Search results for "GSK3-beta"

showing 1 items of 1 documents

Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder

2013

Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-beta (GSK3-beta). The less active GSK3-beta promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-beta gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-beta promoter rs334558 polymorphism on WM microstructure, using DTI and …

AdultMaleCorpus callosumNerve Fibers MyelinatedWhite matterGlycogen Synthase Kinase 3GSK3-β03 medical and health sciences0302 clinical medicineCorona radiataFasciculusmedicineHumansInferior longitudinal fasciculusPromoter Regions GeneticGSK3-β; lithium; bipolar disorder; white matter; cingulum bundle030304 developmental biologybipolar disorderPharmacology0303 health sciencesGlycogen Synthase Kinase 3 betabiologyGenetic VariationMiddle Agedbiology.organism_classification3. Good healthPsychiatry and Mental healthmedicine.anatomical_structurenervous systemlithiumCorticospinal tractSettore BIO/14 - FarmacologiaGSK3-beta lithium bipolar disorder white matter cingulum bundleFemaleOriginal ArticleBrain Gray Mattercingulum bundlePsychologywhite matterNeuroscience030217 neurology & neurosurgeryDiffusion MRI
researchProduct