Search results for "GLP1"
showing 4 items of 4 documents
Incretin-Based Therapies Role in COVID-19 Era: Evolving Insights
2020
The current coronavirus disease 2019 (COVID-19) pandemic has led the scientific community to breach new frontiers in the understanding of human physiology and disease pathogenesis. It has been hypothesized that the human dipeptidyl peptidase 4 (DPP4) enzyme receptor may be a functional target for the spike proteins of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Since DPP4-inhibitors are currently used for the treatment of patients with type-2 diabetes (T2DM), there is currently high interest in the possibility that these agents, or incretin-based therapies (IBTs) in general, may be of benefit against the new coronavirus infection. Diabetes is associated with increased COV…
Liraglutide reduces postprandial hyperlipidaemia by increasing apoB48 catabolism and by reducing apoB48 production
2016
IF 6.080; International audience
Lipoproteins and Cardiovascular Disease: An Update on the Clinical Significance of Atherogenic Small, Dense LDL and New Therapeutical Options
2021
Dyslipidemia is a potent risk factor for the genesis and progression of cardiovascular disease (CVD), and both the concentration and type of low-density lipoproteins (LDL) augment this association. The small, dense LDL (sdLDL) subfraction is the subtype which is most strongly predictive of atherosclerosis and cardiovascular events. In addition to the traditionally available lipid-lowering treatment options, certain novel therapies have been shown to favorably impact sdLDL, among them the antidiabetic class of agents known as glucagon-like peptide 1 receptor agonists (GLP1-RAs). These drugs seem to alter the pathophysiologic mechanisms responsible for the formation and accumulation of athero…
Análisis farmacoeconómico y efectos clínicos de los Agonistas del receptor de GLP1 e Inhibidores de SGLT2 en el tratamiento de la Diabetes Mellitus t…
2022
Introducción y objetivos Los nuevos antidiabéticos análogos de GLP1 e inhibidores de SGLT2 han demostrado una potencia y una seguridad cardiovascular favorable que los está convirtiendo en pilares fundamentales en el tratamiento del paciente con diabetes tipo 2, quedando en la actualidad el inicio de estas terapias en función del criterio clínico o las características del paciente. A su vez, suponen un alto coste económico, sin existir comparación directa clínica o farmacoeconómica. El objetivo de la tesis es valorar la diferencia de coste farmacológico total en relación con la proporción de sujetos que alcanzan el objetivo combinado de HbA1c y peso definido como: HbA1c < 7,0% o un descenso…