Search results for "GIS"
showing 10 items of 7190 documents
Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer Cells
2013
Molecular targeted therapy has shown promise as a treatment for advanced hepatocellular carcinoma (HCC). Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced HCC. However, although sorafenib is well tolerated, concern for its safety has been expressed. Celecoxib (Celebrex®) is a selective cyclooxygenase-2 (COX-2) inhibitor which exhibits antitumor effects in human HCC cells. The present study examined the interaction between celecoxib and sorafenib in two human liver tumor cell lines HepG2 and Huh7. Our data showed that each inhibitor alone reduced cell growth and the combination of celecoxib with sorafenib synergistically inhibited cell growth an…
Risk-Reducing Gynecological Surgery in Lynch Syndrome: Results of an International Survey from the Prospective Lynch Syndrome Database.
2020
Purpose: To survey risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) practice and advice regarding hormone replacement therapy (HRT) in women with Lynch syndrome. Methods: We conducted a survey in 31 contributing centers from the Prospective Lynch Syndrome Database (PLSD), which incorporates 18 countries worldwide. The survey covered local policies for risk-reducing hysterectomy and BSO in Lynch syndrome, the timing when these measures are offered, the involvement of stakeholders and advice regarding HRT. Results: Risk-reducing hysterectomy and BSO are offered to path_MLH1 and path_MSH2 carriers in 20/21 (95%) contributing centers, to path_MSH6 carriers in 19/21 (91%) and…
Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes
2018
The following article: Jung, R.E., Al-Nawas, B., Araujo, M., Avila-Ortiz, G., Barter, S., Brodala, N., ... Windisch, P. (2018). Group 1 ITI Consensus Report: The influence of implant length and design and medications on clinical and patient-reported outcomes. Clinical Oral Implants Research, 29(S16), 69-77, can be accessed at https://doi.org/10.1111/clr.13342. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Objectives: The aim of Working Group 1 was to address the influence of different local (implant length, diameter, and design) and systemic (medications) factors on clinical, radiographic, and patient‐re…
Is COVID‐19 infection more severe in kidney transplant recipients?
2021
International audience; There are no studies which have compared the risk of severe Covid-19 and related mortality between transplant recipients and non-transplant patients. We enrolled two groups of patients hospitalized for Covid-19, i.e., kidney transplant recipients from the French Registry of Solid Organ Transplant (n=306) and a single-center cohort of non-transplant patients (n=795). An analysis was performed among subgroups matched for age and risk factors for severe Covid-19 or mortality. Severe Covid-19 was defined as admission (or transfer) to an intensive care unit, need for mechanical ventilation, or death.Transplant recipients were younger and had more comorbidities compared to…
The Effect of 16-Minute Thermal Stress and 2-Minute Cold Water Immersion on the Physiological Parameters of Young Sedentary Men
2020
This study aimed to determine the effect of 16 minutes of thermal stress followed by 2 minutes of cold water immersion on the physiological parameters of fifty-five sedentary men (mean age 20.15±1.30 years), who were exposed to 16 minutes of sauna (temperature: 90-91℃; relative humidity: 14-16%) followed by 2 minutes of cold water immersion (12℃). The participants' somatic characteristics were determined before entering the sauna, and their body mass and blood pressure were measured before and after sauna treatment. Physiological parameters were monitored during the 16-minute sauna session and the 2-minute cold water immersion (CRIO) or shower. The subjects perspired 0.21-0.27 litres during…
La Justicia Medioambiental y su posible introducción en el Ordenamiento Jurídico Español
2014
La tesis se centra en el concepto de la Justicia Medioambiental, entendida como “el trato justo y la participación significativa de todas las personas, sin consideración de raza, color, origen nacional o posición económica, en el desarrollo, implementación y cumplimiento de las leyes, reglamentaciones y políticas medioambientales”. La tesis analiza el surgimiento del movimiento de la Justicia medioambiental en los Estados Unidos en la década de los ochenta del siglo XX, y realiza un recorrido histórico por las fases de consolidación y de posterior expansión del mismo en suelo europeo. Describe el marco de la justicia medioambiental, entendido como un modelo de análisis de los conflictos med…
Tensiones constitucionales de la intervención del estado colombiano en la exploración y explotación minera respecto de las personas y el territorio
2022
Dentro del marco de la presente investigación, se direcciona estudiar las existentes e históricas tensiones constitucionales entre las entidades territoriales y las facultades propias de su autonomía, así como el poder central materializado a través de la nación, en tal sentido estudiar las figuras conexas, los principios, las regulaciones, la normativa y la jurisprudencia. Lo anterior, a partir de un estudio hermenéutico desde los enfoques del iuspositivismo vs. Iusnaturalismo, los cuales ejercen una función orientadora en las vías y resoluciones jurídicas, frente a las tensiones en cuestión. Por su parte, el modelo de la organización territorial y administrativa del Estado colombiano resp…
I proemi e gli interventi d'autore del «De nugis curialium» di Walter Map
2021
This article analyzes the proems and author's interventions in Walter Map's De nugis curialium, which constitute the author's poetic declarations and therefore allow us to understand the variety and diversity of textual typologies of his only surviving work.
Medisinsk avstandsoppfølging for pasienter med epilepsi : En kvalitativ studie om pasienter med epilepsi sine opplevelser, erfaringer og tanker om ny…
2020
Master's thesis in Health informatics (HSI500) Background There is an increasing focus on the use of medical distance monitoring to improve the quality of patient care and increase the effectiveness of health care. Digital PRO-based solution is a new service for patients with epilepsy. The digital form the patient fills out is used as the basis for outpatient follow-up. Purpose The purpose of this study is to contribute knowledge to whether patients with epilepsy experience benefits of medical distance monitoring. The problem statement in the study was: "What experiences and thoughts do patients with epilepsy have about the utility of medical distance follow-up?" Selection and methodologyTh…
La calidad en la gestión de los Servicios Sociales Municipales: algunas experiencias de INTRESS
2011
Queremos presentar en este breve artículo dos experiencias de INTRESS en el desarrollo de buenas prácticas que puedan ayudar a la implantación de sistemas de gestión de calidad en las administraciones locales así como en organizaciones y entidades del Tercer Sector. Se expone pues, por un lado, la experiencia desarrollada en la Concejalía de Acción Social, Mujer y Familia del Ayuntamiento de Valdemoro (Madrid) a través de la formación de sus profesionales en la gestión por procesos y la mejora continua y por otro lado, la iniciativa 'Indicadores Sociales' desarrollada por la red de Consultoría Social, para el desarrollo de una Web de indicadores sociales que permita compartir resultados y b…