different formulations of Chitosan/sulphate and Chitosan/PEGDE were produced by physical and chemical reticulation to obtain hydrogels with better physiochemical properties. The hydrogels were analyzed – in terms of their non-toxicity, proliferative, differentiative, inflammatory and immunology responses. Commercial grade Chitosan (Sigma) was solubilized and purified by progressive filtrations. Then, the polymer was freeze-dried in a water soluble cationic form. A physical hydrogel was prepared by mixing a 3 % w/w water solution of the a.m. polymer with different stoichiometric ratios of (SO4=) 1/0.5;1/0.75;1/1 respectively. The hydrogels were cross-linked in multiwells. The chemical hydrog…

Notes sobre la tradició textual del Llibre dels Àngels de Francesc Eiximenis

2010

L’edició completa de les obres de Francesc Eiximenis és una empresa filològica que presenta dificultats objectives, no només perquè les obres tenen un pes material més que considerable, sinó també per la gran quantitat de testimonis manuscrits i impresos que cal col·lacionar. Amb l’objectiu d’ajudar a superar aquestes dificultats, ja fa alguns anys que l’Institut de Llengua i Cultura Catalanes de la Universitat de Girona ha emprès la publicació de les Obres de Francesc Eiximenis, i avui afortunadament podem afirmar que les obres d’Eiximenis, especialment les inèdites, ja tenen equips de treball que s’ocupen de la preparació de les edicions corresponents. Paral·lelament, i en la mateixa líni…