Search results for "GENETICA"
showing 10 items of 906 documents
Il PTHrP [38-94]-amide è un fattore “DNA-binding”: dati citogenetica e molecolari ed effetto biologico su cellule epiteliali mammarie immortalizzate …
2004
Nuclear myc promoter-binding protein-1 (MBP-1) expression is a prognostic factor in invasive ductal breast carcinoma
2010
Insulators are DNA elements that block the extension of a condensed chromatin domain into a transcriptionally active region or prevent the interaction of a distal enhancer with a promoter when placed between the two. Human c-Myc and Pvt-1 genes map close each other and are separated by an intergenic region rich of DNAseI hypersensitivity sites. Starting from the observation that PVT1 expression is restricted to a low number of normal tissues compared to the wide distribution of c-Myc mRNA we focus our studies on the function and structure of the regions surrounding the DHs present between the two genes. Stable and transient transfection, indicate that one of the regions (HB-2.8) has enhance…
Decorin transfection in breast cancer cells induces proteomic modulation and downregulation of matrix proteases.
2005
Caratterizzazione funzionale e strutturale di un isolatore cromatinico localizzato tra i geni c-Myc e Pvt-1 umani
2008
DNA DEMETHYLATION CAUSED BY 5-AZA-2’-DEOXYCYTIDINE TREATMENT AFFECTS GENOME STABILITY BY INDUCING MITOTIC ALTERATIONS AND ANEUPLOIDY IN HCT-116 TUMOR…
2014
Anti-oncogenic role of decorin: identification of new markers.
2009
Trent’anni di attività della sezione ANISN di Palermo: curricolo verticale e innovazione didattica, dal macroscopico al microscopico
2018
E qui riportata la storia dell’ANISN, Associazione nata nel 1979 e che si fonda sul volontariato di docenti, scienziati, cultori della materia, per migliorare la professionalità docente e la qualità dell’istruzione scientifica in Italia. Oltre a ricordare che l’ANISN è nell'elenco degli enti qualificati per la formazione dei docenti presso il sito del MIUR: http://archivio.pubblica.istruzione.it/dg_pe rs_scolastico/enti_accreditati.shtml, si presenteranno: a) le attività dell’ANISN, gli atti dei Convegni nazionali, i periodici quadrimestrali, il foglio di news inviato alla mailing list dei soci e quanto offerto dal sito: http://www.anisn.it/nuovosito, dove comunque è riservata un’area ai so…
Thanatos associated protein 11 (THAP11) modulates expression of c-MYC by binding the HB2.8 enhancer blocker element.
2014
An In Vitro Model of Glioma Development
2023
Gliomas are the prevalent forms of brain cancer and derive from glial cells. Among them, astrocytomas are the most frequent. Astrocytes are fundamental for most brain functions, as they contribute to neuronal metabolism and neurotransmission. When they acquire cancer properties, their functions are altered, and, in addition, they start invading the brain parenchyma. Thus, a better knowledge of transformed astrocyte molecular properties is essential. With this aim, we previously developed rat astrocyte clones with increasing cancer properties. In this study, we used proteomic analysis to compare the most transformed clone (A-FC6) with normal primary astrocytes. We found that 154 proteins are…
A Glimpse into Chromatin Organization and Nuclear Lamina Contribution in Neuronal Differentiation
2023
During embryonic development stem cells undergo the differentiation process so that they can specialise for different functions within the organism. Complex programs of gene transcription are crucial for this process to happen. Epigenetic modifications and the architecture of chromatin in the nucleus, by the formation of specific regions of active as well as inactive chromatin, allow the coordinated regulation of the genes for each cell fate. In this mini review, we discuss the current knowledge regarding the regulation of three-dimensional chromatin structure during neuronal differentiation. We also focus on the role played in neurogenesis by the nuclear lamina that ensures the tethering o…