Search results for "GENETICA"

CARATTERIZZAZIONE MORFOLOGICA E GENETICA DI POPOLAZIONI DI CAPPARIS SPINOSA L. IN SICILIA.

2011

Genotyping of sicilian Ophrys (Orchidaceae) from Parco delle Madonie

2008

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

2013

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…

Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Itali…

2022

Constitutional BRCA1/BRCA2 pathogenic or likely pathogenic variants (PVs) are associated with an increased risk for developing breast and ovarian cancers. Current evidence indicates that BRCA1/2 PVs are also associated with pancreatic cancer, and that BRCA2 PVs are associated with prostate cancer risk. The identification of carriers of constitutional PVs in the BRCA1/2 genes allows the implementation of individual and family prevention pathways, through validated screening programs and risk-reducing strategies. According to the relevant and increasing therapeutic predictive implications, the inclusion of BRCA testing in the routine management of patients with breast, ovarian, pancreatic and…

The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-S…

2022

The development of innovative technologies and the advances in the genetics and genomics, have offered new opportunities for personalized treatment in oncology. Although the selection of the patient based on the molecular characteristics of the neoplasm has the potential to revolutionize the therapeutic scenario of oncology, this approach is extremely challenging. The access, homogeneity, and economic sustainability of the required genomic tests should be warranted in the clinical practice, as well as the specific scientific and clinical expertise for the choice of medical therapies. All these elements make essential the collaboration of different specialists within the Molecular Tumor Boar…

MORPHOLOGICAL AND GENETIC CHARACTERIZATION OF A LARGE COLLECTION OF ITALIAN TOMATO LANDRACES

2016

Increased interest towards traditional tomato varieties is fuelled by the need to rescue desirable organoleptic traits and to improve the quality of fresh and processed tomatoes in the market. In addition, the phenotypic and genetic variation preserved in tomato landraces represents a means to understand the genetic basis of traits related to health and organoleptic aspects and to breed them in modern varieties. In the frame of Horizon 2020, the TRADITOM project "Traditional tomato varieties and cultural practices: a case for agricultural diversification with impact on food security and health of European population" (http://traditom.eu/) aims to the collection, characterization and valoris…

The effects of structural changes on the anti-microbial and anti-proliferative activities of diimidazolium salts

2017

An array of diimidazolium salts has been synthesized and used to investigate their anti-microbial and anti-proliferative activities. In particular, salts based on the 3,30-di-n-alkyl-1,10-(1,n-phenylenedimethylene)- diimidazolium cation and differing in the alkyl chain length on the imidazolium ion, the isomeric substitution on the aromatic spacer and in the anion nature were used. The anti-proliferative activity was evaluated against cervical (HeLa), colon adenocarcinoma (HT-29) and breast (SKBR3) cancer cell lines. In the latter case, also a morphological assessment after treatment with salts was performed. All salts were tested for their hemolytic activity against human erythrocytes. On …

Botanica: fondamenti di biologia delle piante

2014

Questa nuova edizione del “Mauseth”, la terza italiana, propone un testo riunificato in un volume unico sulla base di precise esigenze di molti corsi. Non si tratta semplicemente della traduzione della quarta Edizione americana ma di una revisione critica più aderente ai corsi delle Università italiane. Si è tentato di rendere più conciso il testo, pur aggiornandolo con nuove conoscenze, ma mantenendo e talora ampliando l’iconografia originale. Inoltre, taluni capitoli sono stati arricchiti con inserti originali e schemi nuovi che i Colleghi estensori di taluni argomenti, specialmente della parte di Botanica generale, ci hanno aiutato ad ideare. Anche la parte di Botanica sistematica ed eco…

Genetic Variability and Taxonomical Considerations about Six Species of European Cardueline Finches (Aves, Passeriformes)

1997

Abstract Electrophoretic patterns of seven enzyme systems and two nonenzymatic proteins, albumin and haemoglobin, representing 13 loci, have been investigated in six species of cardueline finches with Palearctic distribution. A new locus, SOD-3, has been characterized in this subfamily. The two nonenzymatic proteins turned out to be the best genetic markers. From the analysis of the genetic distances it emerges that the mean values between species are higher than those reported for other groups of birds. However, the same results were obtained for other species of the same subfamily native to North America. In both cases this result is probably due to a classification that disagrees with th…

Triebsphäre und Urkindheit des Ich

2009

This paper explores Husserl’s late manuscripts in order to sketch a phenomenological description of drives and the dimension of passive constitution that belongs to them. Although this topic touches upon psychological issues, it will be shown that a specifically phenomenological approach allows us to recognize the transcendental significance of instincts. By means of the phenomenological reduction, drives reveal a peculiar subject, the ‘original child’, which is described not as a figure of developmental psychology but as a transcendental subject pre-forming the way the world appears to us. Drives work constantly and passively as obscure sources of sense, and the original child is always in…