Search results for "GK"

Serological identification of HSP105 as a novel non-Hodgkin lymphoma therapeutic target.

2011

Abstract We reported that the clinical efficacy of dendritic cell–based vaccination is strongly associated with immunologic responses in relapsed B-cell non-Hodgkin lymphoma (B-NHL) patients. We have now investigated whether postvaccination antibodies from responders recognize novel shared NHL-restricted antigens. Immunohistochemistry and flow cytometry showed that they cross-react with allogeneic B-NHLs at significantly higher levels than their matched prevaccination samples or nonresponders' antibodies. Western blot analysis of DOHH-2 lymphoma proteome revealed a sharp band migrating at approximately 100 to 110 kDa only with postvaccine repertoires from responders. Mass spectrometry ident…

Zīmogkrāsas izpēte ar augsti efektīvās šķidrumu hromatogrāfijas metodi

2016

Zīmоgkrāsas izpētе ar augsti еfеktīvās šķidrumu hrоmatоgrāfijas (AЕŠH) mеtоdi. Juhņеviča, K., darba vadītājs Dr.ķīm., asоc. prоf. Mеkšs, P. Maģistra darbs. 64 lappusеs, 12 tabulas, 49 attēli, 40 litеratūras avоti, 1 piеlikums. Latviеšu valоdā. Darbā apkоpоta litеratūra par papīra sastāvu, zīmоgkrāsu sastāvu, zīmоgkrāsu krāsviеlām, zīmоgkrāsu šķīdinātājiеm, krāsviеlu un zīmоgkrāsu analīzеs mеtоdēm, aprakstīti zīmоgkrāsu krāsviеlu dеgradācijas prоdukti, vеikta mеtilēnzilās, mеtilviоlеtās, bāziskās zilās B un mеtilviоlеtās 10B krāsviеlas izpētе ar augsti еfеktīvās šķidruma hrоmatоgrāfijas (AЕŠH) mеtоdi, vеikta krāsviеlas – mеtilviоlеtās 2B izpētе ar masspеktrоmеtrijas mеtоdi. Darbam izvēlētas …

Promoting youth entrepreneurship and employability through non-formal and informal learning: the Latvia case

2019

This paper presents some results of the research on ‘Adult education resources to reduce youth unemployment’, which is a part of the project ‘Implementation of the European agenda for adult learning’. The research applies a mixed-method approach (quantitative and qualitative data analysis). The purpose of the paper is to identify the most/least-efficient non-formal and informal learning methods, forms, and initiatives to promote youth entrepreneurship and employability in Latvia as well as to show the relationship between the profile of young adults and their opinion on these methods, forms, and initiatives. The findings show that the young adults stressed the importance of cooperation with…

The role of informal learning in adults' literacy proficiency

2021

This study used the Programme for International Assessment of Adult Competencies (PIAAC) dataset to examine informal literacy learning’s effects on adults’ literacy proficiency. Also, the factors associated with informal literacy learning at and outside of work were studied. The study participants were Nordic adults aged 35–65 years. The statistical method was regression analysis, and the results indicate that informal literacy activities at work are associated primarily with occupation, and informal literacy activities outside of work with education, parents’ education and gender. Initial education, occupation, language background and age exerted the strongest estimated associations with r…

Dažādu augu lipīdu izmantošana saules aizsargkrēmos

2022

Ar ilgtspējīgu attīstību saistīti risinājumi paliek aktuālāki, tā rezultātā arvien populārāki kļūst dabiski produkti. To pieprasījumu iespējams nodrošināt, lietojot augu lipīdus, pievienojot tos saules aizsargkrēmos, tādejādi aizstājot sintētiskās piedevas. Mērķis bija izpētīt Latvijā bieži sastopamo augu lipīdu sastāvu un salīdzināt, kādas ir to priekšrocības, izmantojot tos saules aizsargkrēmos. Aplūkojot pētījuma rezultātus, redzams ka sūnu un ogu lipīdiem ir potenciālas iespējas aizstāt sintētiskos komponentus saules aizsargkrēmu ražošanā, tajā pašā laikā nesamazinot aizsargkrēma iedarbību un tā SPF vērtību. Veicot GC/MS analīzes, noteiktas lipīdu grupas (aromātiskās karboksilskābes, ta…

Mesenchymal stem cells display hepato-protective activity in lymphoma bearing xenografts.

2012

A disseminated model of non-Hodgkin's lymphoma with prevalent liver metastasis was generated by intraperitoneal (i.p.) injection of EBV(+) B lymphoblastoid SKW6.4 in nude-SCID mice. The survival of SKW6.4 xenografts (median survival = 27 days) was significantly improved when hyaluronan scaffolds embedded with mesenchimal stem cells (MSC) were implanted in the abdominal area 4 days after SKW6.4 injection (median survival = 39.5 days). Mice implanted with MSC showed a significant improvement of hepatic functionality in lymphoma xenografts, as demonstrated by measurement of serum ALT/AST levels. Co-culture of MSC with lymphoma cells enhanced the release of hepatocyte growth factor (HGF) by MSC…

Pirmà wispahrejà Latweeschu lopkopju sapulze Rigâ, 16. un 17. februarî 1909. g.

1909

Hepatitis C virus - associated B cell non-Hodgkin's lymphoma.

2016

The hepatitis C virus (HCV) infected patients are prone to develop bone marrow or various tissue infiltrates with monoclonal B cells, monoclonal B lymphocytosis or different types of B cell non-Hodgkin's lymphoma (BCNHL), of which the most common are splenic marginal zone BCNHL, diffuse large BCNHL and follicular lymphoma. The association between chronic HCV infection and non Hodgkin's lymphoma has been observed especially in areas with high prevalence of this viral infection. Outside the limitations of some studies that have been conducted, there are also geographic, environmental, and genetic factors that contribute to the epidemiological differences. Various microenvironmental signals, s…

HSPH1 inhibition downregulates Bcl-6 and c-Myc and hampers the growth of human aggressive B-cell non-Hodgkin lymphoma

2015

We have shown that human B-cell non-Hodgkin lymphomas (B-NHLs) express heat shock protein (HSP)H1/105 in function of their aggressiveness. Here, we now clarify its role as a functional B-NHL target by testing the hypothesis that it promotes the stabilization of key lymphoma oncoproteins. HSPH1 silencing in 4 models of aggressive B-NHLs was paralleled by Bcl-6 and c-Myc downregulation. In vitro and in vivo analysis of HSPH1-silenced Namalwa cells showed that this effect was associated with a significant growth delay and the loss of tumorigenicity when 10(4) cells were injected into mice. Interestingly, we found that HSPH1 physically interacts with c-Myc and Bcl-6 in both Namalwa cells and pr…

Associations of non-Hodgkin Lymphoma (NHL) risk with autoimmune conditions according to putative NHL loci.

2015

Autoimmune conditions and immune system-related genetic variations are associated with risk of non-Hodgkin lymphoma (NHL). In a pooled analysis of 8,692 NHL cases and 9,260 controls from 14 studies (1988-2007) within the International Lymphoma Epidemiology Consortium, we evaluated the interaction between immune system genetic variants and autoimmune conditions in NHL risk. We evaluated the immunity-related single nucleotide polymorphisms rs1800629 (tumor necrosis factor gene (TNF) G308A), rs1800890 (interleukin-10 gene (IL10) T3575A), rs6457327 (human leukocyte antigen gene (HLA) class I), rs10484561 (HLA class II), and rs2647012 (HLA class II)) and categorized autoimmune conditions as prim…