Search results for "GMB."

showing 3 items of 3 documents

The chaperone system in glioblastoma multiforme and derived cell lines: diagnostic and mechanistic implications.

2022

BACKGROUND: Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. Novel treatments are needed to counteract the molecular mechanisms of GBM growth and drug resistance. The chaperone system (CS) members are typically cytoprotective but some, termed Hsp, can become pathogenic and participate in carcinogenesis, along with the vascular endothelial growth factor (VEGF), and we investigated them in GBM biopsies and derived cell lines. The objectives were to identify diagnostic-prognostic biomarkers and gather information for developing chaperonotherapy. METHODS: Cell lines from GBMs were established, characterized (morphology, growth characteristics, and sp…

AdultVascular Endothelial Growth Factor AGeneral Immunology and MicrobiologySettore BIO/16 - Anatomia UmanaBrain Neoplasmschaperone system (CS) glioblastoma multiforme (GBM) GMB cell lines heat shock protein (Hsp) vascular endothelial growth factor (VEGF)HSP27 Heat-Shock ProteinsHumansHSP70 Heat-Shock ProteinsGlioblastomaGeneral Biochemistry Genetics and Molecular BiologyCell LineFrontiers in bioscience (Landmark edition)
researchProduct

Oxygen consumption of F0 and F1 larval and juvenile European seabass Dicentrarchus labrax in resonse to ocean acidification and warming

2022

Ongoing climate change is leading to warmer and more acidic oceans. The future distribution of fish within the oceans depends on their capacity to adapt to these new environments. Only few studies have examined the effects of ocean acidification (OA) and warming (OW) on the metabolism of long-lived fish over successive generations. We therefore aimed to investigate the effect of OA on larval and juvenile growth and metabolism on two successive generations of European sea bass (Dicentrarchus labrax L.) as well as the effect of OAW on larval and juvenile growth and metabolism of the second generation. European sea bass is a large economically important fish species with a long generation time…

IdentificationDicentrarchus labrax routine metabolic rate per dry massLife stagedry massType of studyDicentrarchus labrax fork lengthGermanyWeightedCalculatedTreatment temperaturebody lengthlarval growthteleostOcean acidificationdissolvedTreatment partial pressure of carbon dioxideOptical oxygen meter with sensor OXR50 FireStingLaboratory experimentstandard metabolic rate per fresh massTreatment: temperatureDicentrarchus labrax standard metabolic rate per fresh massEarth System Researchmetabolic ratesUniform resource locator link to referenceDicentrarchus labrax dry massStereomicroscopy Leicafork lengthStereomicroscopy (Leica)GenerationOxygen dissolvedTank numberocean warmingjuvenile growthPyroScience GmbHAgeUniform resource locator/link to referenceDATE TIMEDicentrarchus labraxroutine metabolic rate per dry masswet weightedFulton's condition factorSpeciesFish wet weightedCaliperOptical oxygen meter with sensor OXROB10 (FireSting PyroScience GmbH Germany)Optical oxygen meter with sensor OXROB10 FireStingOptical oxygen meter with sensor OXR50 (FireSting PyroScience GmbH Germany)Fulton s condition factorOxygenDATE/TIMEFishSample IDTreatment: partial pressure of carbon dioxideDicentrarchus labrax body lengthmassDicentrarchus labrax mass
researchProduct

Why do Traditional Performance Management Systems in Healthcare not always lead to Improved Performance? Outlining the Unintended Consequences of the…

2021

Researchers all around the globe have not yet come to an end as regards the supposed positive impact of traditional performance management systems in healthcare, and some research has shown that, paradoxically, performance management policies do not always lead to improved hospital performance. Despite the extensive research identifying the “pitfalls” of the NPM reforms around Europe and the unintended consequences for hospital staff and patients, little is known about the mechanisms that caused those negative effects, which essentially creates a research gap worth investigating. This PhD study tries to address this gap and show why do traditional PM Systems in healthcare not always lead to…

Settore SECS-P/07 - Economia AziendalePerformance.Management.Healthcare.Unintended.Counterintuitive.Consequences.Reform.Public.Hospital.Dynamic Performance Management.DPM.Greece.Greek.System Dynamics.Group Model Building.SD.GMB.Causal Loop Diagram.CLD.System.Systemic.
researchProduct