Search results for "GERONTOLOGY"

Voluntary Imitation in Alzheimer’s Disease Patients

2016

International audience; Although Alzheimer's disease (AD) primarily manifests as cognitive deficits, the implicit sensorimotor processes that underlie social interactions, such as automatic imitation, seem to be preserved in mild and moderate stages of the disease, as is the ability to communicate with other persons. Nevertheless, when AD patients face more challenging tasks, which do not rely on automatic processes but on explicit voluntary mechanisms and require the patient to pay attention to external events, the cognitive deficits resulting from the disease might negatively affect patients' behavior. The aim of the present study was to investigate whether voluntary motor imitation, i.e.…

SART and Individual Trial Mistake Thresholds: Predictive Model for Mobility Decline

2021

The Sustained Attention to Response Task (SART) has been used to measure neurocognitive functions in older adults. However, simplified average features of this complex dataset may result in loss of primary information and fail to express associations between test performance and clinically meaningful outcomes. Here, we describe a new method to visualise individual trial (raw) information obtained from the SART test, vis-à-vis age, and groups based on mobility status in a large population-based study of ageing in Ireland. A thresholding method, based on the individual trial number of mistakes, was employed to better visualise poorer SART performances, and was statistically validated with bin…

Participant characteristics associated with the effects of a physical and cognitive training program on executive functions

2022

Background: Physical and cognitive interventions have been shown to induce positive effects on older adults’ executive functioning. However, since participants with different background characteristics may respond differently to such interventions, we investigated whether training effects on executive functions were associated with sex, training compliance, and age. We also investigated if change in global cognition was associated with physical and cognitive training intervention-induced changes in executive functions. Methods: Exploratory data from a randomized controlled trial were analyzed. Participants were 70–85-year-old men and women who received a 12-month physical (PT) or physical a…

Physical activity and exercise in mild cognitive impairment and dementia::an umbrella review of intervention and observational studies

2020

Objectives:\ud \ud The aim of this umbrella review was to determine the effect of physical activity/exercise on improving cognitive and noncognitive outcomes in people with MCI (mild cognitive impairment) and dementia.\ud \ud Design:\ud \ud Umbrella review of systematic reviews (SR), with or without meta-analyses (MAs), of randomized controlled trials (RCTs) and observational studies.\ud \ud Settings and Participants:\ud \ud People with MCI or dementia, confirmed through validated assessment measures. Any form of physical activity/exercise was included. As controls, we included participants not following any prespecified physical activity/exercise intervention or following the same standard…

Onnistunutta vanhenemista etsimässä: IAGG-ER2019, Göteborg

2019

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.

2013

Hutchinson-Gilford progeria syndrome (HGPS) is a rare human genetic disease that leads to a severe premature ageing phenotype, caused by mutations in the <i>LMNA</i> gene. The <i>LMNA</i> gene codes for lamin-A and lamin-C proteins, which are structural components of the nuclear lamina. HGPS is usually caused by a de novo <i>C1824T</i> mutation that leads to the accumulation of a dominant negative form of lamin-A called progerin. Progerin also accumulates physiologically in normal ageing cells as a rare splicing form of lamin-A transcripts. From this perspective, HGPS cells seem to be good candidates for the study of the physiological mechanisms of ageing…

Patients’ preferences for osteoarthritis treatment: the value of stated-preference studies

2019

Context of validation of non-formal and informal learning in Spain: a comprehensive view

2019

The system of validation and accreditation of professional qualifications in Spain is offered as a certification opportunity, especially for vulnerable groups. The procedure is presented as an evaluative proposal that allows some inequalities associated with training and employment to be addressed. In this article we analyse whether this system really fosters social cohesion, considering the political situation that frames the procedure and the educational approach underlying it. The research methodology combines the documentary analysis and interviews with the application of the Delphi method. The most relevant results show that the socio-political context is favourable to competences accr…

The Mediating Role of C-Reactive Protein and Handgrip Strength Between Obesity and Walking Limitation

2008

OBJECTIVES: To study the association between different obesity indicators and walking limitation and to examine the role of C-reactive protein (CRP) and handgrip strength in that association. DESIGN: A cross-sectional, population-based study. SETTING: The Health 2000 Survey with a representative sample of the Finnish population. PARTICIPANTS: Subjects aged 55 and older with complete data on body composition, CRP, handgrip strength, and walking limitation (N=2,208). MEASUREMENTS: Body composition, anthropometrics, CRP, medical conditions, handgrip strength, and maximal walking speed were measured in the health examination. Walking limitation was defined as maximal walking speed less than 1.2…

Wprowadzenie do edukacji osób starszych. W kręgu pedagogiki katolickiej

2020

Education of the elderly has a chance to become a phenomenon of the 21st century. Polish society, like other European and developed countries, is aging faster (GUS forecasts that in 2050 old people will constitute about 40% of the population in Poland). The level of education of the older population also increases proportionally. In the years 2002–2011, an increase in the level of education of the Polish population was recorded, and this also applied to people aged at least 60. There were significant changes in the structure of education of the elderly. The most visible is the increase in the percentage of people with higher education which for this age group amounted to 9,5% in 2011 agains…