Search results for "GRAS"
showing 10 items of 727 documents
AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.
2010
The CB1 cannabinoid receptor is the most abundant G-protein coupled receptor in the brain and a key regulator of neuronal excitability. There is strong evidence that CB1 receptor on glutamatergic hippocampal neurons is beneficial to alleviate epileptiform seizures in mouse and man. Therefore, we hypothesized that experimentally increased CB1 gene dosage in principal neurons would have therapeutic effects in kainic acid (KA)-induced hippocampal pathogenesis. Here, we show that virus-mediated conditional overexpression of CB1 receptor in pyramidal and mossy cells of the hippocampus is neuroprotective and moderates convulsions in the acute KA seizure model in mice. We introduce a recombinant a…
Central Modulatory Neurons Control Fuel Selection in Flight Muscle of Migratory Locust
2003
Insect flight is one of the most intense and energy-demanding physiological activities. High carbohydrate oxidation rates are necessary for take-off, but, to spare the limited carbohydrate reserves, long-distance flyers, such as locusts, soon switch to lipid as the main fuel. We demonstrate that before a flight, locust muscles are metabolically poised for take-off by the release of octopamine from central modulatory dorsal unpaired median (DUM) neurons, which increases the levels of the potent glycolytic activator fructose 2,6-bisphosphate in flight muscle. Because DUM neurons innervating the flight muscles are active during rest but selectively inhibited during flight, they stimulate carbo…
The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner.
2021
Neuro-vascular communication is essential to synchronize central nervous system development. Here, we identify angiopoietin/Tie2 as a neuro-vascular signaling axis involved in regulating dendritic morphogenesis of Purkinje cells (PCs). We show that in the developing cerebellum Tie2 expression is not restricted to blood vessels, but it is also present in PCs. Its ligands angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are expressed in neural cells and endothelial cells (ECs), respectively. PC-specific deletion of Tie2 results in reduced dendritic arborization, which is recapitulated in neural-specific Ang1-knockout and Ang2 full-knockout mice. Mechanistically, RNA sequencing reveals that Tie…
Polyunsaturated fatty acids in cultured cardiomyocytes : effect on physiology and beta-adrenoceptor function
1992
This study was carried out to investigate the influence of the membrane fatty acid composition on the basal electrical and contractile activities and the response to beta-adrenergic stimulation of rat cardiac muscle cells in culture. Cells were grown for 3 days in a conventional serum culture medium and then incubated for 24 h in synthetic media containing either n-6 or n-3 as the sole source of polyunsaturated fatty acids (PUFA). The n-6/n-3 ratio in the phospholipids was 0.9 in the n-3 cells and 13.1 in the n-6 cells compared with 6.3 in controls cells. Such modifications did not alter action potentials and the main parameters related to contraction, although shortening was slightly acce…
The Coble Quadric
2023
Given a smooth genus three curve $C$, the moduli space of rank two stable vector bundles on C with trivial determinant embeds in $\mathbb{P}^8$ as a hypersurface whose singular locus is the Kummer threefold of $C$; this hypersurface is the Coble quartic. Gruson, Sam and Weyman realized that this quartic could be constructed from a general skew-symmetric fourform in eight variables. Using the lines contained in the quartic, we prove that a similar construction allows to recover SU$_C(2, L)$, the moduli space of rank two stable vector bundles on C with fixed determinant of odd degree L, as a subvariety of $G(2, 8)$. In fact, each point $p \in C$ defines a natural embedding of SU$_C(2, \mathca…
The Psychology of Thinking in Creating AI
2021
The broad-scale emergence of AI in industry calls forth basic questions in terms of the knowledge bases and approaches relevant for its design. Engineering design has been mainly developed for electromechanical artifacts. In practice, this has meant that the scientific knowledge required for creating technical artifacts such as engines, cars, ships, cranes, telephones, radios, TVs, and simple data processing units has been natural science. However, one cannot find intelligent processes by means of physics and chemistry. Natural scientific phenomena follow their deterministic laws, but intelligence is based on selection and decision processes. The conceptual landscape of natural science is o…
Seeking for the Grasp : An Iterative Subdivision Model of Conceptualisation
2019
Concepts are fundamental collective constructs of individual items that are capable of abstracting meaningfully homogeneous groupings of phenomena. This capability is a prerequisite for communication and action and gives structure to learning and memory. Our study is aligned with the vast paradigm that assumes embodied cognition, rooted in Merleau-Ponty (Phenomenology of perception (trans: C. Smith). Routledge and Kegan Paul, London, 1962), seminally articulated by Varela et al. (Embodied mind: cognitive science and human experience. MIT Press, Cambridge, MA, 1991) and existing today in a number of variants that have been reviewed by Wilson (Six views of embodied cognition. Springer. Psycho…
On the identities of the Grassmann algebras in characteristicp>0
2001
In this note we exhibit bases of the polynomial identities satisfied by the Grassmann algebras over a field of positive characteristic. This allows us to answer the following question of Kemer: Does the infinite dimensional Grassmann algebra with 1, over an infinite fieldK of characteristic 3, satisfy all identities of the algebraM 2(K) of all 2×2 matrices overK? We give a negative answer to this question. Further, we show that certain finite dimensional Grassmann algebras do give a positive answer to Kemer's question. All this allows us to obtain some information about the identities satisfied by the algebraM 2(K) over an infinite fieldK of positive odd characteristic, and to conjecture ba…
Stakeholders’ Attitudes about the Transplantations of the Mediterranean Seagrass Posidonia oceanica as a Habitat Restoration Measure after Anthropoge…
2021
Anthropogenic impacts on Posidonia oceanica meadows have led to a decline of this ecosystem throughout the Mediterranean. Transplantations have often been prescribed as a compensation measure to mitigate the impacts caused by coastal maritime works. Here a Q methodology approach was used to investigate the stakeholders’ attitudes in four case studies of P. oceanica transplants realized in Italian waters. Twenty-two respondents were asked to score 37 statements, and the resultant Q-sorting was analyzed via an inverse PCA using the KADE software. Four discourses, corresponding to the significant axes in the factorial analysis were identified: science and conservation (F1), oriented at a rigor…
Efficient parallel computations of flows of arbitrary fluids for all regimes of Reynolds, Mach and Grashof numbers
2002
This paper presents a unified numerical method able to address a wide class of fluid flow problems of engineering interest. Arbitrary fluids are treated specifying totally arbitrary equations of state, either in analytical form or through look‐up tables. The most general system of the unsteady Navier–Stokes equations is integrated with a coupled implicit preconditioned method. The method can stand infinite CFL number and shows the efficiency of a quasi‐Newton method independent of the multi‐block partitioning on parallel machines. Computed test cases ranging from inviscid hydrodynamics, to natural convection loops of liquid metals, and to supersonic gasdynamics, show a solution efficiency i…