Search results for "GHD"

Metabolic impact of adult-onset, isolated, growth hormone deficiency (AOiGHD) due to destruction of pituitary somatotropes.

2011

Growth hormone (GH) inhibits fat accumulation and promotes protein accretion, therefore the fall in GH observed with weight gain and normal aging may contribute to metabolic dysfunction. To directly test this hypothesis a novel mouse model of adult onset-isolated GH deficiency (AOiGHD) was generated by cross breeding rat GH promoter-driven Cre recombinase mice (Cre) with inducible diphtheria toxin receptor mice (iDTR) and treating adult Cre(+/-), iDTR(+/-) offspring with DT to selectively destroy the somatotrope population of the anterior pituitary gland, leading to a reduction in circulating GH and IGF-I levels. DT-treated Cre(-/-), iDTR(+/-) mice were used as GH-intact controls. AOiGHD im…

A bending theory of thermoelastic diffusion plates based on Green-Naghdi theory

2017

Abstract This article is concerned with bending plate theory for thermoelastic diffusion materials under Green-Naghdi theory. First, we present the basic equations which characterize the bending of thin thermoelastic diffusion plates for type II and III models. The theory allows for the effect of transverse shear deformation without any shear correction factor, and permits the propagation of waves at a finite speed without energy dissipation for type II model and with energy dissipation for type III model. By the semigroup theory of linear operators, we prove the well-posedness of the both models and the asymptotic behavior of the solutions of type III model. For unbounded plate of type III…

Development of in vitro screening of EPS producing LAB for cereal based products.

2009

Valutazione del C-peptide come migliore indice di insulino-secrezione in bambini affetti da deficit di GH

2016

Background: La terapia con GH determina iperinsulinemia sia per effetto diretto del GH sulla β-cellula, sia per effetto controregolatorio indiretto. I dati in letteratura sulla valutazione dell’insulino-secrezione durante terapia con GH, basati prevalentemente su indici surrogati derivati da livelli basali o stimolati di insulinemia, sono piuttosto discordanti tra loro e pochissimi studi hanno considerato i livelli di C-peptide, che sia nei soggetti sani che diabetici rappresentano una stima più accurata della funzione β-cellulare rispetto all’insulinemia. Obiettivi: Valutare l’utilità del C-peptide nello studio dell’insulino-secrezione in bambini GHD durante terapia con GH. Metodi: Abbiamo…

Valutazione dell’insulino-sensibilità tramite clamp euglicemico iperinsulinemico in bambini in terapia sostitutiva con GH.

2018

Background I dati sugli effetti della terapia sostitutiva con ormone somatotropo (GH) sull’insulino-sensibilità sono variabili e talora discordanti tra loro e per gran parte ricavati dall’utilizzo di indici surrogati basali, come Homa-IR, o derivati dall’OGTT, come ISI Matsuda. Scopo Valutare la variazione dell’insulino-sensibilità in un gruppo di pazienti affetti da deficit di GH (GHD) pediatrico confrontando i suddetti indici con il clamp euglicemico iperinsuliemico. Materiali e Metodi In 20 bambini affetti da GHD idiopatico isolato alla diagnosi e dopo 12 mesi di terapia con GH e in 10 controlli con bassa statura costituzionale, oltre ai classici parametri clinico-auxologici (statura, BM…

Commento a "Resistin, visfatin, leptin and omentin are differently related to hormonal and metabolic parameters in growth hormone-deficient children "

2016

Background Nonostante siano ampiamente riconosciuti gli effetti del GH sul tessuto adiposo e il ruolo metabolico delle adipocitochine, i dati in letteratura sono piuttosto discordanti. Obiettivo Scopo di questo studio è stato quello di valutare l’impatto della terapia con GH su una serie di adipocitochine aventi un chiaro ruolo metabolico ma poco studiate in questo contesto clinico. Materiali e metodi In questo studio prospettico sono stati valutati 31 bambini prepuberi (25 M, 6 F; età media di 8.5 ± 1.6 anni) affetti da deficit di GH (GHD) isolato e trattati con GH per almeno 12 mesi consecutivi e 30 controlli sani appaiati per età e sesso. Sia in baseline (in tutti i soggetti) che dopo 12…

Commento a "The impact of real practice inappropriateness and devices' inefficiency to variability in growth hormone consumption"

2015

Questo lavoro di Spandonaro e collaboratori è uno dei pochi lavori scientifici prodotti volti ad analizzare un aspetto poco conosciuto e meritevole di attenzione e opportune riflessioni riguardo alla terapia con ormone somatotropo (GH).

HL7 FHIR with SNOMED-CT to Achieve Semantic and Structural Interoperability in Personal Health Data: A Proof-of-Concept Study

2022

Heterogeneity is a problem in storing and exchanging data in a digital health information system (HIS) following semantic and structural integrity. The existing literature shows different methods to overcome this problem. Fast healthcare interoperable resources (FHIR) as a structural standard may explain other information models, (e.g., personal, physiological, and behavioral data from heterogeneous sources, such as activity sensors, questionnaires, and interviews) with semantic vocabularies, (e.g., Systematized Nomenclature of Medicine—Clinical Terms (SNOMED-CT)) to connect personal health data to an electronic health record (EHR). We design and develop an intuitive health coaching (eCoach…

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications.

2012

We performed an immunogenetic analysis of 345 IGHV-IGHD-IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin. Three immunoglobulin (IG) heavy variable (IGHV) genes accounted for 45.8% of the cases (IGHV1-2, 24.9%; IGHV4-34, 12.8%; IGHV3-23, 8.1%). Particularly for the IGHV1-2 gene, strong biases were evident regarding utilization of different alleles, with 79/86 rearrangements (92%) using allele *04. Among cases more stringently classified as splenic marginal-zone lymphoma (SMZL) thanks to the availability of splenic histopathological specimens, the frequency of IGHV1-2*04 peaked at 31%. The IGHV1-2*04 rearrangements carried significantly lo…

Gender-specific soluble α-klotho levels as marker of GH deficiency in children: a case-control study.

2022

Abstract Purpose To evaluate circulating soluble α-klotho (sαKL) levels in GHD children before and after 12 months of GH treatment (GHT). Methods Auxological and basal metabolic parameters, oral glucose tolerance test for glucose and insulin levels, insulin sensitivity indices and klotho levels were evaluated before and after 12 months of follow-up in 58 GHD children and 56 healthy controls. Results At baseline, GHD children showed significantly lower growth velocity standard deviation score (SDS) (p < 0.001), bone/chronological age ratio (p < 0.001), GH peak and area under the curve (AUC) after arginine test (ARG) (both p < 0.001) and glucagon stimulation test (GST) (p < 0.001 …