Search results for "GPR"
showing 10 items of 1092 documents
Requirement of cannabinoid CB1 receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections
2010
A role for endocannabinoid signaling in neuronal morphogenesis as the brain develops has recently been suggested. Here we used the developing somatosensory circuit as a model system to examine the role of endocannabinoid signaling in neural circuit formation. We first show that a deficiency in cannabinoid receptor type 1 (CB(1)R), but not G-protein-coupled receptor 55 (GPR55), leads to aberrant fasciculation and pathfinding in both corticothalamic and thalamocortical axons despite normal target recognition. Next, we localized CB(1)R expression to developing corticothalamic projections and found little if any expression in thalamocortical axons, using a newly established reporter mouse expre…
Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study
2003
International audience; The objective of this study was to compare the estrogenicity of xenoestrogens found in food wrap packaging and phytoestrogen flavonoids. Uterotrophic and vaginal cornification assays were performed on immature and ovariectomized rats. Genistein, bisphenol F, and octylphenol were identified as estrogenic only in immature rats. Using vaginal cornification as a more specific estrogenic parameter, all tested compounds except tangeretin were active in immature rats. While apigenin and kaempferol appeared to have low estrogenic activity, they potentialized the uterotrophic effect of 17β-estradiol in immature rats. These data showed that (i) phytoestrogens like genistein ca…
Isoflavonoid-based bone-sparing treatments exert a low activity on reproductive organs and on hepatic metabolism of estradiol in ovariectomized rats
2007
International audience; The use of soy isoflavones is a potential alternative to hormone replacement therapy in post-menopausal bone-loss prevention. Nevertheless, phytoestrogens can target other organs and may disrupt cell proliferation, or could modify endogenous steroid hormone metabolism. These mechanisms could be linked to an increased risk of developing cancer. We therefore studied the possible side effects of such treatments in an experimental model of menopause. Forty adult female Wistar rats were ovariectomized and fed with a genistein-, daidzein- or equol-supplemented diet at bone-sparing levels (10 mg/kg BW/day) for 3 months. The estrogenic effects were assessed by histological a…
GPR investigations at San Nicolò Church: a case-study from the 1669 eruption in the old settlement of Misterbianco (Etna, Sicily)
2023
Misterbianco, located on the southern slope of Mt. Etna (eastern Sicily), was destroyed in the past by two catastrophic events that raised the old town to the ground. The first was the great eruption of 1669, whose lava front buried dozens of villages encountered along its path, entirely destroying the architectural heritage of Etna's southern flank. The second event was the disastrous 1693 Val di Noto earthquake, which caused major destruction throughout south-eastern Sicily, also damaging the few still standing buildings in the town. The GPR survey performed at this site, 350 years after the eruption, allowed a first attempt of planimetric reconstruction of the San Nicolo Church. Starting…
Geophysical investigations at the Himera archaeological site, northern Sicily
2007
In this paper we present a geophysical survey that was carried out as a research activity during field trips to the Himera archaeological site, where relics of a large Greek settlement are still buried, effected by a joint group of archaeologists and geophysicists during an educational project. Two-dimensional (2D) resistivity and ground-penetrating radar (GPR) surveys were performed to locate buried archaeological structures at this archaeological site. The results of the GPR surveys show some anomalies characterized by semi-hyperbolic shapes. In some restricted areas of the town, two grids of parallel GPR profiles were acquired while time- and depth-slices were calculated to identify the …
Finnish and German student teachers’ motivations for choosing teaching as a career. The first application of the FIT-Choice scale in Finland
2019
Abstract This study introduces and validates the Finnish version of the FIT-Choice scale and uses the scale to explore Finnish undergraduate students' motivations for choosing teaching as a career as well as their perceptions of teaching as a profession in comparison to German student teachers. The results replicated the FIT-Choice structure both in Finland and Germany. Sample comparisons revealed that motivations for teaching and perceptions of the teaching profession reflected both differences and similarities between Finland and Germany. The study offers novel information on student teachers’ motivational structure.
Work-loss years among people diagnosed with diabetes: a reappraisal from a life course perspective
2018
Aims Early exit from the workforce has been proposed to be one of the unfavorable consequences of diabetes. We examined whether early exit from the workforce differed between persons who were and were not diagnosed with diabetes during their work career. Methods The cohort included 12,726 individuals of the Helsinki Birth Cohort Study, born between 1934 and 1944. Using data from nationwide registers, the cohort was followed up from early adulthood until they transitioned into retirement or died. Work- loss years were estimated using the restricted mean work years method. Results During a follow-up of 382,328 person-years for men and 349 894 for women, 36.8% transitioned into old age pension…
Workshop on Competencies for the Globalization of Information Systems in Knowledge-Intensive Settings
2010
Software development has become a global task for the past decades. Outsourcing and offshoring solutions have been discussed frequently, in both research and in industry. Export is the main driver for a society’s and corresponding individual’s wealth. As more and more organizations apply outsourcing and offshoring practices, new ways have to be found to compete in this rapidly changing environment. Additionally, the digital divide is becoming a central issue, determining the relation of developed and developing countries.
The yeast Starmerella bacillaris (synonym Candida zemplinina) shows high genetic diversity in winemaking environments.
2015
International audience; The yeast Candida zemplinina (Starmerella bacillaris) is frequently isolated from grape and wine environments. Its enological use in mixed fermentation with Saccharomyces cerevisiae has been extensively investigated these last few years, and several interesting features including low ethanol production, fructophily, glycerol and other metabolites production, have been described. In addition, molecular tools allowing the characterization of yeast populations have been developed, both at the inter- and intraspecific levels. However, most of these fingerprinting methods are not compatible with population genetics or ecological studies. In this work, we developed 10 micr…
3D-QSAR study of ligands for a human olfactory receptor
2005
Abstract Only about 350 olfactory receptors (OR) provide a basis for the remarkable ability of humans to recognise and discriminate a large number of odorants. A recent study reports the odorant repertoire of a human class II OR called OR1G1, including both agonists and antagonists. We used these affinity data to perform a 3D molecular modelling study of these ligands using Catalyst/HypoGen software (Catalyst v4.9.1, Accelrys Inc., San Diego, 2004) to propose alignment models for OR1G1 ligands. We obtained a triple-alignment model, which satisfactorily explained the experimental activities and was able both to predict the antagonist effects of some compounds and to identify new potent agoni…