Search results for "GRAS"

The Elovl5 enzyme in breast cancer : regulation of cancer cell proliferation and metastasis

2021

Breast cancer is the most diagnosed cancer and the leading cause of cancer death in women. The 5-year relative survival rate is less than 30% for metastatic breast cancer and metastases account for more than 75% of breast cancer deaths. Fatty acid metabolism is altered in cancer and contributes to tumor progression and metastasis. Here, we were interested in Elongation of very long chain fatty acids protein 5 (Elovl5) which catalyzes the elongation of long-chain fatty acids. We observed that the tumors from patients with a breast cancer had a lower expression of Elovl5 than paired normal breast tissue. However, low expression of Elovl5 is associated with a worse prognosis in breast cancer p…

Distribution of graminoids in open habitats in Tajikistan and Kyrgyzstan

2022

Aims: Landscapes of Middle Asia are exposed to human influence due to long-lasting pastoral tradition, and now are largely dominated by non-forest vegetation. Graminoids perform key ecosystem functions, and constitute an important feed source for livestock. We studied the distribution patterns of graminoids cover under climatic and grazing pressure gradients in different open vegetation types. Study area: Tajikistan, Kyrgyzstan. Methods: 1,525 vegetation plots representing five open vegetation types (mires, salt marshes, tall-forb communities, pseudosteppes and steppes) were extracted from the Vegetation of Middle Asia Database. We assessed the relative cover of graminoid species in each ve…

Bioactive compounds and quality of extra virgin olive oil

2020

Background: Extra virgin olive oil (EVOO) is responsible for a large part of many health benefits associated to Mediterranean diet as it is a fundamental ingredient of this diet. The peculiarities of this golden, highly valued product are in part due to the requirements that must be met to achieve this title, namely, it has to be obtained using exclusively mechanical procedures, its free acidity cannot be greater than 0.8%, it must not show sensory defects, and it has to possess a fruity taste. Methods: All these characteristics are key factors to EVOO quality, thus the chemical composition of these many health-promoting compounds, such as unsaturated fatty acids (which are also the major c…

Mechanical and Thermal Properties of Insulating Sustainable Mortars with Ampelodesmos mauritanicus and Pennisetum setaceum Plants as Aggregates

2021

The use of natural fibers in cement composites is a widening research field as their application can enhance the mechanical and thermal behavior of cement mortars and limit their carbon footprint. In this paper, two different wild grasses, i.e., Ampelodesmos mauritanicus, also called diss, and Pennisetum setaceum, also known as crimson fountaingrass, are used as a source of natural aggregates for cement mortars. The main purpose is to assess the possibility of using the more invasive crimson fountaingrass in place of diss in cement-based vegetable concrete. The two plant fibers have been characterized by means of scanning electron microscopy (SEM), helium picnometry and thermogravimetric an…

The Italian Method of la drammatica: its Legacy and Reception

2014

Multiobjective GRASP with Path Relinking

2015

In this paper we review and propose different adaptations of the GRASP metaheuristic to solve multiobjective combinatorial optimization problems. In particular, we describe several alternatives to specialize the construction and improvement components of GRASP when two or more objectives are considered. GRASP has been successfully coupled with Path Relinking for single-objective optimization. Moreover, we propose different hybridizations of GRASP and Path Relinking for multiobjective optimization. We apply the proposed GRASP with Path Relinking variants to two combinatorial optimization problems, the biobjective orienteering problem and the biobjective path dissimilarity problem. We report …

GyDB mobilomics: LTR retroelements and integrase-related transposons of the pea aphid Acyrthosiphon pisum genome

2011

[EN] The Gypsy Database concerning Mobile Genetic Elements (release 2.0) is a wiki-style project devoted to the phylogenetic classification of LTR retroelements and their viral and host gene relatives characterized from distinct organisms. Furthermore, GyDB 2.0 is concerned with studying mobile elements within genomes. Therefore, an in-progress repository was created for databases with annotations of mobile genetic elements from particular genomes. This repository is called Mobilomics and the first uploaded database contains 549 LTR retroelements and related transposases which have been annotated from the genome of the Pea aphid Acyrthosiphon pisum. Mobilomics is accessible from the GyDB 2.…

Efficient GRASP+VND and GRASP+VNS metaheuristics for the traveling repairman problem

2011

Abstract: The traveling repairman problem is a customer-centric routing problem, in which the total waiting time of the customers is minimized, rather than the total travel time of a vehicle. To date, research on this problem has focused on exact algorithms and approximation methods. This paper presents the first metaheuristic approach for the traveling repairman problem.

Improved heuristics for the regenerator location problem

2014

Telecommunication systems use optical signals to transmit information. The strength of a signal in an optical network deteriorates and loses power as it goes farther from the source, mainly due to attenuation. Therefore, to enable the signal to arrive its intended destination with good quality, it is necessary to regenerate the signal periodically using regenerators. These components are relatively expensive and therefore it is desirable to deploy as few of them as possible in the network. In the regenerator location problem (RLP), we are given an undirected graph, positive edge lengths, and a parameter specifying the maximum length that a signal can travel before its quality deteriorates a…

Algorithms for Pallet Building and Truck Loading in an Interdepot Transportation Problem

2016

This paper deals with the problem of a logistics company that has to serve its customers by first putting the products on pallets and then loading the pallets into trucks. Besides the standard geometric constraints of products not overlapping each other and not exceeding the dimensions of pallets and trucks, in this real problem, there are many other constraints, related to the total weight of the load, the maximum weight supported by each axle, and the distribution of the load inside the truck. Although the problem can be decomposed into two phases, pallet loading and truck loading, we have taken a combined approach, building and placing pallets at the same time. For each position in the t…