Search results for "GENETIC STRUCTURE"
showing 10 items of 2283 documents
Cardiovascular outcomes after cardiac resynchronization therapy in cardiac amyloidosis
2021
Abstract Aims Cardiac resynchronization therapy (CRT) is highly effective in dilated cardiomyopathy (DCM) patients with impaired left ventricular ejection fraction (LVEF) and left bundle block branch. In cardiac amyloidosis (CA) patients, left ventricular dysfunction and conduction defects are common, but the potential of CRT to improve cardiac remodelling and survival in this particular setting remains undefined. We investigated cardiovascular outcomes in CA patients after CRT implantation in terms of CRT echocardiographic response and major cardiovascular events (MACEs). Methods and results Our retrospective study included 47 CA patients implanted with CRT devices from January 2012 to Feb…
Visual Performance after AcrySof ReSTOR Aspheric Intraocular Lens Implantation
2008
Purpose: To evaluate distance, intermediate and near visual performance in patients who had undergone implantation of the multifocal aspheric AcrySof ReSTOR intraocular lens (IOL). Methods: Binocular best distance corrected visual acuity (BCVA) at high and low contrast [4 m], best distance corrected near visual acuity (BCNVA) [40 cm], intermediate visual acuity [80 and 60 cm], and distance contrast sensitivity (CS) under photopic [85 cd/m2] and mesopic [3 cd/m2] conditions, were measured in 36 eyes that underwent implantation of the AcrySof ReSTOR Aspheric IOL (SN6AD3). Results: At the 3-month postoperative visit, binocular BCVA was -0.058±0.091, 0.200±0.079, and 0.258±0.071 logMAR, for 100…
Retina Summit Karlsruhe 2009
2009
During the this year´s Retina Summit Karlsruhe, an international expert faculty of 20 highly renowned retina specialists and more than 300 participants found their way to Karlsruhe to share their knowledge of the latest trends in surgical technology and pharmacology. After an angiography course on Friday, the 1-day symposium of almost 40 short lectures covered recent developments in age-related macular degeneration and diabetic macular edema, and the implications and challenges associated with microincision vitrectomy surgery, new devices and advances in imaging technologies.
Analysis of the Peripapillary and Macular Regions Using OCT Angiography in Patients with Schizophrenia and Bipolar Disorder
2021
Purpose: To measure RNFL and vasculature around the optic disc and in the macula in patients with schizophrenia (SZ) and bipolar disorder (BD) using optical coherence tomography angiography (OCTA). Methods: 24 eyes of patients with SZ and 16 eyes of patients with BD as well as 30 eyes of healthy subjects were examined with OCTA. The radiant peripapillary capillary (RPC) density and RNFL thickness were measured in the peripapillary area. Moreover, macular thickness and vessel density were measured in both superficial and deep layers. Results: Significantly decreased values of vessel density in the macular deep vascular complex were found in the eyes of patients with SZ, compared to BD and th…
Binocular Vision in Patients with Multiple Sclerosis.
2021
Amparo Gil-Casas,1,2 David P Piñero-Llorens,2 Ainhoa Molina-Martin2 1Clínica Optométrica, Fundació Lluís Alcanyís, University of Valencia, Valencia, Spain; 2Optics and Visual Perception Group (GOPV), Department of Optics, Pharmacology, and Anatomy, University of Alicante, Alicante, SpainCorrespondence: Ainhoa Molina-MartinDepartment of Optics, Pharmacology, and Anatomy, University of Alicante, Carretera San Vicente del Raspeig, San Vicente del Raspeig, 03690, Alicante, SpainTel +34 965 903-400Email ainhoa.molina@ua.esPurpose: Oculomotor disorders have been reported in multiple sclerosis (MS) in up to 80% of cases. There have …
A Real-World Study of Dexamethasone Implant in Treatment-Naïve Patients with Diabetic Macular Edema: Efficacy and Correlation Between Inflammatory Bi…
2020
Purpose There has been an increasing clinical interest in specific retinal parameters as non-invasive biomarkers of retinal inflammation in diabetic macular edema (DME) that have been shown to have prognostic value, such as hyperreflective retinal fields (HRFs) and subfoveal neuroretinal detachment (SND). Methods We conducted a prospective, non-comparative study of treatment-naive patients with DME to evaluate the efficacy of a Pro Re Nata (PRN) regimen of intravitreal dexamethasone implant 0.7 mg (DexI, Ozurdex™). After administration, patients underwent subsequent injections according to PRN criteria in case of edema relapse, but not earlier than 4 months after the previous treatment. Pat…
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
2015
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic nerve. The retina is formed by the association of the neurosensory retina and the retinal pigment epithelium that is supported by Bruch’s membrane. Both the physical and metabolic associations between these partners are crucial for the functioning of the retina, by means of nutrient intake and removal of the cell and metabolic debris from the retina. Dysequilibrium are involved in the aging processes and pathologies such as age-related macular degeneration, the leading cause of visual loss after the age of 50 years inWestern countries. The retina is composed of severa…
The Effects of Melodic Grouping and Meter on Eye Movements during Simple Sight-Reading Tasks
2009
This study concerns the processes of eye movements during simple sight-reading tasks, concentrating on the processing of melodic groups separated by larger intervals and the effects of metrical placement of such groups. Thirty-two participants with varying musical background sight-read eight short melodies in two separate sessions. Eye movements during playing were recorded using an eye-tracker, and the performances on an electric piano with sequencer software. The melodies in question were of two types: melodic groupings were either aligned with the metrical divisions or made to overlap with them. The results indicate that reinspections to previously fixated notes during sight-reading incr…
First combined flux chamber survey of mercury and CO2 emissions from soil diffuse degassing at Solfatara of Pozzuoli crater, Campi Flegrei (Italy): M…
2014
Abstract There have been limited studies to date targeting gaseous elemental mercury (GEM) flux from soil emission in enriched volcanic substrates and its relation with CO 2 release and tectonic structures. In order to evaluate and understand the processes of soil–air exchanges involved at Solfatara of Pozzuoli volcano, the most active zone of Campi Flegrei caldera (Italy), an intensive field measurement survey has been achieved in September 2013 by using high-time resolution techniques. Soil–air exchange fluxes of GEM and CO 2 have been measured simultaneously at 116 points, widely distributed within the crater. Quantification of gas flux has been assessed by using field accumulation chamb…
No phylogeographic structure in the circumpolar snowy owl (Bubo scandiacus)
2008
The snowy owl (Bubo scandiacus) is a nomadic species with a circumpolar distribution. It has recently declined in the western Palearctic and may thus be worthy of special consideration for conservation. We investigated genetic structure in three well separated geographic regions within the snowy owls’ breeding range. We sequenced two mitochondrial genes; the control region and cytochrome b, and two Z-chromosome introns; VLDLR-9 and BRM-15. We found no phylogeographic structure among the sampled regions, indicating high levels of gene flow in the recent past and possibly still today. Intra-population diversity did not vary between regions for the control region, but for Cyt b, North American…