Search results for "GENES"
showing 10 items of 13944 documents
Cómo crear una actividad H5P de secuencia de imágenes en el Aula Virtual
2022
En este videotutorial se muestra cómo crear una actividad H5P de secuencia de imágenes (image sequencing) en el Aula Virtual (Moodle 3.11). Este trabajo forma parte del Proyecto de Innovación Docente Multimedia learning objects in moodle: Sustainable Development Goals (Ref: UV-SFPIE_PID-1640789) financiado por el Vicerrectorado de Ocupación y Programas Formativos de la Universitat de València en el curso académico 2021/2022.
Stress sensitivity of stylolite morphology
2009
International audience; Stylolites are rough surfaces that form by localized stress-induced dissolution. Using a set of limestone rock samples collected at different depths from a vertical section in Cirque de Navacelles (France), we study the influence of the lithostatic stress on the stylolites morphology on the basis of a recent morphogenesis model. We measured the roughness of a series of bedding-parallel stylolites and show that their morphology exhibits a scaling invariance with two self-affine scaling regimes separated by a crossover-length (L) at the millimeter scale consistent with previous studies. The importance of the present contribution is to estimate the stylolite formation s…
The Spanish Version of the State Self-Compassion Scale–Long Form (SSCS–L): A Study of Its Validity and Reliability in a Sample of Nursing Students
2022
Background: In nurses, self-compassion mitigates the effects of stress, burnout and compassion fatigue, and enhances empathy, compassion and well-being and quality of life. The Self-Compassion Scale is the most-used instrument. The aim of this study is to validate the Spanish version of the new developed State Self-Compassion Scale–Long (SSCS–L). Methods: Students of the first year of the Nursing Degree were surveyed online. Together with the SSCS–L, their levels of positive and negative affect was reported. Analyses included descriptive statistics, competitive confirmatory factor analysis, evidence on criterion-related validity and estimates of reliability. Results: The b…
The Time-Varying Effect of Participatory Shift Scheduling on Working Hour Characteristics and Sickness Absence: Evidence from a Quasi-Experiment in H…
2022
Participatory shift scheduling for irregular working hours can influence shift schedules and sickness absence. We investigated the effects of using participatory shift scheduling and shift schedule evaluation tools on working hour characteristics and sickness absence. We utilized a panel data for 2015−2019 with 16,557 hospital employees (6143 in the intervention and 10,345 in the control group). Difference-in-differences regression with ward-level clustered standard errors was used to estimate the average treatment effect on the treated coefficients relative to timing of the intervention with 95% confidence intervals (CI). Using participatory scheduling tool increased long working hou…
Bcl-xL as a Modulator of Senescence and Aging
2021
Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. However, constant stresses and a weakening immune system can lead to senescence chronicity with aging. The accumulation of senescent cells is directly related to tissue dysfunction and age-related pathologies. Centenarians, the most aged individuals, should accumulate senescent cells and suffer from their deleterious effects,…
Consensus nomenclature for CD8(+) T cell phenotypes in cancer
2015
International audience; Whereas preclinical investigations and clinical studies have established that CD8+ T cells can profoundly affect cancer progression, the underlying mechanisms are still elusive. Challenging the prevalent view that the beneficial effect of CD8+ T cells in cancer is solely attributable to their cytotoxic activity, several reports have indicated that the ability of CD8+ T cells to promote tumor regression is dependent on their cytokine secretion profile and their ability to self-renew. Evidence has also shown that the tumor microenvironment can disarm CD8+ T cell immunity, leading to the emergence of dysfunctional CD8+ T cells. The existence of different types of CD8+ T…
Variazioni di carbonio organico nei suoli italiani dal 1979 al 2008
2010
I suoli contengono circa tre volte la quantità di carbonio disponibile a livello mondiale nella vegetazione e circa il doppio di quella presente in atmosfera. Tuttavia il carbonio organico del suolo (SOC) si è ridotto in molte aree, mentre è stato rilevato un aumento della CO2 atmosferica. Ricerche recenti hanno dimostrato che sono stati i cambiamenti di uso e gestione del suolo a provocare le maggiori perdite di SOC nel recente passato, piuttosto che le più alte temperature e i cambiamenti delle precipitazioni conseguenti il cambiamento climatico. Lo scopo principale di questo lavoro è quello di stimare le variazioni del contenuto di carbonio organico dei suoli (carbon stock, CS) in Italia…
Identification of a new nonsense mutation (Tyr129Stop) of the SRY gene in a newborn infant with XY sex-reversal.
2004
Point mutations and deletions of SRY gene have been described in several cases of XY gonadal dysgenesis. To date, most of these mutations affect the HMG domain of SRY which plays a central role in DNA binding activity of SRY. We report on a non-mosaic XY sex-reversed newborn girl (completely female external genitalia). The direct sequencing of SRY showed a new nonsense mutation in a codon of SRY gene flanking the 3' end of the HMG domain: a thymine is replaced by a guanine at position +387 in codon 129, resulting in the replacement of the amino acid tyrosine (TAT) by a stop codon (TAG). The new mutation of this patient provides further evidence to support the functional importance of the pu…
The Impact of Adolescent Internet Addiction on Sexual Online Victimization: The Mediating Effects of Sexting and Body Self-Esteem
2021
Adolescents’ problematic use of the internet and the risk of sexual online victimization are an increasing concern among families, researchers, professionals and society. This study aimed to analyze the interplay between adolescents’ addiction to social networks and internet, body self-esteem and sexual–erotic risk behavior online: sexting, sextortion and grooming. While sexting refers to the voluntary engagement in texting sexual–erotic messages, sextortion and grooming are means of sexual–erotic victimization through the use of the internet. Participants were 1763 adolescents (51% girls), aged 12 to 16 years (M = 14.56
Development and validation of the Adolescent Sexting Scale (A-SextS) with a Spanish sample
2020
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