Search results for "GISTs"
showing 10 items of 102 documents
Gastrointestinal stromal tumors (GISTs): Focus on histopathological diagnosis and biomolecular features
2007
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract that are believed to originate from a neoplastic transformation of the intestinal pacemaker cells (interstitial cells of Cajal) normally found in the bowel wall or their precursors. Although the microscopic features have been known for a long time, the defining characteristic of GIST is the presence of the cell-surface antigen CD117 (KIT), which is demonstrated by immunohistochemistry. KIT, which is a growth factor transmembrane receptor, is the product of the proto-oncogene c-kit (chromosome 4). Surgical removal remains the only curative treatment for patients with GISTs. Tumor size, mitotic index,…
Esterase inhibition by synergists in the western flower thrips Frankliniella occidentalis.
2010
BACKGROUND: Western flower thrips (WFT), Frankliniella occidentalis (Pergande), is among the most important crop pests in the south-eastern region of Spain. Its increasing resistance to insecticides constitutes a serious problem, and understanding the mechanisms involved is therefore of great interest. Use of synergists to inhibit the enzymes involved in insecticide detoxification is widely used to determine their responsibility for insecticide resistance. However, they do not always act as intended or expected, and caution must be exercised when interpreting synergist results. RESULTS: Laboratory-selected strains of WFT were used to analyse the effects of the synergists piperonyl butoxide …
The impact of COVID-19 on the practice of Oral and Maxillofacial Pathology in the United States and Canada.
2022
The COVID-19 pandemic has significantly disrupted the delivery of healthcare, including oral healthcare services. The restrictions imposed for mitigating spread of the virus forced dental practitioners to adopt significant changes in their workflow pattern. The aim of this study was to investigate the impact of the pandemic on the practice of oral and maxillofacial pathology in two countries in regard to educational activities, and clinical and diagnostic pathology services.An online questionnaire was distributed to oral and maxillofacial pathologists in the United States and Canada. The survey was designed by combining dichotomous, multiple choice, and Likert response scale questions. Stat…
Attitudes Toward Artificial Intelligence Among Radiologists, IT Specialists, and Industry
2020
Objectives We investigated the attitudes of radiologists, information technology (IT) specialists, and industry representatives on artificial intelligence (AI) and its future impact on radiological work. Materials and Methods During a national meeting for AI, eHealth, and IT infrastructure in 2019, we conducted a survey to obtain participants’ attitudes. A total of 123 participants completed 28 items exploring AI usage in medicine. The Kruskal-Wallis test was used to identify differences between radiologists, IT specialists, and industry representatives. Results The strongest agreement between all respondents occurred with the following: plausibility checks are important to understand the d…
El psicólogo interno residente (PIR) en atención primaria: experiencia en el Complejo Hospitalario Universitario de Albacete
2018
En los últimos tiempos se ha detectado un interés creciente en la inclusión de psicólogos clínicos (PC) en el ámbito de la atención primaria (AP), puesto que una parte significativa de las consultas de este nivel están relacionadas con problemas de salud mental, aumentando la presión asistencial de los médicos y ocasionando un elevado coste económico. La presencia del PC en AP mejoraría la accesibilidad de este servicio, revirtiendo en una mejor calidad asistencial. En varios países se han implementado programas en esta línea, existiendo algunos intentos pioneros en España. Uno de los cambios significativos en este sentido ha sido la inclusión desde el año 2009 de la rotación por AP como ob…
Climate advocacy among Italian pediatric pulmonologists: A national survey on the effects of climate change on respiratory allergies.
2022
Climate change (CC) is expected to negatively impact respiratory health due to air pollution and increased aeroallergen exposure. Children are among the most vulnerable populations due to high ventilation rates, small peripheral airways, and developing respiratory and immunological systems. To assess the current knowledge among Italian pediatric pulmonologists on the potential effects of CC on pediatric respiratory allergic diseases, a national survey was launched online from February 2020 to February 2021. The members of the Italian Pediatric Respiratory Society (SIMRI) were contacted by email and 117 questionnaires were returned (response rate 16.4%). 72.6% of respondents were females, 53…
Tropomyosin: A panallergen that causes a worldwide allergic problem
2021
Background: Panallergens are proteins that take part in key processes of organisms and, therefore, are ubiquitously distributed with highly conserved sequences and structures. One class of these panallergens is composed of the tropomyosins. The highly heat-stable tropomyosins comprise the major allergens in crustaceans and mollusks, which make them important food allergens in exposed populations. Tropomyosins are responsible for a widespread immunoglobulin E cross-reactivity among allergens from different sources. Allergic tropomyosins are expressed in many species, including parasites and insects. Methods: This panallergen class is divided, according to it capacity of induced allergic symp…
COVID-19 pandemic, mechanical reperfusion and 30-day mortality in ST elevation myocardial infarction
2022
ObjectiveThe initial data of the International Study on Acute Coronary Syndromes - ST Elevation Myocardial Infarction COVID-19 showed in Europe a remarkable reduction in primary percutaneous coronary intervention procedures and higher in-hospital mortality during the initial phase of the pandemic as compared with the prepandemic period. The aim of the current study was to provide the final results of the registry, subsequently extended outside Europe with a larger inclusion period (up to June 2020) and longer follow-up (up to 30 days).MethodsThis is a retrospective multicentre registry in 109 high-volume primary percutaneous coronary intervention (PPCI) centres from Europe, Latin America, S…
Clinicians in 25 countries prefer to use lower levels of oxygen to resuscitate preterm infants at birth.
2016
Aim This study determined current international clinical practice and opinions regarding initial fractional inspired oxygen (FiO2) and pulse oximetry (SpO2) targets for delivery room resuscitation of preterm infants of less than 29 weeks of gestation. Methods An online survey was disseminated to neonatal clinicians via established professional clinical networks using a web-based survey programme between March 9 and June 30, 2015. Results Of the 630 responses from 25 countries, 60% were from neonatologists. The majority (77%) would target SpO2 between the 10th to 50th percentiles values for full-term infants. The median starting FiO2 was 0.3, with Japan using the highest (0.4) and the UK usi…